The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Importin-alpha, importin-beta-binding domain
".
FunFam 3: Importin subunit alpha
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
O14063 (/IPI)
O94374 (/IPI)
Q02821 (/IPI)
Q02821 (/IPI)
Q02821 (/IPI)
Q02821 (/IPI)
Q02821 (/IPI)
Q02821 (/IPI)
Q02821 (/IPI)
Q02821 (/IPI)
(1 more) |
Nuclear import signal receptor activity GO:0061608
Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
|
11 |
O14063 (/IDA)
O94374 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
(1 more) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
9 | Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) |
Disordered domain specific binding GO:0097718
Interacting selectively and non-covalently with a disordered domain of a protein.
|
9 | Q02821 (/IPI) Q02821 (/IPI) Q02821 (/IPI) Q02821 (/IPI) Q02821 (/IPI) Q02821 (/IPI) Q02821 (/IPI) Q02821 (/IPI) Q02821 (/IPI) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
2 | O14063 (/NAS) O94374 (/NAS) |
Nuclear import signal receptor activity GO:0061608
Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
|
2 | O14063 (/IMP) O94374 (/IMP) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
NLS-bearing protein import into nucleus GO:0006607
The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
|
10 | O94374 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) |
Protein targeting to membrane GO:0006612
The process of directing proteins towards a membrane, usually using signals contained within the protein.
|
9 | Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) |
Proteasome localization GO:0031144
Any process in which the proteasome is transported to, or maintained in, a specific location.
|
9 | Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) |
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
2 | O14063 (/IDA) O94374 (/IDA) |
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
2 | G5EB89 (/IMP) O14063 (/IMP) |
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
12 |
G5EB89 (/IDA)
O14063 (/IDA)
O94374 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
(2 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
11 |
G5EB89 (/IDA)
O94374 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
Q02821 (/IDA)
(1 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
10 | O94374 (/HDA) Q02821 (/HDA) Q02821 (/HDA) Q02821 (/HDA) Q02821 (/HDA) Q02821 (/HDA) Q02821 (/HDA) Q02821 (/HDA) Q02821 (/HDA) Q02821 (/HDA) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
9 | Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) |
NLS-dependent protein nuclear import complex GO:0042564
A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore.
|
9 | Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) Q02821 (/IDA) |
NLS-dependent protein nuclear import complex GO:0042564
A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore.
|
9 | Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) Q02821 (/IMP) |
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
2 | O14063 (/HDA) O94374 (/HDA) |
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
|
2 | O14063 (/IDA) O94374 (/IDA) |
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
|
1 | O94374 (/IDA) |
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
|
1 | O14063 (/NAS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | O94374 (/IDA) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | O94374 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O14063 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O94374 (/HDA) |
Mitotic spindle midzone GO:1990023
The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner.
|
1 | O94374 (/IDA) |