The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Laminin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 76: Integrin beta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 46 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 A0A0G2JWK0 (/IPI) B3DIP9 (/IPI) O54890 (/IPI) P05106 (/IPI) P05107 (/IPI) P11584 (/IPI) P11584 (/IPI) P11835 (/IPI) P32592 (/IPI) Q3LTM5 (/IPI)
(2 more)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
5 O97702 (/ISS) Q52MQ6 (/ISS) Q92071 (/ISS) Q95JH1 (/ISS) Q9TUN5 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 O97702 (/ISS) Q52MQ6 (/ISS) Q92071 (/ISS) Q95JH1 (/ISS) Q9TUN5 (/ISS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 B2RYB8 (/IPI) P11584 (/IPI) P11584 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 A0A0G2JVU1 (/IPI) D3ZP06 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 O54890 (/IPI) P05106 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 O54890 (/IPI) P05106 (/IPI)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
2 O54890 (/ISO) P11835 (/ISO)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
1 P11835 (/IMP)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
1 P05107 (/ISS)
Showing 1 to 10 of 46 entries

There are 244 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
6 A0A0G2JWK0 (/TAS) P05106 (/TAS) P05107 (/TAS) P26012 (/TAS) Q8R2H2 (/TAS) Q8R2H2 (/TAS)
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
6 P05107 (/ISS) P32592 (/ISS) P53714 (/ISS) Q2VJ42 (/ISS) Q5VI41 (/ISS) Q6ECI6 (/ISS)
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
6 P05107 (/ISS) P32592 (/ISS) P53714 (/ISS) Q2VJ42 (/ISS) Q5VI41 (/ISS) Q6ECI6 (/ISS)
Positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996
Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell.
6 P05107 (/ISS) P32592 (/ISS) P53714 (/ISS) Q2VJ42 (/ISS) Q5VI41 (/ISS) Q6ECI6 (/ISS)
Cell-substrate junction assembly GO:0007044
The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.
5 O97702 (/ISS) Q52MQ6 (/ISS) Q92071 (/ISS) Q95JH1 (/ISS) Q9TUN5 (/ISS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
5 A8DSD5 (/IMP) P05107 (/IMP) P11584 (/IMP) P11584 (/IMP) P53714 (/IMP)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
5 O97702 (/ISS) Q52MQ6 (/ISS) Q92071 (/ISS) Q95JH1 (/ISS) Q9TUN5 (/ISS)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
5 A0A0G2JWK0 (/IMP) B2RYB8 (/IMP) P26012 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Positive regulation of fibroblast migration GO:0010763
Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
4 A0A0G2JWK0 (/IMP) O54890 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Platelet aggregation GO:0070527
The adhesion of one platelet to one or more other platelets via adhesion molecules.
4 A0A0G2JWK0 (/IMP) P05106 (/IMP) Q8R2H2 (/IMP) Q8R2H2 (/IMP)
Showing 1 to 10 of 244 entries

There are 90 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
9 A0A0G2JWK0 (/IDA) B2RYB8 (/IDA) O54890 (/IDA) P05106 (/IDA) P05107 (/IDA) P11835 (/IDA) P26012 (/IDA) Q8R2H2 (/IDA) Q8R2H2 (/IDA)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
8 A0A0G2JWK0 (/IDA) B3DIP9 (/IDA) P05106 (/IDA) P11584 (/IDA) P11584 (/IDA) Q3LTM5 (/IDA) Q8R2H2 (/IDA) Q8R2H2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P05106 (/TAS) P05107 (/TAS) P26012 (/TAS) Q8R2H2 (/TAS) Q8R2H2 (/TAS)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
5 O97702 (/ISS) Q52MQ6 (/ISS) Q92071 (/ISS) Q95JH1 (/ISS) Q9TUN5 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 P32592 (/ISS) P53714 (/ISS) Q2VJ42 (/ISS) Q5VI41 (/ISS) Q6ECI6 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 B2RYB8 (/IDA) P05106 (/IDA) P11584 (/IDA) P11584 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
4 O54890 (/IDA) P05106 (/IDA) P11584 (/IDA) P11584 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 A0A0G2JWK0 (/IDA) P11835 (/IDA) Q8R2H2 (/IDA) Q8R2H2 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
4 A0A0G2JWK0 (/IDA) O54890 (/IDA) Q8R2H2 (/IDA) Q8R2H2 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
3 P11584 (/ISS) P11584 (/ISS) P18563 (/ISS)
Showing 1 to 10 of 90 entries
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