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CATH Superfamily 1.20.900.10

Dbl homology (DH) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Dbl homology (DH) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Guanine nucleotide exchange factor DBS
885
3D
 2nz8B01 - 80.1
2
Rho guanine nucleotide exchange factor 9
823
3D
 2pz1A02 - 74.7
3
Rho guanine nucleotide exchange factor 10 like
655 - - 92.0
4
Rho guanine nucleotide exchange factor 2
601
3D
 4d0oB00 - 90.8
6
Rho guanine nucleotide exchange factor
GEF
544
3D
 5jhhE01 - 89.1
5
Ras-specific guanine nucleotide-releasing factor 1 isoform 2
543 - - 48.2
7
rho guanine nucleotide exchange factor 19
507 - - 93.1
8
rho guanine nucleotide exchange factor 25
454
3D
 2rgnE01 - 89.2
9
Vav guanine nucleotide exchange factor 1
409
3D
 2vrwB01 - 80.4
10
Rho guanine nucleotide exchange factor 3 isoform 1
358
3D
 2z0qA01 - 60.9
11
Intersectin 1
307
3D
 5hziB01 - 73.4
12
T cell lymphoma invasion and metastasis 1
301
3D
 1foeG01 - 64.9
13
FYVE, RhoGEF and PH domain-containing protein 4
288 - - 73.2
14
active breakpoint cluster region-related protein isoform X2
254 - - 59.0
15
son of sevenless homolog 1 isoform X1
245
3D
 3ksyA02 - 82.3
16
Rho guanine nucleotide exchange factor 6
242
3D
 1by1A00 - 81.2
18
Phosphatidylinositol-3,4, 5-trisphosphate-dependent Rac exchange factor 2, putative
221
3D
 5fi1A01 - 76.4
17
pleckstrin homology domain-containing family G member 5 isoform X1
217 - - 74.4
19
Pleckstrin homology domain-containing family G member 1
203 - - 81.3
20
FERM, RhoGEF and pleckstrin domain-containing protein 2
198
3D
 4gzuB01 - 65.9
21
FERM, RhoGEF and pleckstrin domain-containing protein 1
174 - - 88.0
22
protein ECT2 isoform X1
172 - - 63.8
23
dynamin-binding protein isoform X2
161 - - 77.2
24
FYVE, RhoGEF and PH domain-containing protein 6
143
3D
 3mpxA01 - 75.1
25
Rho guanine nucleotide exchange factor 17
92 - - 68.6
26
Alsin isoform X1
80 - - 48.1
27
Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
77 - - 71.9
28
Puratrophin-1-like, isoform D
61 - - 59.9
29
Rho guanine nucleotide exchange factor 37
57 - - 74.4
30
rho guanine nucleotide exchange factor 39
55 - - 54.5
31
Uncharacterized protein, isoform B
46 - - 21.3
32
rho guanine nucleotide exchange factor 38
41 - - 71.1
33
Muscle M-line assembly protein unc-89-like Protein
37 - - 71.1
34
Uncharacterized protein, isoform B
35 - - 13.8
36
EG:23E12.2, isoform B
32 - - 37.4
35
Rho guanyl nucleotide exchange factor
32 - - 79.0
37
Protostome-specific GEF, isoform C
31 - - 19.2
38
Myosin-M heavy chain
28 - - 91.7
39
Uncharacterized protein, isoform C
27 - - 4.5
40
Trio, isoform D
27 - - 16.3
42
uncharacterized protein LOC108093793 isoform X3
24 - - 12.8
41
Rho guanyl nucleotide exchange factor
24 - - 64.2
43
ALS2 C-terminal like
22 - - 38.0
44
Uncharacterized protein, isoform B
21 - - 16.2
45
Uncharacterized protein, isoform C
20 - - 55.6
46
Related to CDC24-GTP/GDP exchange factor for Cdc42p
20 - - 73.4
47
Uncharacterized protein, isoform A
17 - - 17.5
48
GL21162
17 - - 24.4
49
Rho guanine nucleotide exchange factor 38
17 - - 29.0
50
Guanine nucleotide exchange factor
16 - - 57.4
51
Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
15 - - 36.4
52
Cell division control protein 24
13 - - 13.5
54
CDC-42 Guanine nucleotide Exchange Factor
13 - - 17.5
53
Rho guanyl nucleotide exchange factor, putative
13 - - 76.6
55
UNC-112-Interacting Guanine nucleotide exchange factor
12 - - 8.3
57
Rho guanine nucleotide exchange factor 38
11 - - 20.7
56
TOR unique function suppressor
11 - - 10.0
60
Rho guanine nucleotide exchange factor osg-1
9 - - 30.8
58
Uncharacterized protein, isoform A
9 - - 4.7
59
Protein CBG22463
9 - - 19.5
63
Rho guanine nucleotide exchange factor
GEF
8 - - 91.1
61
TIAM
Mammalian Tumor Invasion And Metastasis factor
8 - - 7.6
62
Unplaced genomic scaffold supercont1.14, whole genome shotgun sequence
8 - - 14.1
64
Muscle M-line assembly protein unc-89
7 - - 3.3
66
RhoGAP domain containing protein
7 - - 10.9
65
T-cell activation Rho GTPase activating protein, putative
7 - - 3.9
67
Rho guanyl nucleotide exchange factor, putative
AFU_orthologue AFUA_5G11890
6 - - 19.9
69
Uncharacterized protein
6 - - 0.0
68
FUS2p Cell fusion regulator
6 - - 1.4
70
FERM domain
Protein4.1-ezrin-radixin-moesin
5 - - 15.1
72
Putative Rho guanine nucleotide exchange factor FGD-1
4 - - 0.0
73
Putative RhoGEF group protein
4 - - 5.7
71
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform a
4 - - 39.7
74
RHo Guanine nucleotide exchange Factor
3 - - 0.0
77
Uncharacterized protein
3 - - 0.0
79
Obscurin
3 - - 14.0
75
Rho guanine nucleotide exchange factor 38
3 - - 12.8
78
Guanine nucleotide exchange factor UNC-73B
3 - - 0.0
76
Uncharacterized protein
3 - - 20.7
80
FERM, ARHGEF and pleckstrin domain-containing protein 1
3 - - 2.6
88
Putative rho guanine nucleotide exchange factor cdep
2 - - 10.0
85
Uncharacterized protein
2 - - 43.2
96
Uncharacterized protein
2 - - 39.4
89
PIX
PAK (p21-activated kinase
2 - - 0.0
95
Rho GTPase-activating protein 20
2 - - 0.0
86
Uncharacterized protein
2 - - 19.1
82
Uncharacterized protein
2 - - 0.0
91
Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
2 - - 4.9
84
Kalirin RhoGEF kinase a
2 - - 43.8
93
ECT2
Mammalian Rho GEF
2 - - 0.0
90
YALI0F13673p
2 - - 0.0
87
FERM, ARH/RhoGEF and pleckstrin domain protein 2
2 - - 6.8
92
Son of sevenless homolog
2 - - 0.0
81
Protein ECT2
2 - - 43.5
83
Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF a
2 - - 6.4
94
Dynamin-binding protein
2 - - 0.0
102
MKIAA0380 protein
1 - - 0.0
119
Uncharacterized protein
1 - - 0.0
106
Uncharacterized protein
1 - - 0.0
121
Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b
1 - - 0.0
116
Rho guanine nucleotide exchange factor gef2
1 - - 0.0
109
Uncharacterized protein
1 - - 0.0
112
RH56938p
1 - - 0.0
124
Uncharacterized protein
1 - - 0.0
132
Predicted protein
1 - - 0.0
128
Son of sevenless 1
1 - - 0.0
136
Predicted protein
1 - - 0.0
114
Uncharacterized protein
1 - - 0.0
118
Uncharacterized protein
1 - - 0.0
98
AT26020p
1 - - 0.0
126
Kalirin RhoGEF kinase a
1 - - 0.0
122
Uncharacterized protein
1 - - 0.0
134
BAR domaincontaining protein
1 - - 0.0
131
Uncharacterized protein
1 - - 0.0
111
Protein CBG05206
1 - - 0.0
99
Rho1 guanine nucleotide exchange factor 3
1 - - 0.0
101
Rho guanine nucleotide exchange factor
GEF
1 - - 0.0
129
Predicted protein
1 - - 0.0
108
Uncharacterized protein
1 - - 0.0
104
Uncharacterized protein
1 - - 0.0
115
Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
1 - - 0.0
135
Predicted protein
1 - - 0.0
103
Meiotically up-regulated gene 10 protein
1 - - 0.0
100
Uncharacterized protein
1 - - 0.0
133
Probable serine/threonine-protein kinase roco5
1 - - 0.0
130
Rho GTPase regulating protein, putative
1 - - 0.0
127
Uncharacterized protein
1 - - 0.0
110
GH01987p
1 - - 0.0
113
Chromosome 7, whole genome shotgun sequence
1 - - 0.0
105
Uncharacterized protein
1 - - 0.0
120
Rho guanine nucleotide exchange factor 37
1 - - 0.0
97
MKIAA1209 protein
1 - - 0.0
123
Uncharacterized protein
1 - - 0.0
117
Rac guanine nucleotide exchange factor B
1 - - 0.0
107
Predicted protein
1 - - 0.0
125
Uncharacterized protein
1 - - 0.0
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