The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Tumor Necrosis Factor Receptor, subunit A, domain 2
".
FunFam 13: Tumor necrosis factor receptor superfamily member ...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 35 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
8 | E2DGP8 (/IPI) F1R841 (/IPI) P07174 (/IPI) P08138 (/IPI) P08138 (/IPI) P08138 (/IPI) Q5BJ06 (/IPI) Q9Z0W1 (/IPI) |
|
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
4 | P07174 (/ISS) P08138 (/ISS) P08138 (/ISS) P08138 (/ISS) |
|
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
|
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
|
Death receptor activity GO:0005035
Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death.
|
3 | P08138 (/IGI) P08138 (/IGI) P08138 (/IGI) |
|
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
|
3 | P08138 (/IDA) P08138 (/IDA) P08138 (/IDA) |
|
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
|
3 | P08138 (/IDA) P08138 (/IDA) P08138 (/IDA) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
3 | P08138 (/IPI) P08138 (/IPI) P08138 (/IPI) |
|
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
|
Neurotrophin binding GO:0043121
Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
|
3 | P08138 (/ISS) P08138 (/ISS) P08138 (/ISS) |
Showing 1 to 10 of 35 entries
There are 97 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
5 | P07174 (/ISS) P08138 (/ISS) P08138 (/ISS) P08138 (/ISS) P18519 (/ISS) |
|
Cellular glucose homeostasis GO:0001678
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
|
4 | P07174 (/ISS) P08138 (/ISS) P08138 (/ISS) P08138 (/ISS) |
|
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
|
4 | P07174 (/ISS) P08138 (/ISS) P08138 (/ISS) P08138 (/ISS) |
|
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
4 | P07174 (/ISS) P08138 (/ISS) P08138 (/ISS) P08138 (/ISS) |
|
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
|
3 | P08138 (/IMP) P08138 (/IMP) P08138 (/IMP) |
|
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
|
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
|
3 | P08138 (/IDA) P08138 (/IDA) P08138 (/IDA) |
|
Membrane protein intracellular domain proteolysis GO:0031293
The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
Showing 1 to 10 of 97 entries
There are 40 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | P07174 (/IDA) P08138 (/IDA) P08138 (/IDA) P08138 (/IDA) P18519 (/IDA) Q9Z0W1 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P07174 (/TAS) P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) Q9Z0W1 (/TAS) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | P08138 (/TAS) P08138 (/TAS) P08138 (/TAS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
3 | P08138 (/ISS) P08138 (/ISS) P08138 (/ISS) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | P08138 (/NAS) P08138 (/NAS) P08138 (/NAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P07174 (/IDA) Q9Z0W1 (/IDA) |
Showing 1 to 10 of 40 entries
