The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: hepatic leukemia factor isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
48 M9PBV3 (/IDA) M9PEP3 (/IDA) M9PEX4 (/IDA) P16443 (/IDA) P41224 (/IDA) Q10586 (/IDA) Q10586 (/IDA) Q16534 (/IDA) Q16534 (/IDA) Q16534 (/IDA)
(38 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
28 Q10586 (/ISA) Q10586 (/ISA) Q10587 (/ISA) Q10587 (/ISA) Q10587 (/ISA) Q10587 (/ISA) Q10587 (/ISA) Q10587 (/ISA) Q10587 (/ISA) Q10587 (/ISA)
(18 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
28 Q10586 (/ISM) Q10586 (/ISM) Q10587 (/ISM) Q10587 (/ISM) Q10587 (/ISM) Q10587 (/ISM) Q10587 (/ISM) Q10587 (/ISM) Q10587 (/ISM) Q10587 (/ISM)
(18 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
27 M9PBV3 (/IDA) M9PEP3 (/IDA) M9PEX4 (/IDA) P41224 (/IDA) Q24217 (/IDA) Q24217 (/IDA) Q24217 (/IDA) Q24217 (/IDA) Q5U8V5 (/IDA) Q5U8V5 (/IDA)
(17 more)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
18 Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP)
(8 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
18 Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS)
(8 more)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
18 Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS)
(8 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
18 Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP) Q16534 (/IMP)
(8 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
10 Q10586 (/NAS) Q10586 (/NAS) Q10587 (/NAS) Q10587 (/NAS) Q10587 (/NAS) Q10587 (/NAS) Q10587 (/NAS) Q10587 (/NAS) Q10587 (/NAS) Q10587 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 Q10587 (/IPI) Q10587 (/IPI) Q10587 (/IPI) Q10587 (/IPI) Q10587 (/IPI) Q10587 (/IPI) Q10587 (/IPI) Q10587 (/IPI)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 Q24217 (/IDA) Q24217 (/IDA) Q24217 (/IDA) Q24217 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 Q60925 (/ISO) Q8BW74 (/ISO) Q9JLC6 (/ISO)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2 Q10586 (/IDA) Q10586 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q8BW74 (/ISO) Q9JLC6 (/ISO)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 Q60925 (/ISO)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P41224 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q9JLC6 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 Q92172 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 Q9JLC6 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P41224 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9JLC6 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P41224 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9JLC6 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
27 M9PBV3 (/TAS) M9PEP3 (/TAS) M9PEX4 (/TAS) Q24217 (/TAS) Q24217 (/TAS) Q24217 (/TAS) Q24217 (/TAS) Q5U8V5 (/TAS) Q5U8V5 (/TAS) Q5U8V5 (/TAS)
(17 more)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
26 M9PBV3 (/IDA) M9PEP3 (/IDA) M9PEX4 (/IDA) Q24217 (/IDA) Q24217 (/IDA) Q24217 (/IDA) Q24217 (/IDA) Q5U8V5 (/IDA) Q5U8V5 (/IDA) Q5U8V5 (/IDA)
(16 more)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
26 M9PBV3 (/IGI) M9PEP3 (/IGI) M9PEX4 (/IGI) Q24217 (/IGI) Q24217 (/IGI) Q24217 (/IGI) Q24217 (/IGI) Q5U8V5 (/IGI) Q5U8V5 (/IGI) Q5U8V5 (/IGI)
(16 more)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
26 M9PBV3 (/IMP) M9PEP3 (/IMP) M9PEX4 (/IMP) Q24217 (/IMP) Q24217 (/IMP) Q24217 (/IMP) Q24217 (/IMP) Q5U8V5 (/IMP) Q5U8V5 (/IMP) Q5U8V5 (/IMP)
(16 more)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
26 M9PBV3 (/IMP) M9PEP3 (/IMP) M9PEX4 (/IMP) Q24217 (/IMP) Q24217 (/IMP) Q24217 (/IMP) Q24217 (/IMP) Q5U8V5 (/IMP) Q5U8V5 (/IMP) Q5U8V5 (/IMP)
(16 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
24 P16443 (/IDA) P41224 (/IDA) Q10586 (/IDA) Q10586 (/IDA) Q16534 (/IDA) Q16534 (/IDA) Q16534 (/IDA) Q16534 (/IDA) Q16534 (/IDA) Q16534 (/IDA)
(14 more)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
18 Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS)
(8 more)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
18 Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS)
(8 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
10 Q10586 (/TAS) Q10586 (/TAS) Q10587 (/TAS) Q10587 (/TAS) Q10587 (/TAS) Q10587 (/TAS) Q10587 (/TAS) Q10587 (/TAS) Q10587 (/TAS) Q10587 (/TAS)
Cellular response to light stimulus GO:0071482
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
6 E2E3F0 (/IMP) F1QEE6 (/IMP) O57673 (/IMP) Q502I5 (/IMP) Q6DC08 (/IMP) Q9W722 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 Q24217 (/IDA) Q24217 (/IDA) Q24217 (/IDA) Q24217 (/IDA) Q92172 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 O57673 (/IMP) Q6DC08 (/IMP) Q9W722 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 Q60925 (/ISO) Q8BW74 (/ISO) Q9JLC6 (/ISO)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 P16443 (/IEP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q60925 (/TAS)
Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
1 Q8BW74 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
49 I3L4R4 (/IDA) I3L4R4 (/IDA) I3L4R4 (/IDA) M9PBV3 (/IDA) M9PEP3 (/IDA) M9PEX4 (/IDA) P16443 (/IDA) P41224 (/IDA) Q16534 (/IDA) Q16534 (/IDA)
(39 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
18 Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS) Q16534 (/TAS)
(8 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q24217 (/IC) Q24217 (/IC) Q24217 (/IC) Q24217 (/IC) Q92172 (/IC)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 Q24217 (/TAS) Q24217 (/TAS) Q24217 (/TAS) Q24217 (/TAS) Q60925 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q60925 (/ISO) Q8BW74 (/ISO) Q9JLC6 (/ISO)
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