The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Bone marrow stromal antigen 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
5 Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS) Q8R2Q8 (/ISS) Q8R2Q8 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q10589 (/IPI) Q10589 (/IPI) Q811A2 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q10589 (/HDA) Q10589 (/HDA)
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2 Q10589 (/IDA) Q10589 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q10589 (/IPI) Q10589 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q10589 (/IPI) Q10589 (/IPI)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
6 Q10589 (/ISS) Q10589 (/ISS) Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q8R2Q8 (/ISS) Q8R2Q8 (/ISS)
Negative regulation of plasmacytoid dendritic cell cytokine production GO:0002737
Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.
5 Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS) Q8R2Q8 (/ISS) Q8R2Q8 (/ISS)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
5 Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS) Q8R2Q8 (/ISS) Q8R2Q8 (/ISS)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
5 Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS) Q8R2Q8 (/ISS) Q8R2Q8 (/ISS)
Response to interferon-gamma GO:0034341
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
5 Q10589 (/ISS) Q10589 (/ISS) Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS)
Response to interferon-alpha GO:0035455
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
5 Q10589 (/ISS) Q10589 (/ISS) Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS)
Response to interferon-beta GO:0035456
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
5 Q10589 (/ISS) Q10589 (/ISS) Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
4 Q10589 (/IDA) Q10589 (/IDA) Q8R2Q8 (/IDA) Q8R2Q8 (/IDA)
Negative regulation of intracellular transport of viral material GO:1901253
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material.
4 Q10589 (/IDA) Q10589 (/IDA) Q8R2Q8 (/IDA) Q8R2Q8 (/IDA)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
3 Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
3 Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
3 Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS)
Negative regulation of intracellular transport of viral material GO:1901253
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material.
3 Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS)
Negative regulation of plasmacytoid dendritic cell cytokine production GO:0002737
Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.
2 Q10589 (/IDA) Q10589 (/IDA)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
2 Q10589 (/IDA) Q10589 (/IDA)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
2 Q10589 (/IDA) Q10589 (/IDA)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
2 Q8R2Q8 (/ISO) Q8R2Q8 (/ISO)
Response to interferon-gamma GO:0034341
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
2 Q8R2Q8 (/IDA) Q8R2Q8 (/IDA)
Response to interferon-alpha GO:0035455
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
2 Q8R2Q8 (/IDA) Q8R2Q8 (/IDA)
Response to interferon-beta GO:0035456
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
2 Q8R2Q8 (/IDA) Q8R2Q8 (/IDA)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
2 Q10589 (/HMP) Q10589 (/HMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
2 Q10589 (/TAS) Q10589 (/TAS)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
2 Q10589 (/IDA) Q10589 (/IDA)
Negative regulation of viral genome replication GO:0045071
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.
2 Q8R2Q8 (/IMP) Q8R2Q8 (/IMP)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
2 Q10589 (/IDA) Q10589 (/IDA)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
2 Q8R2Q8 (/IMP) Q8R2Q8 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 Q10589 (/IDA) Q10589 (/IDA)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2 Q10589 (/TAS) Q10589 (/TAS)
Positive regulation of leukocyte proliferation GO:0070665
Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.
2 Q10589 (/TAS) Q10589 (/TAS)
Negative regulation of intracellular transport of viral material GO:1901253
Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material.
2 Q8R2Q8 (/IMP) Q8R2Q8 (/IMP)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q811A2 (/IMP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
6 Q10589 (/ISS) Q10589 (/ISS) Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q8R2Q8 (/ISS) Q8R2Q8 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 Q6WRU0 (/ISS) Q6WRU0 (/ISS) Q811A2 (/ISS) Q8R2Q8 (/ISS) Q8R2Q8 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 A0A024R7H5 (/IDA) A0A024R7H5 (/IDA) Q10589 (/IDA) Q10589 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 A0A024R7H5 (/IDA) A0A024R7H5 (/IDA) Q10589 (/IDA) Q10589 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 A0A024R7H5 (/IDA) A0A024R7H5 (/IDA) Q10589 (/IDA) Q10589 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 Q10589 (/ISS) Q10589 (/ISS) Q6WRU0 (/ISS) Q6WRU0 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 Q811A2 (/IDA) Q8R2Q8 (/IDA) Q8R2Q8 (/IDA)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
2 Q10589 (/IMP) Q10589 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q10589 (/TAS) Q10589 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q10589 (/IMP) Q10589 (/IMP)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q8R2Q8 (/ISO) Q8R2Q8 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q10589 (/HDA) Q10589 (/HDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q8R2Q8 (/ISO) Q8R2Q8 (/ISO)
Azurophil granule membrane GO:0035577
The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
2 Q10589 (/TAS) Q10589 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q10589 (/HDA) Q10589 (/HDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q811A2 (/IDA)
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