The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Single helix bin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: FXYD domain-containing ion transport regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O08589 (/IPI) Q3SZX0 (/IPI) Q3SZX0 (/IPI) Q3SZX0 (/IPI)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
4 O00168 (/ISS) O00168 (/ISS) O00168 (/ISS) Q9Z239 (/ISS)
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
3 O00168 (/TAS) O00168 (/TAS) O00168 (/TAS)
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
3 O00168 (/ISS) O00168 (/ISS) O00168 (/ISS)
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
2 P56513 (/IDA) P56513 (/IDA)
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
1 O08589 (/IDA)
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
1 Q9Z239 (/ISO)
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
1 Q9Z239 (/IMP)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 I3LMB3 (/IPI)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 O08589 (/IDA)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 Q9Z239 (/ISO)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of protein glutathionylation GO:0010734
Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.
13 G1TZA0 (/ISS) I3LMB3 (/ISS) O00168 (/ISS) O00168 (/ISS) O00168 (/ISS) O08589 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS) Q9Z239 (/ISS)
(3 more)
Positive regulation of sodium ion export across plasma membrane GO:1903278
Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.
8 I3LMB3 (/ISS) O00168 (/ISS) O00168 (/ISS) O00168 (/ISS) O08589 (/ISS) P56513 (/ISS) P56513 (/ISS) Q9Z239 (/ISS)
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 O00168 (/TAS) O00168 (/TAS) O00168 (/TAS)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
3 O00168 (/TAS) O00168 (/TAS) O00168 (/TAS)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
3 O00168 (/TAS) O00168 (/TAS) O00168 (/TAS)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
3 O00168 (/TAS) O00168 (/TAS) O00168 (/TAS)
Regulation of cardiac muscle cell membrane potential GO:0086036
Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
3 O00168 (/ISS) O00168 (/ISS) O00168 (/ISS)
Positive regulation of sodium ion export across plasma membrane GO:1903278
Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.
3 Q3SZX0 (/IDA) Q3SZX0 (/IDA) Q3SZX0 (/IDA)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
3 O00168 (/TAS) O00168 (/TAS) O00168 (/TAS)
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
3 O00168 (/ISS) O00168 (/ISS) O00168 (/ISS)
Negative regulation of protein glutathionylation GO:0010734
Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage.
2 P56513 (/IDA) P56513 (/IDA)
Regulation of sodium:potassium-exchanging ATPase activity GO:1903406
Any process that modulates the frequency, rate or extent of sodium:potassium-exchanging ATPase activity.
2 P56513 (/IDA) P56513 (/IDA)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 O08589 (/IEP)
Positive regulation of organic acid transport GO:0032892
Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O08589 (/IMP)
Positive regulation of organic acid transport GO:0032892
Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9Z239 (/ISO)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
1 O08589 (/IMP)
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
1 Q9Z239 (/ISO)
Regulation of cardiac muscle cell contraction GO:0086004
Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction.
1 O08589 (/IMP)
Regulation of cardiac muscle cell contraction GO:0086004
Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction.
1 Q9Z239 (/ISO)
Regulation of cardiac muscle cell membrane potential GO:0086036
Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
1 Q9Z239 (/IMP)
Positive regulation of sodium ion export across plasma membrane GO:1903278
Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.
1 Q9Z239 (/IMP)
Positive regulation of inorganic anion transmembrane transport GO:1903797
Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport.
1 O08589 (/IMP)
Positive regulation of inorganic anion transmembrane transport GO:1903797
Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport.
1 Q9Z239 (/ISO)
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
1 Q9Z239 (/IMP)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
14 G1TZA0 (/ISS) I3LMB3 (/ISS) O00168 (/ISS) O00168 (/ISS) O00168 (/ISS) P56513 (/ISS) P56513 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS)
(4 more)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
14 G1TZA0 (/ISS) I3LMB3 (/ISS) O00168 (/ISS) O00168 (/ISS) O00168 (/ISS) P56513 (/ISS) P56513 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS)
(4 more)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
14 G1TZA0 (/ISS) I3LMB3 (/ISS) O00168 (/ISS) O00168 (/ISS) O00168 (/ISS) P56513 (/ISS) P56513 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS)
(4 more)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
10 I3LMB3 (/ISS) O00168 (/ISS) O00168 (/ISS) O00168 (/ISS) P56513 (/ISS) P56513 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS) Q9Z239 (/ISS)
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
8 I3LMB3 (/ISS) O00168 (/ISS) O00168 (/ISS) O00168 (/ISS) O08589 (/ISS) P56513 (/ISS) P56513 (/ISS) Q9Z239 (/ISS)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
8 I3LMB3 (/ISS) O00168 (/ISS) O00168 (/ISS) O00168 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS) Q3SZX0 (/ISS) Q9Z239 (/ISS)
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
4 I3LMB3 (/IDA) Q3SZX0 (/IDA) Q3SZX0 (/IDA) Q3SZX0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O00168 (/NAS) O00168 (/NAS) O00168 (/NAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O00168 (/TAS) O00168 (/TAS) O00168 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 O00168 (/TAS) O00168 (/TAS) O00168 (/TAS)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
3 O08589 (/IDA) P56513 (/IDA) P56513 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
2 I3LMB3 (/IMP) Q9Z239 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O08589 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Z239 (/ISO)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
1 O08589 (/IDA)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
1 Q9Z239 (/ISO)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
1 O08589 (/IDA)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
1 Q9Z239 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 O08589 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q9Z239 (/ISO)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 O08589 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 Q9Z239 (/ISO)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 Q9Z239 (/ISO)
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