CATH Superfamily 1.25.40.420
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 18: Kelch-like family member 22
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q53GT1 (/IPI) Q53GT1 (/IPI) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
2 | Q53GT1 (/IPI) Q53GT1 (/IPI) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
1 | Q99JN2 (/ISO) |
There are 29 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitotic sister chromatid segregation GO:0000070
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
|
4 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q08CY1 (/ISS) Q99JN2 (/ISS) |
|
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
|
4 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q08CY1 (/ISS) Q99JN2 (/ISS) |
|
Mitotic spindle assembly checkpoint GO:0007094
A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
|
4 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q08CY1 (/ISS) Q99JN2 (/ISS) |
|
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
|
4 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q08CY1 (/ISS) Q99JN2 (/ISS) |
|
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
3 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q99JN2 (/ISS) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
3 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q99JN2 (/ISS) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
3 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q99JN2 (/ISS) |
|
Cellular response to leucine GO:0071233
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.
|
3 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q99JN2 (/ISS) |
|
Positive regulation of TORC1 signaling GO:1904263
Any process that activates or increases the frequency, rate or extent of TORC1 signaling.
|
3 | Q53GT1 (/IMP) Q53GT1 (/IMP) Q99JN2 (/IMP) |
|
Positive regulation of TORC1 signaling GO:1904263
Any process that activates or increases the frequency, rate or extent of TORC1 signaling.
|
3 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q99JN2 (/ISS) |
|
Mitotic sister chromatid segregation GO:0000070
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
|
2 | Q53GT1 (/IMP) Q53GT1 (/IMP) |
|
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
|
2 | Q53GT1 (/IDA) Q53GT1 (/IDA) |
|
Mitotic spindle assembly checkpoint GO:0007094
A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
|
2 | Q53GT1 (/IMP) Q53GT1 (/IMP) |
|
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
2 | Q53GT1 (/IMP) Q53GT1 (/IMP) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
2 | Q53GT1 (/IMP) Q53GT1 (/IMP) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
2 | Q53GT1 (/IMP) Q53GT1 (/IMP) |
|
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
|
2 | Q53GT1 (/TAS) Q53GT1 (/TAS) |
|
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
|
2 | Q53GT1 (/IMP) Q53GT1 (/IMP) |
|
Cellular response to leucine GO:0071233
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.
|
2 | Q53GT1 (/IMP) Q53GT1 (/IMP) |
|
Mitotic sister chromatid segregation GO:0000070
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
|
1 | Q99JN2 (/ISO) |
|
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
|
1 | Q99JN2 (/ISO) |
|
Mitotic spindle assembly checkpoint GO:0007094
A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
|
1 | Q99JN2 (/ISO) |
|
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | Q99JN2 (/ISO) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
1 | Q99JN2 (/ISO) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | Q99JN2 (/ISO) |
|
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
|
1 | Q99JN2 (/ISO) |
|
Cellular response to amino acid stimulus GO:0071230
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
|
1 | Q99JN2 (/IMP) |
|
Cellular response to leucine GO:0071233
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.
|
1 | Q99JN2 (/ISO) |
|
Positive regulation of TORC1 signaling GO:1904263
Any process that activates or increases the frequency, rate or extent of TORC1 signaling.
|
1 | Q99JN2 (/ISO) |
There are 19 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q08CY1 (/ISS) Q99JN2 (/ISS) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
4 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q08CY1 (/ISS) Q99JN2 (/ISS) |
|
Polar microtubule GO:0005827
Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart.
|
4 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q08CY1 (/ISS) Q99JN2 (/ISS) |
|
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
|
4 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q08CY1 (/ISS) Q99JN2 (/ISS) |
|
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
|
4 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q08CY1 (/ISS) Q99JN2 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | D2HEW7 (/ISS) D3ZZC3 (/ISS) Q99JN2 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q53GT1 (/IDA) Q53GT1 (/IDA) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
2 | Q53GT1 (/IDA) Q53GT1 (/IDA) |
|
Polar microtubule GO:0005827
Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart.
|
2 | Q53GT1 (/IDA) Q53GT1 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q53GT1 (/IDA) Q53GT1 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q53GT1 (/TAS) Q53GT1 (/TAS) |
|
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
|
2 | Q53GT1 (/IDA) Q53GT1 (/IDA) |
|
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
|
2 | Q53GT1 (/IDA) Q53GT1 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q99JN2 (/ISO) |
|
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
1 | Q99JN2 (/ISO) |
|
Polar microtubule GO:0005827
Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart.
|
1 | Q99JN2 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q99JN2 (/ISO) |
|
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
|
1 | Q99JN2 (/ISO) |
|
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
|
1 | Q99JN2 (/ISO) |
