The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Bicelle-embedded integrin alpha(iib) transmembrane segment
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Integrin subunit alpha 7

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P23229 (/IPI) Q13683 (/IPI) Q61738 (/IPI) Q61739 (/IPI) Q63258 (/IPI)
Insulin-like growth factor I binding GO:0031994
Interacting selectively and non-covalently with insulin-like growth factor I.
2 P26007 (/ISS) Q61739 (/ISS)
Neuregulin binding GO:0038132
Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors.
2 P26007 (/ISS) Q61739 (/ISS)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
2 G3V667 (/IPI) Q924W2 (/IPI)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
2 Q61738 (/ISO) Q61739 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 G3V667 (/IDA) Q924W2 (/IDA)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q63258 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q61738 (/ISO)
Insulin-like growth factor I binding GO:0031994
Interacting selectively and non-covalently with insulin-like growth factor I.
1 P23229 (/IDA)
Insulin-like growth factor I binding GO:0031994
Interacting selectively and non-covalently with insulin-like growth factor I.
1 Q61739 (/ISO)
Showing 1 to 10 of 19 entries

There are 59 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
2 Q61738 (/IMP) Q63258 (/IMP)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
2 A8WHQ7 (/IGI) A8WHQ8 (/IGI)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
2 A8WHQ7 (/IMP) A8WHQ8 (/IMP)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
2 G3V667 (/IMP) Q924W2 (/IMP)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
2 P23229 (/TAS) Q13683 (/TAS)
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
2 G3V667 (/IEP) Q924W2 (/IEP)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
2 G3V667 (/IMP) Q924W2 (/IMP)
Cell-substrate junction assembly GO:0007044
The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.
1 P23229 (/TAS)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q63258 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q61738 (/ISO)
Showing 1 to 10 of 59 entries

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 P23229 (/IDA) P26007 (/IDA) Q61739 (/IDA) Q63258 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P23229 (/IDA) Q61739 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P23229 (/TAS) Q13683 (/TAS)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
2 G3V667 (/IDA) Q924W2 (/IDA)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
2 Q61739 (/IDA) Q63258 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q61738 (/ISO) Q61739 (/ISO)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
2 G3V667 (/IDA) Q924W2 (/IDA)
Integrin alpha6-beta4 complex GO:0034676
An integrin complex that comprises one alpha6 subunit and one beta4 subunit.
2 G3V667 (/IDA) Q924W2 (/IDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 Q61739 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q61738 (/IDA)
Showing 1 to 10 of 28 entries
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