The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1425 - - 94.8
2
1340
3D
5ojmE02 - 82.2
3
997
3D
4x5tD02 - 81.0
4
948
3D
4cofE02 - 59.2
133
711
3D
6i08E02 - 98.7
5
675 - - 95.8
6
616 - - 67.0
7
556 - - 79.4
8
449
3D
2lm2A01 - 77.2
9
373 - - 86.6
10
343 - - 86.5
11
282 - - 88.7
12
257 - - 84.1
13
248 - - 55.3
14
240 - - 75.4
15
GABA-A
204 - - 66.7
16
184 - - 81.2
17
181 - - 81.9
24
179
3D
4tnwT02 - 82.3
19
GABA
169 - - 72.1
18
169 - - 38.1
20
serotonin
156 - - 85.8
21
155 - - 40.8
22
142 - - 96.1
23
139 - - 76.1
25
117 - - 63.0
26
115 - - 69.7
27
113 - - 69.0
28
112 - - 54.3
30
111 - - 94.1
29
111 - - 80.6
31
109
3D
2bg9B02 - 55.1
32
106 - - 92.9
34
100 - - 81.0
33
100 - - 72.2
35
98 - - 93.3
36
96 - - 81.0
37
95 - - 72.9
38
93 - - 77.5
39
88 - - 86.3
40
76 - - 74.3
41
75 - - 78.1
42
70 - - 71.9
43
69 - - 97.9
44
67 - - 95.2
45
61 - - 60.3
46
60 - - 89.4
47
59 - - 52.8
48
57 - - 85.8
49
54 - - 81.7
50
47 - - 67.0
51
42 - - 72.4
52
40
3D
2bg9D02 - 72.7
53
38 - - 77.1
56
37 - - 74.7
55
37 - - 81.3
54
GABA-A
37 - - 58.8
57
35 - - 17.7
58
33 - - 64.8
59
31 - - 41.8
60
30 - - 89.8
61
29 - - 82.0
62
29 - - 31.8
63
28 - - 68.5
64
27 - - 78.9
66
25 - - 38.1
65
25 - - 73.5
67
24 - - 93.4
69
23 - - 59.2
68
23 - - 67.3
70
22 - - 61.4
73
20 - - 88.9
72
20 - - 75.1
71
20 - - 54.8
75
19 - - 97.6
76
19 - - 89.0
74
19 - - 74.0
77
18 - - 15.4
78
18 - - 84.9
79
17 - - 45.1
80
serotonin
16 - - 77.7
81
16 - - 68.9
82
15 - - 76.9
83
14 - - 57.9
84
14 - - 75.6
86
14 - - 68.0
85
14 - - 6.6
88
13 - - 83.3
87
13 - - 38.8
93
12 - - 90.9
92
12 - - 97.1
89
12 - - 45.5
90
12 - - 80.5
91
12 - - 24.4
97
GABA
11 - - 43.3
98
11 - - 84.7
95
11 - - 75.5
96
11 - - 72.2
94
11 - - 25.6
101
10 - - 75.4
100
10 - - 85.5
99
10 - - 96.4
107
9 - - 9.5
105
9 - - 41.3
104
9 - - 21.5
103
9 - - 71.6
106
9 - - 16.5
109
9 - - 52.6
108
9 - - 42.0
102
9 - - 30.2
114
8 - - 85.4
111
8 - - 22.2
112
8 - - 6.5
113
8 - - 69.1
110
8 - - 79.6
121
7 - - 93.0
115
See gbr
7 - - 26.6
124
7 - - 67.1
117
7 - - 77.1
118
7 - - 79.2
123
7 - - 69.4
120
7 - - 46.8
122
7 - - 49.4
119
7 - - 9.7
116
7 - - 32.2
131
6 - - 79.4
127
6 - - 19.5
125
6 - - 9.0
126
6 - - 15.1
129
6 - - 9.8
130
6 - - 95.0
128
6 - - 75.3
132
6 - - 89.7
145
5 - - 71.8
137
5 - - 72.7
144
5 - - 89.8
134
5 - - 12.9
141
5 - - 86.2
135
5 - - 37.8
139
5 - - 23.7
136
5 - - 55.6
142
5 - - 55.6
143
5 - - 45.1
140
5 - - 59.6
138
5 - - 82.8
154
4 - - 5.6
155
4 - - 10.0
147
4 - - 61.4
151
4 - - 23.6
157
4 - - 18.8
152
See gbr
4 - - 55.7
158
4 - - 60.9
148
4 - - 65.6
156
4 - - 28.9
159
4 - - 69.5
150
4 - - 15.6
160
serotonin
4 - - 41.6
146
4 - - 37.4
153
4 - - 17.8
149
4 - - 73.5
164
3 - - 79.1
171
3 - - 71.9
177
3 - - 47.0
165
3 - - 4.7
161
3 - - 50.4
174
3 - - 40.0
175
3 - - 70.1
167
3 - - 3.1
176
3 - - 72.8
168
3 - - 4.3
179
3 - - 55.2
180
3 - - 47.2
162
3 - - 63.9
170
3 - - 42.4
173
3 - - 71.6
172
3 - - 59.4
178
3 - - 75.8
166
3 - - 41.6
169
3 - - 33.7
163
3 - - 44.7
213
2 - - 0.0
232
2 - - 27.8
228
2 - - 39.2
196
2 - - 43.3
222
2 - - 30.9
187
2 - - 36.8
199
2 - - 4.8
210
2 - - 0.0
208
2 - - 38.2
181
2 - - 7.3
193
2 - - 41.8
219
GABA
2 - - 40.5
190
2 - - 42.0
216
2 - - 0.0
202
2 - - 8.5
198
2 - - 0.0
203
2 - - 1.3
200
2 - - 7.9
226
2 - - 40.1
185
2 - - 23.3
229
2 - - 41.1
192
2 - - 43.2
218
2 - - 35.6
230
2 - - 51.8
223
2 - - 38.6
220
2 - - 2.0
212
2 - - 0.0
206
2 - - 31.3
209
2 - - 43.5
184
2 - - 32.5
191
2 - - 39.7
183
2 - - 34.2
224
2 - - 34.8
217
2 - - 27.4
205
2 - - 0.0
211
2 - - 5.4
204
2 - - 12.8
189
2 - - 33.7
197
2 - - 49.8
225
2 - - 39.0
186
GABA
2 - - 32.6
221
2 - - 10.2
215
2 - - 0.0
207
2 - - 40.9
194
2 - - 38.8
231
2 - - 40.7
201
2 - - 9.2
188
2 - - 35.6
227
2 - - 40.9
182
2 - - 14.3
195
gene/pseudogene
2 - - 43.1
214
2 - - 6.6
334
1 - - 0.0
256
1 - - 0.0
259
1 - - 0.0
272
1 - - 0.0
243
1 - - 0.0
317
1 - - 0.0
278
1 - - 0.0
294
1 - - 0.0
240
1 - - 0.0
305
1 - - 0.0
266
1 - - 0.0
324
1 - - 0.0
269
1 - - 0.0
238
1 - - 0.0
250
1 - - 0.0
311
1 - - 0.0
288
1 - - 0.0
263
1 - - 0.0
246
1 - - 0.0
260
1 - - 0.0
325
1 - - 0.0
282
1 - - 0.0
304
1 - - 0.0
295
1 - - 0.0
253
1 - - 0.0
249
1 - - 0.0
239
1 - - 0.0
276
1 - - 0.0
268
1 - - 0.0
291
1 - - 0.0
283
1 - - 0.0
321
1 - - 0.0
252
1 - - 0.0
279
1 - - 0.0
236
1 - - 0.0
331
1 - - 0.0
258
1 - - 0.0
315
1 - - 0.0
280
1 - - 0.0
262
1 - - 0.0
307
1 - - 0.0
248
1 - - 0.0
270
1 - - 0.0
301
1 - - 0.0
297
1 - - 0.0
289
1 - - 0.0
233
1 - - 0.0
314
1 - - 0.0
273
1 - - 0.0
242
1 - - 0.0
327
1 - - 0.0
286
1 - - 0.0
298
1 - - 0.0
261
1 - - 0.0
274
1 - - 0.0
313
1 - - 0.0
234
1 - - 0.0
332
1 - - 0.0
328
1 - - 0.0
251
1 - - 0.0
247
1 - - 0.0
310
1 - - 0.0
322
1 - - 0.0
285
1 - - 0.0
292
1 - - 0.0
257
1 - - 0.0
241
1 - - 0.0
235
1 - - 0.0
275
1 - - 0.0
308
1 - - 0.0
316
1 - - 0.0
267
1 - - 0.0
302
1 - - 0.0
284
1 - - 0.0
319
1 - - 0.0
254
1 - - 0.0
303
1 - - 0.0
264
1 - - 0.0
296
1 - - 0.0
329
1 - - 0.0
271
1 - - 0.0
300
1 - - 0.0
245
1 - - 0.0
299
1 - - 0.0
326
1 - - 0.0
287
1 - - 0.0
330
1 - - 0.0
277
1 - - 0.0
318
1 - - 0.0
323
1 - - 0.0
281
1 - - 0.0
293
1 - - 0.0
255
1 - - 0.0
237
1 - - 0.0
309
1 - - 0.0
244
1 - - 0.0
290
1 - - 0.0
312
1 - - 0.0
320
1 - - 0.0
333
1 - - 0.0
306
1 - - 0.0
265
1 - - 0.0
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