CATH Superfamily 1.20.5.5200
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 1: Stimulator of interferon genes protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 18 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
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8 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q3TBT3 (/ISS) Q3TBT3 (/ISS) |
Cyclic-GMP-AMP binding GO:0061507
Interacting selectively and non-covalently with cyclic-GMP-AMP (cGAMP) cyclic nucleotide.
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7 | A7SLZ2 (/IDA) A8E5V9 (/IDA) E1C7U0 (/IDA) F1M391 (/IDA) Q3TBT3 (/IDA) Q3TBT3 (/IDA) Q86WV6 (/IDA) |
Cyclic-GMP-AMP binding GO:0061507
Interacting selectively and non-covalently with cyclic-GMP-AMP (cGAMP) cyclic nucleotide.
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7 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q86WV6 (/ISS) |
Cyclic-di-GMP binding GO:0035438
Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
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6 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) |
Cyclic-di-GMP binding GO:0035438
Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
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4 | A7SLZ2 (/IDA) Q3TBT3 (/IDA) Q3TBT3 (/IDA) Q86WV6 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
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3 | Q3TBT3 (/IPI) Q3TBT3 (/IPI) Q86WV6 (/IPI) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
2 | Q3TBT3 (/ISO) Q3TBT3 (/ISO) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
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2 | Q3TBT3 (/ISO) Q3TBT3 (/ISO) |
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
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2 | Q3TBT3 (/IPI) Q3TBT3 (/IPI) |
Cyclic-di-GMP binding GO:0035438
Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate.
|
2 | Q3TBT3 (/ISO) Q3TBT3 (/ISO) |
Showing 1 to 10 of 18 entries
There are 55 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Interferon-beta production GO:0032608
The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
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9 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) F1M391 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q3TBT3 (/ISS) Q3TBT3 (/ISS) |
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
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9 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) F1M391 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q3TBT3 (/ISS) Q3TBT3 (/ISS) |
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
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9 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) F1M391 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q3TBT3 (/ISS) Q3TBT3 (/ISS) |
Reticulophagy GO:0061709
The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.
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8 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) F1M391 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q86WV6 (/ISS) |
Autophagosome assembly GO:0000045
The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
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7 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) F1M391 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) |
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
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6 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) |
Positive regulation of macroautophagy GO:0016239
Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
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6 | B8XX90 (/ISS) E1C7U0 (/ISS) F1M391 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) |
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
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6 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) |
Positive regulation of macroautophagy GO:0016239
Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
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4 | A7SLZ2 (/IDA) A8E5V9 (/IDA) E7F4N7 (/IDA) Q86WV6 (/IDA) |
Positive regulation of type I interferon production GO:0032481
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
4 | F1M391 (/IDA) Q3TBT3 (/IDA) Q3TBT3 (/IDA) Q86WV6 (/IDA) |
Showing 1 to 10 of 55 entries
There are 22 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
8 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q3TBT3 (/ISS) Q3TBT3 (/ISS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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7 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) F1M391 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
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7 | A8E5V9 (/ISS) B8XX90 (/ISS) E1C7U0 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q2KI99 (/ISS) Q86WV6 (/ISS) |
Autophagosome GO:0005776
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
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3 | Q3TBT3 (/IDA) Q3TBT3 (/IDA) Q86WV6 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
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3 | E7F4N7 (/IDA) Q3TBT3 (/IDA) Q3TBT3 (/IDA) |
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
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3 | Q3TBT3 (/IDA) Q3TBT3 (/IDA) Q86WV6 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q3TBT3 (/IDA) Q3TBT3 (/IDA) |
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
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2 | Q3TBT3 (/ISO) Q3TBT3 (/ISO) |
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
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2 | Q3TBT3 (/ISO) Q3TBT3 (/ISO) |
Autophagosome GO:0005776
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
|
2 | Q3TBT3 (/ISO) Q3TBT3 (/ISO) |
Showing 1 to 10 of 22 entries