The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Single helix bin
".
FunFam 4: FXYD domain-containing ion transport regulator
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q04679 (/IPI) Q58K79 (/IPI) |
|
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
|
2 | Q04646 (/IMP) Q04646 (/IMP) |
|
Transporter activity GO:0005215
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
|
1 | P54710 (/TAS) |
|
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
|
1 | P54710 (/TAS) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
|
2 | Q04646 (/IMP) Q04646 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q04679 (/IMP) |
|
Establishment or maintenance of transmembrane electrochemical gradient GO:0010248
The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore.
|
1 | Q58K79 (/IC) |
|
Monovalent inorganic cation transport GO:0015672
The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.
|
1 | Q04679 (/IDA) |
|
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
|
1 | P54710 (/TAS) |
|
Sodium ion export across plasma membrane GO:0036376
The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
|
1 | Q58K79 (/IDA) |
|
Sodium ion export across plasma membrane GO:0036376
The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
|
1 | P54710 (/ISS) |
|
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
1 | Q58K79 (/IDA) |
|
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
1 | P54710 (/ISS) |
|
Cellular hyperosmotic salinity response GO:0071475
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
|
1 | Q04679 (/IEP) |
|
Regulation of sodium:potassium-exchanging ATPase activity GO:1903406
Any process that modulates the frequency, rate or extent of sodium:potassium-exchanging ATPase activity.
|
1 | Q04679 (/IDA) |
|
Negative regulation of sodium:potassium-exchanging ATPase activity GO:1903407
Any process that stops, prevents or reduces the frequency, rate or extent of sodium:potassium-exchanging ATPase activity.
|
1 | Q04679 (/IMP) |
|
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
|
1 | P54710 (/TAS) |
|
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
|
1 | Q58K79 (/IDA) |
|
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
|
1 | P54710 (/ISS) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
|
2 | Q04679 (/IDA) Q58K79 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | Q04646 (/IDA) Q04646 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q04679 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P54710 (/TAS) |
|
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
|
1 | P54710 (/ISS) |
|
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
|
1 | P54710 (/TAS) |
|
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
1 | Q04679 (/IDA) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | Q04679 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P54710 (/HDA) |
