The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Importin-alpha, importin-beta-binding domain
".
FunFam 5: Importin subunit alpha
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P52292 (/IPI) P52293 (/IPI) P52293 (/IPI) Q7Z726 (/IPI) |
|
Nuclear localization sequence binding GO:0008139
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
|
2 | P52293 (/ISO) P52293 (/ISO) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
2 | P52293 (/ISO) P52293 (/ISO) |
|
Nuclear import signal receptor activity GO:0061608
Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
|
2 | P52293 (/IDA) P52293 (/IDA) |
|
Repressing transcription factor binding GO:0070491
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.
|
2 | P52293 (/IPI) P52293 (/IPI) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | P52292 (/HDA) |
|
Nuclear localization sequence binding GO:0008139
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
|
1 | P52292 (/IDA) |
|
Histone deacetylase binding GO:0042826
Interacting selectively and non-covalently with the enzyme histone deacetylase.
|
1 | P52292 (/IPI) |
|
RBL family protein binding GO:0061675
Interacting selectively and non-covalently with any member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose.
|
1 | A0A060YJS5 (/IMP) |
There are 16 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Entry of viral genome into host nucleus through nuclear pore complex via importin GO:0075506
Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery.
|
3 | P52292 (/IMP) P52293 (/IMP) P52293 (/IMP) |
|
Positive regulation of viral life cycle GO:1903902
Any process that activates or increases the frequency, rate or extent of viral life cycle.
|
3 | P52292 (/IMP) P52293 (/IMP) P52293 (/IMP) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
2 | P52293 (/IDA) P52293 (/IDA) |
|
NLS-bearing protein import into nucleus GO:0006607
The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
|
2 | P52293 (/ISO) P52293 (/ISO) |
|
Entry of viral genome into host nucleus through nuclear pore complex via importin GO:0075506
Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery.
|
2 | P52293 (/ISO) P52293 (/ISO) |
|
Postsynapse to nucleus signaling pathway GO:0099527
A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
|
2 | P52292 (/IDA) Q9Z0N9 (/IDA) |
|
Postsynapse to nucleus signaling pathway GO:0099527
A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
|
2 | P52293 (/ISO) P52293 (/ISO) |
|
Positive regulation of viral life cycle GO:1903902
Any process that activates or increases the frequency, rate or extent of viral life cycle.
|
2 | P52293 (/ISO) P52293 (/ISO) |
|
Regulation of DNA recombination GO:0000018
Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.
|
1 | P52292 (/TAS) |
|
DNA metabolic process GO:0006259
Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
|
1 | P52292 (/TAS) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
1 | Q6P6T9 (/TAS) |
|
NLS-bearing protein import into nucleus GO:0006607
The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
|
1 | P52292 (/IDA) |
|
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
|
1 | Q6P6T9 (/TAS) |
|
Modulation by virus of host cellular process GO:0019054
The process in which a virus effects a change in the processes and activities of its host organism.
|
1 | P52292 (/TAS) |
|
Regulation of transcription by glucose GO:0046015
Any process involving glucose that modulates the frequency, rate or extent or transcription.
|
1 | Q6P6T9 (/IDA) |
|
Postsynapse to nucleus signaling pathway GO:0099527
A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
|
1 | P52292 (/IMP) |
There are 17 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | J3KS65 (/IDA) J3QLL0 (/IDA) P52292 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | P52292 (/TAS) P52293 (/TAS) P52293 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | J3KS65 (/IDA) J3QLL0 (/IDA) P52292 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P52292 (/TAS) P52293 (/TAS) P52293 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | P52293 (/ISO) P52293 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P52293 (/ISO) P52293 (/ISO) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
2 | P52293 (/IDA) P52293 (/IDA) |
|
Extrinsic component of postsynaptic specialization membrane GO:0098892
The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
2 | P52293 (/ISO) P52293 (/ISO) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
2 | P52293 (/ISO) P52293 (/ISO) |
|
Female germ cell nucleus GO:0001674
The nucleus of the female germ cell, a reproductive cell in females.
|
1 | A0A060YJS5 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | A0A060YJS5 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P52292 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P52292 (/HDA) |
|
NLS-dependent protein nuclear import complex GO:0042564
A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore.
|
1 | A0A060YJS5 (/IDA) |
|
Extrinsic component of postsynaptic specialization membrane GO:0098892
The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
1 | P52292 (/IDA) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | P52292 (/IDA) |
|
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | P52292 (/IMP) |
