×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

View in Gene3D

CATH Superfamily 1.20.58.390

Neurotransmitter-gated ion-channel transmembrane domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Neuronal nicotinic acetylcholine receptor subunit 3
1425 - - 94.8
2
Putative gamma-aminobutyric acid receptor subunit alpha-5
1340
3D
 5ojmE02 - 82.2
3
Glycine receptor alpha 2 subunit
997
3D
 4x5tD02 - 81.0
4
Gamma-aminobutyric acid receptor subunit beta-2 isoform A
948
3D
 4cofE02 - 59.2
133
Proton-gated ion channel
711
3D
 6i08E02 - 98.7
5
Putative gamma-aminobutyric acid receptor subunit rho-2-like
675 - - 95.8
6
Putative gamma-aminobutyric acid receptor subunit gamma-2
616 - - 67.0
7
Neuronal acetylcholine receptor subunit alpha-7
556 - - 79.4
8
Cholinergic receptor nicotinic beta 4 subunit
449
3D
 2lm2A01 - 77.2
9
Cholinergic receptor nicotinic alpha 9 subunit
373 - - 86.6
10
Nicotinic acetylcholine receptor subunit epsilon
343 - - 86.5
11
neuronal acetylcholine receptor subunit alpha-7
282 - - 88.7
12
Acetylcholine receptor subunit alpha-like
257 - - 84.1
13
Putative acetylcholine receptor subunit alpha
248 - - 55.3
14
Neuronal nicotinic acetylcholine receptor alpha4 subunit
240 - - 75.4
15
Gamma-aminobutyric acid
GABA-A
204 - - 66.7
16
Putative acetylcholine receptor subunit alpha
184 - - 81.2
17
Neuronal acetylcholine receptor subunit alpha-3
181 - - 81.9
24
Glutamate-gated chloride channel alpha
179
3D
 4tnwT02 - 82.3
19
Gamma-aminobutyric acid
GABA
169 - - 72.1
18
Glycine receptor subunit beta
169 - - 38.1
20
5-hydroxytryptamine
serotonin
156 - - 85.8
21
glutamate-gated chloride channel isoform X12
155 - - 40.8
22
Nicotinic acetylcholine receptor subunit alpha4
142 - - 96.1
23
Nicotinic acetylcholine receptor subunit alpha6
139 - - 76.1
25
Cholinergic receptor nicotinic beta 3 subunit
117 - - 63.0
26
Cholinergic receptor nicotinic beta 1 subunit
115 - - 69.7
27
Histamine-gated chloride channel subunit
113 - - 69.0
28
Cholinergic receptor nicotinic beta 2 subunit
112 - - 54.3
29
acetylcholine receptor subunit delta isoform X1
111 - - 80.6
30
Acetylcholine receptor subunit alpha-L1
111 - - 94.1
31
Cholinergic receptor nicotinic beta 1 subunit
109
3D
 2bg9B02 - 55.1
32
gamma-aminobutyric acid receptor subunit epsilon
106 - - 92.9
33
Gamma-aminobutyric acid receptor subunit beta
100 - - 72.2
34
Cholinergic receptor nicotinic beta 4 subunit
100 - - 81.0
35
Acetylcholine receptor subunit beta-like 1
98 - - 93.3
36
Nicotinic acetylcholine receptor subunit gamma
96 - - 81.0
37
Nicotinic acetylcholine receptor subunit alpha6
95 - - 72.9
38
Acetylcholine receptor subunit beta-like 1
93 - - 77.5
39
Ligand-Gated ion Channel
88 - - 86.3
40
Gamma-aminobutyric acid receptor subunit beta-like
76 - - 74.3
41
Neuronal acetylcholine receptor subunit alpha-5
75 - - 78.1
42
5-hydroxytryptamine receptor 3C
70 - - 71.9
43
AcetylCholine Receptor
69 - - 97.9
44
neuronal acetylcholine receptor subunit alpha-9
67 - - 95.2
45
neuronal acetylcholine receptor subunit alpha-10
61 - - 60.3
46
AcetylCholine Receptor
60 - - 89.4
47
Resistance to dieldrin, isoform H
59 - - 52.8
48
Cholinergic receptor nicotinic epsilon subunit
57 - - 85.8
49
AcetylCholine Receptor
54 - - 81.7
50
glycine receptor subunit alpha-4
47 - - 67.0
51
Cholinergic receptor, nicotinic, alpha 6
42 - - 72.4
52
Cholinergic receptor nicotinic alpha 1 subunit
40
3D
 2bg9D02 - 72.7
53
Neuronal acetylcholine receptor subunit alpha-9
38 - - 77.1
56
5-hydroxytryptamine receptor 3B
37 - - 74.7
54
Gamma-aminobutyric acid
GABA-A
37 - - 58.8
55
Ligand-Gated ion Channel
37 - - 81.3
57
Resistance to dieldrin, isoform E
35 - - 17.7
58
Nicotinic acetylcholine receptor alpha6, isoform D
33 - - 64.8
59
Nicotinic acetylcholine receptor alpha6, isoform D
31 - - 41.8
60
Ligand-Gated ion Channel
30 - - 89.8
62
Neurotransmitter-gated ion-channel transmembrane region
29 - - 31.8
61
Ligand-Gated ion Channel
29 - - 82.0
63
AcetylCholine Receptor
28 - - 68.5
64
Neuronal acetylcholine receptor subunit alpha-7
27 - - 78.9
66
Acetylcholine receptor subunit alpha-type unc-63
25 - - 38.1
65
GABA-gated ion channel
25 - - 73.5
67
Glycine receptor subunit alpha-2
24 - - 93.4
69
Ligand-Gated ion Channel
23 - - 59.2
68
zinc-activated ligand-gated ion channel
23 - - 67.3
70
Glycine receptor beta
22 - - 61.4
73
Neuronal acetylcholine receptor subunit alpha-9-II
20 - - 88.9
71
Ligand-Gated ion Channel
20 - - 54.8
72
Uncharacterized protein
20 - - 75.1
75
Neuronal acetylcholine receptor subunit alpha-9-II
19 - - 97.6
76
Glutamate-gated chloride channel, putative
19 - - 89.0
74
Gamma-aminobutyric acid type A receptor gamma2 subunit
19 - - 74.0
77
Ligand-gated ion channel 50
18 - - 15.4
78
AcetylCholine Receptor
18 - - 84.9
79
Cholinergic receptor, nicotinic, epsilon
17 - - 45.1
81
Proton-gated ion channel subunit pbo-5
16 - - 68.9
80
5-hydroxytryptamine
serotonin
16 - - 77.7
82
Glutamate-gated ChLoride channel
15 - - 76.9
85
Gamma-aminobutyric acid type A receptor pi subunit
14 - - 6.6
83
Ligand-Gated ion Channel
14 - - 57.9
84
Glutamate-gated chloride channel subunit beta
14 - - 75.6
86
Acetylcholine receptor subunit beta-type acr-2
14 - - 68.0
88
Uncharacterized protein
13 - - 83.3
87
GABA-gated ion channel
13 - - 38.8
90
Ligand-Gated ion Channel
12 - - 80.5
92
Nicotinic acetylcholine receptor subunit alpha10
12 - - 97.1
89
Ligand-Gated ion Channel
12 - - 45.5
91
Glycine receptor, beta a
12 - - 24.4
93
Uncharacterized protein
12 - - 90.9
94
Ligand-Gated ion Channel
11 - - 25.6
96
Ligand-Gated ion Channel
11 - - 72.2
98
Predicted protein
11 - - 84.7
95
Ionotropic GABA receptor subunit UNC-49B.3
11 - - 75.5
97
Gamma-aminobutyric acid
GABA
11 - - 43.3
101
Uncharacterized protein
10 - - 75.4
100
Predicted protein
10 - - 85.5
99
Cholinergic receptor, nicotinic, epsilon
10 - - 96.4
107
AcetylCholine Receptor
9 - - 9.5
109
AcetylCholine Receptor
9 - - 52.6
108
Uncharacterized protein
9 - - 42.0
105
AcetylCholine Receptor
9 - - 41.3
104
AcetylCholine Receptor
9 - - 21.5
102
Glycine receptor subunit beta-type 4
9 - - 30.2
106
ACHA7
9 - - 16.5
103
Si:ch211-256e16.10
9 - - 71.6
110
Uncharacterized protein
8 - - 79.6
113
Ionotropic GABA receptor subunit UNC-49Cshort
8 - - 69.1
112
Acetylcholine receptor subunit alpha-type unc-63
8 - - 6.5
114
Uncharacterized protein
8 - - 85.4
111
AcetylCholine Receptor
8 - - 22.2
121
Uncharacterized protein
7 - - 93.0
116
Gamma-aminobutyric acid type A receptor beta2 subunit
7 - - 32.2
124
Protein CBG26995
7 - - 67.1
115
GABA/Glycine Receptor family
See gbr
7 - - 26.6
118
GABA-gated ion channel
7 - - 79.2
122
Uncharacterized protein
7 - - 49.4
119
AcetylCholine Receptor
7 - - 9.7
120
5-hydroxytryptamine receptor 3A
7 - - 46.8
123
Uncharacterized protein
7 - - 69.4
117
Uncharacterized protein
7 - - 77.1
130
Si:ch211-256e16.7
6 - - 95.0
127
AcetylCholine Receptor
6 - - 19.5
129
AcetylCholine Receptor
6 - - 9.8
125
Acetylcholine-gated ion channel acc-4
6 - - 9.0
132
Uncharacterized protein
6 - - 89.7
128
Neuronal acetylcholine receptor subunit eat-2
6 - - 75.3
126
Ligand-Gated ion Channel
6 - - 15.1
131
Predicted protein
6 - - 79.4
145
Predicted protein
5 - - 71.8
144
Protein CBR-ACR-25
5 - - 89.8
141
Predicted protein
5 - - 86.2
136
Ligand-Gated ion Channel
5 - - 55.6
139
AcetylCholine Receptor
5 - - 23.7
143
5-hydroxytryptamine receptor 3D
5 - - 45.1
140
Neuronal acetylcholine receptor subunit eat-2
5 - - 59.6
138
Predicted protein
5 - - 82.8
135
Ligand-Gated ion Channel
5 - - 37.8
134
Ligand-Gated ion Channel
5 - - 12.9
137
Predicted protein
5 - - 72.7
142
Uncharacterized protein
5 - - 55.6
149
Uncharacterized protein
4 - - 73.5
148
Transmembrane ion channel
4 - - 65.6
156
Uncharacterized protein
4 - - 28.9
152
GABA/Glycine Receptor family
See gbr
4 - - 55.7
150
Neurotransmitter-gated ion-channel ligand binding domain protein
4 - - 15.6
147
Uncharacterized protein
4 - - 61.4
153
Acetylcholine receptor subunit alpha-type acr-7
4 - - 17.8
160
5-hydroxytryptamine
serotonin
4 - - 41.6
157
Ionotropic GABA receptor subunit UNC-49C
4 - - 18.8
151
AcetylCholine Receptor
4 - - 23.6
159
Acetylcholine receptor subunit alpha-type acr-16
4 - - 69.5
155
Nicotinic acetylcholine receptor subunit
4 - - 10.0
154
CBN-LEV-8 protein
4 - - 5.6
158
Nicotinic acetylcholine receptor subunit
4 - - 60.9
146
Uncharacterized protein
4 - - 37.4
169
Uncharacterized protein
3 - - 33.7
168
Cholinergic receptor nicotinic beta 1 subunit
3 - - 4.3
170
Predicted protein
3 - - 42.4
165
AGAP007707-PA
3 - - 4.7
173
Predicted protein
3 - - 71.6
164
Predicted protein
3 - - 79.1
176
Predicted protein
3 - - 72.8
167
Nicotinic acetylcholine receptor subunit
3 - - 3.1
161
Uncharacterized protein
3 - - 50.4
172
Uncharacterized protein
3 - - 59.4
180
Uncharacterized protein
3 - - 47.2
174
Nicotinic acetylcholine receptor subunit
3 - - 40.0
163
Acetylcholine receptor subunit alpha
3 - - 44.7
175
Predicted protein
3 - - 70.1
178
Predicted protein
3 - - 75.8
179
Predicted protein
3 - - 55.2
162
Uncharacterized protein
3 - - 63.9
171
Glycine receptor alpha 1 variant, putative
3 - - 71.9
177
Uncharacterized protein
3 - - 47.0
166
Uncharacterized protein
3 - - 41.6
215
Nicotinic acetylcholine receptor subunit
2 - - 0.0
190
Uncharacterized protein
2 - - 42.0
186
Gamma-aminobutyric acid
GABA
2 - - 32.6
214
Uncharacterized protein
2 - - 6.6
218
Uncharacterized protein
2 - - 35.6
182
Predicted protein
2 - - 14.3
193
Predicted protein
2 - - 41.8
202
Transmembrane ion channel
2 - - 8.5
226
Predicted protein
2 - - 40.1
222
Uncharacterized protein
2 - - 30.9
219
Gamma-aminobutyric acid
GABA
2 - - 40.5
206
Uncharacterized protein
2 - - 31.3
203
Predicted protein
2 - - 1.3
231
Uncharacterized protein
2 - - 40.7
220
Uncharacterized protein
2 - - 2.0
223
Predicted protein
2 - - 38.6
200
Uncharacterized protein
2 - - 7.9
196
Uncharacterized protein
2 - - 43.3
183
Uncharacterized protein
2 - - 34.2
211
Uncharacterized protein
2 - - 5.4
192
Predicted protein
2 - - 43.2
217
Uncharacterized protein
2 - - 27.4
207
Cholinergic receptor nicotinic delta subunit
2 - - 40.9
201
Gamma-aminobutyric acid type A receptor pi subunit
2 - - 9.2
227
Glycine receptor alpha chain, putative
2 - - 40.9
199
Ligand-gated ion channel
2 - - 4.8
221
AcetylCholine Receptor
2 - - 10.2
230
Uncharacterized protein
2 - - 51.8
210
Nicotinic acetylcholine receptor subunit
2 - - 0.0
195
Gamma-aminobutyric acid type A receptor rho3 subunit
gene/pseudogene
2 - - 43.1
194
Uncharacterized protein
2 - - 38.8
198
Transmembrane ion channel
2 - - 0.0
187
Ligand-Gated ion Channel
2 - - 36.8
181
Predicted protein
2 - - 7.3
213
Acr-19
2 - - 0.0
185
Uncharacterized protein
2 - - 23.3
184
Uncharacterized protein
2 - - 32.5
216
Nicotinic acetylcholine receptor subunit
2 - - 0.0
209
Cholinergic receptor nicotinic alpha 10 subunit
2 - - 43.5
188
Uncharacterized protein
2 - - 35.6
191
Predicted protein
2 - - 39.7
229
Uncharacterized protein
2 - - 41.1
197
Glutamate-gated chloride channel, putative
2 - - 49.8
212
Nicotinic acetylcholine receptor subunit
2 - - 0.0
224
Uncharacterized protein
2 - - 34.8
232
Uncharacterized protein
2 - - 27.8
208
Uncharacterized protein
2 - - 38.2
225
Predicted protein
2 - - 39.0
204
Neurotransmitter-gated ion-channel ligand binding domain protein
2 - - 12.8
189
Predicted protein
2 - - 33.7
205
Uncharacterized protein
2 - - 0.0
228
Uncharacterized protein
2 - - 39.2
243
Uncharacterized protein
1 - - 0.0
263
Glycine receptor alpha 1 variant, putative
1 - - 0.0
275
Uncharacterized protein
1 - - 0.0
313
Uncharacterized protein
1 - - 0.0
239
Uncharacterized protein
1 - - 0.0
274
Uncharacterized protein
1 - - 0.0
310
Uncharacterized protein
1 - - 0.0
257
Uncharacterized protein
1 - - 0.0
278
Uncharacterized protein
1 - - 0.0
251
Uncharacterized protein
1 - - 0.0
240
Uncharacterized protein
1 - - 0.0
299
Uncharacterized protein
1 - - 0.0
260
Glycine receptor alpha 4
1 - - 0.0
321
Uncharacterized protein
1 - - 0.0
294
Uncharacterized protein
1 - - 0.0
327
Uncharacterized protein
1 - - 0.0
330
Uncharacterized protein
1 - - 0.0
238
Gamma-aminobutyric acid type A receptor alpha6 subunit
1 - - 0.0
295
Cholinergic receptor nicotinic gamma subunit
1 - - 0.0
287
Predicted protein
1 - - 0.0
333
Uncharacterized protein
1 - - 0.0
279
Predicted protein
1 - - 0.0
301
AcetylCholine Receptor
1 - - 0.0
281
Uncharacterized protein
1 - - 0.0
307
Uncharacterized protein
1 - - 0.0
234
Uncharacterized protein
1 - - 0.0
235
Uncharacterized protein
1 - - 0.0
298
Hypothetical protein LOC100135106
1 - - 0.0
284
Uncharacterized protein
1 - - 0.0
304
Uncharacterized protein
1 - - 0.0
237
Uncharacterized protein
1 - - 0.0
285
Uncharacterized protein
1 - - 0.0
305
Uncharacterized protein
1 - - 0.0
328
Uncharacterized protein
1 - - 0.0
291
Uncharacterized protein
1 - - 0.0
332
Uncharacterized protein
1 - - 0.0
297
Uncharacterized protein
1 - - 0.0
324
Uncharacterized protein
1 - - 0.0
288
Uncharacterized protein
1 - - 0.0
308
Protein CBR-ACR-3
1 - - 0.0
325
Uncharacterized protein
1 - - 0.0
259
Uncharacterized protein
1 - - 0.0
242
AGAP009493-PA
1 - - 0.0
262
Uncharacterized protein
1 - - 0.0
254
Uncharacterized protein
1 - - 0.0
255
Uncharacterized protein
1 - - 0.0
312
Protein CBG01449
1 - - 0.0
329
Uncharacterized protein
1 - - 0.0
246
Uncharacterized protein
1 - - 0.0
266
Uncharacterized protein
1 - - 0.0
258
Uncharacterized protein
1 - - 0.0
309
Uncharacterized protein
1 - - 0.0
271
Uncharacterized protein
1 - - 0.0
289
Cholinergic receptor, nicotinic, alpha polypeptide 9
1 - - 0.0
277
Uncharacterized protein
1 - - 0.0
316
Uncharacterized protein
1 - - 0.0
334
Uncharacterized protein
1 - - 0.0
306
Uncharacterized protein
1 - - 0.0
319
Uncharacterized protein
1 - - 0.0
322
Uncharacterized protein
1 - - 0.0
233
Protein CBR-LGC-39
1 - - 0.0
286
GABA-A receptor epsilon subunit
1 - - 0.0
290
Uncharacterized protein
1 - - 0.0
249
Uncharacterized protein
1 - - 0.0
269
Zinc activated ion channel
1 - - 0.0
326
Uncharacterized protein
1 - - 0.0
282
Uncharacterized protein
1 - - 0.0
293
Uncharacterized protein
1 - - 0.0
302
Uncharacterized protein
1 - - 0.0
318
Uncharacterized protein
1 - - 0.0
256
Uncharacterized protein
1 - - 0.0
270
Uncharacterized protein
1 - - 0.0
248
Uncharacterized protein
1 - - 0.0
268
Predicted protein
1 - - 0.0
264
Glutamate-gated chloride channel, putative
1 - - 0.0
244
Uncharacterized protein
1 - - 0.0
252
Uncharacterized protein
1 - - 0.0
315
Uncharacterized protein
1 - - 0.0
314
Uncharacterized protein
1 - - 0.0
245
Si:ch211-256e16.4
1 - - 0.0
265
Uncharacterized protein
1 - - 0.0
273
Uncharacterized protein
1 - - 0.0
267
Uncharacterized protein
1 - - 0.0
247
Uncharacterized protein
1 - - 0.0
261
Uncharacterized protein
1 - - 0.0
241
Uncharacterized protein
1 - - 0.0
317
Uncharacterized protein
1 - - 0.0
276
SD09326p
1 - - 0.0
250
Uncharacterized protein
1 - - 0.0
311
Uncharacterized protein
1 - - 0.0
253
Uncharacterized protein
1 - - 0.0
272
Uncharacterized protein
1 - - 0.0
296
Uncharacterized protein
1 - - 0.0
323
Ligand-Gated ion Channel
1 - - 0.0
280
Uncharacterized protein
1 - - 0.0
300
Uncharacterized protein
1 - - 0.0
236
Uncharacterized protein
1 - - 0.0
283
Si:dkey-49c17.4
1 - - 0.0
292
Uncharacterized protein
1 - - 0.0
331
Uncharacterized protein
1 - - 0.0
303
Uncharacterized protein
1 - - 0.0
320
Glycine receptor alpha 4b subunit
1 - - 0.0
CATH-Gene3D is a Global Biodata Core Resource Learn more...