The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Importin-alpha, importin-beta-binding domain
".
FunFam 4: Importin subunit alpha
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
18 |
O35344 (/IPI)
O35344 (/IPI)
O35344 (/IPI)
O35344 (/IPI)
O35344 (/IPI)
O35344 (/IPI)
O35344 (/IPI)
O35344 (/IPI)
O35344 (/IPI)
O35344 (/IPI)
(8 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
16 |
O00505 (/IPI)
O00505 (/IPI)
O00505 (/IPI)
O00505 (/IPI)
O00629 (/IPI)
O00629 (/IPI)
O00629 (/IPI)
O00629 (/IPI)
O00629 (/IPI)
O00629 (/IPI)
(6 more) |
|
Nuclear localization sequence binding GO:0008139
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.
|
4 | O00505 (/TAS) O00505 (/TAS) O00505 (/TAS) O00505 (/TAS) |
|
Notch binding GO:0005112
Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
|
3 | O76522 (/IDA) Q9UB78 (/IDA) Q9V455 (/IDA) |
|
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
|
3 | O76522 (/IPI) Q9UB78 (/IPI) Q9V455 (/IPI) |
|
Nuclear import signal receptor activity GO:0061608
Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
|
3 | O35343 (/IDA) O35343 (/IDA) O35343 (/IDA) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
NLS-bearing protein import into nucleus GO:0006607
The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
|
13 |
O00505 (/TAS)
O00505 (/TAS)
O00505 (/TAS)
O00505 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
(3 more) |
|
Modulation by virus of host cellular process GO:0019054
The process in which a virus effects a change in the processes and activities of its host organism.
|
13 |
O00505 (/TAS)
O00505 (/TAS)
O00505 (/TAS)
O00505 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
(3 more) |
|
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
4 | O00505 (/TAS) O00505 (/TAS) O00505 (/TAS) O00505 (/TAS) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
3 | O35343 (/IDA) O35343 (/IDA) O35343 (/IDA) |
|
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
|
3 | O76522 (/IDA) Q9UB78 (/IDA) Q9V455 (/IDA) |
|
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
3 | O35343 (/IMP) O35343 (/IMP) O35343 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
13 |
O00505 (/TAS)
O00505 (/TAS)
O00505 (/TAS)
O00505 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
(3 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
13 |
O00505 (/TAS)
O00505 (/TAS)
O00505 (/TAS)
O00505 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
O00629 (/TAS)
(3 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
12 |
O00629 (/IDA)
O00629 (/IDA)
O00629 (/IDA)
O00629 (/IDA)
O00629 (/IDA)
O00629 (/IDA)
O00629 (/IDA)
O00629 (/IDA)
O00629 (/IDA)
O35343 (/IDA)
(2 more) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
9 | O00629 (/IDA) O00629 (/IDA) O00629 (/IDA) O00629 (/IDA) O00629 (/IDA) O00629 (/IDA) O00629 (/IDA) O00629 (/IDA) O00629 (/IDA) |
|
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
|
4 | O00505 (/TAS) O00505 (/TAS) O00505 (/TAS) O00505 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O35343 (/ISO) O35343 (/ISO) O35343 (/ISO) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
3 | O35343 (/ISO) O35343 (/ISO) O35343 (/ISO) |
