The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Cyclic AMP-dependent transcription factor ATF-2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 51 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
22 P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
21 P15336 (/NAS) P15336 (/NAS) P15336 (/NAS) P15336 (/NAS) P15336 (/NAS) P15336 (/NAS) P15336 (/NAS) P15336 (/NAS) P15336 (/NAS) P15336 (/NAS)
(11 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
20 P15336 (/ISA) P15336 (/ISA) P15336 (/ISA) P15336 (/ISA) P15336 (/ISA) P15336 (/ISA) P15336 (/ISA) P15336 (/ISA) P15336 (/ISA) P15336 (/ISA)
(10 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
20 P15336 (/ISM) P15336 (/ISM) P15336 (/ISM) P15336 (/ISM) P15336 (/ISM) P15336 (/ISM) P15336 (/ISM) P15336 (/ISM) P15336 (/ISM) P15336 (/ISM)
(10 more)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
19 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(9 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
17 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(7 more)
CAMP response element binding GO:0035497
Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.
17 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(7 more)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
16 P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP)
(6 more)
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
16 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(6 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
16 P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC)
(6 more)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
16 P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI)
(6 more)
Enhancer sequence-specific DNA binding GO:0001158
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
16 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(6 more)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
16 P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC) P15336 (/IC)
(6 more)
Histone acetyltransferase activity GO:0004402
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
16 P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS)
(6 more)
CAMP response element binding protein binding GO:0008140
Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein).
16 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(6 more)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
16 P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI) P15336 (/IPI)
(6 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
3 P17544 (/NAS) P17544 (/NAS) P17544 (/NAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
3 P17544 (/IDA) P17544 (/IDA) P17544 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
3 P16951 (/ISO) Q8R0S1 (/ISO) Q8R0S1 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
3 P17544 (/IPI) P17544 (/IPI) P17544 (/IPI)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
3 P17544 (/IDA) P17544 (/IDA) P17544 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
2 Q8R0S1 (/ISO) Q8R0S1 (/ISO)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 Q8R0S1 (/ISO) Q8R0S1 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 P16951 (/ISO) Q8K1L0 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 Q8R0S1 (/ISO) Q8R0S1 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 Q00969 (/IDA) Q09926 (/IDA)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
2 Q8R0S1 (/ISO) Q8R0S1 (/ISO)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 P16951 (/ISO)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q09926 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P78962 (/NAS)
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
1 P16951 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q09926 (/IMP)
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
1 P16951 (/ISO)
Enhancer sequence-specific DNA binding GO:0001158
Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.
1 P16951 (/ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q09926 (/IMP)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P16951 (/ISO)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P16951 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 P16951 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 Q09926 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q8K1L0 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q09926 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q00969 (/IPI)
CAMP response element binding protein binding GO:0008140
Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein).
1 P16951 (/ISO)
Recombination hotspot binding GO:0010844
Interacting selectively and non-covalently with a region in a genome which promotes recombination.
1 Q09926 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P16951 (/ISO)
CAMP response element binding GO:0035497
Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.
1 P16951 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 F1RZI1 (/IC)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 P16951 (/IMP)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 P16951 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q00969 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P16951 (/ISO)

There are 59 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
17 P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP)
(7 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
17 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(7 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
16 P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP)
(6 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
16 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(6 more)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
16 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(6 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
16 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(6 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
16 P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP)
(6 more)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
16 P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP)
(6 more)
Intra-S DNA damage checkpoint GO:0031573
A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
16 P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP)
(6 more)
Regulation of DNA-binding transcription factor activity GO:0051090
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
16 P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS)
(6 more)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
16 P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP)
(6 more)
Positive regulation of cardiac muscle myoblast proliferation GO:0110024
Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation.
16 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(6 more)
Positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110
Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process.
16 P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP) P15336 (/IMP)
(6 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 P16951 (/ISO) Q8R0S1 (/ISO) Q8R0S1 (/ISO)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 P17544 (/IDA) P17544 (/IDA) P17544 (/IDA)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 P16951 (/ISO) Q8R0S1 (/ISO) Q8R0S1 (/ISO)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 P16951 (/ISS) Q00969 (/ISS)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
2 P16951 (/ISS) Q00969 (/ISS)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
2 P16951 (/ISS) Q00969 (/ISS)
Intra-S DNA damage checkpoint GO:0031573
A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
2 P16951 (/ISS) Q00969 (/ISS)
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
2 P16951 (/IGI) Q8K1L0 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P16951 (/IGI) Q8K1L0 (/IGI)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
2 P16951 (/ISS) Q00969 (/ISS)
Adipose tissue development GO:0060612
The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.
2 P16951 (/IGI) Q8K1L0 (/IGI)
Positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110
Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process.
2 P16951 (/ISS) Q00969 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q00969 (/IMP)
Outflow tract morphogenesis GO:0003151
The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
1 P16951 (/IMP)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 Q09926 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q09926 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P16951 (/ISO)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 Q02930 (/TAS)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
1 P16951 (/ISO)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 P16951 (/ISO)
Reciprocal meiotic recombination GO:0007131
The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.
1 Q09926 (/IMP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
1 Q00969 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P16951 (/ISO)
Regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle GO:0010672
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle.
1 P78962 (/IMP)
Regulation of chromatin assembly GO:0010847
Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus.
1 Q09926 (/IMP)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
1 P16951 (/ISO)
Intra-S DNA damage checkpoint GO:0031573
A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
1 P16951 (/ISO)
Positive regulation of transforming growth factor beta2 production GO:0032915
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2.
1 P16951 (/IMP)
Regulation of histone acetylation GO:0035065
Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein.
1 Q09926 (/IMP)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
1 Q00969 (/IMP)
Positive regulation of neuron apoptotic process GO:0043525
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.
1 P16951 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q02930 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 F1RZI1 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8K1L0 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q8K1L0 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P16951 (/ISO)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
1 Q00969 (/IMP)
Negative regulation of epithelial cell proliferation GO:0050680
Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
1 P16951 (/ISO)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 P16951 (/ISO)
Amelogenesis GO:0097186
The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage.
1 Q00969 (/IDA)
Amelogenesis GO:0097186
The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage.
1 P16951 (/ISO)
Positive regulation of cardiac muscle myoblast proliferation GO:0110024
Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation.
1 P16951 (/ISO)
Negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway GO:0110034
Any process that stops, prevents, or reduces the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway.
1 Q09926 (/IMP)
Positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110
Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process.
1 P16951 (/ISO)
Positive regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation GO:1903694
Any process that activates or increases the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation.
1 Q09926 (/IMP)
Positive regulation of transcription from RNA polymerase II promoter in response to maltose GO:1904765
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a maltose stimulus.
1 Q09926 (/IMP)

There are 26 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
35 B8ZZU6 (/IDA) B8ZZU6 (/IDA) B8ZZU6 (/IDA) B8ZZU6 (/IDA) B8ZZU6 (/IDA) B8ZZU6 (/IDA) B8ZZU6 (/IDA) B8ZZU6 (/IDA) B8ZZU6 (/IDA) B8ZZU6 (/IDA)
(25 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
19 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(9 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
16 P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS) P15336 (/TAS)
(6 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
16 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(6 more)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
16 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(6 more)
Site of double-strand break GO:0035861
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
16 P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA) P15336 (/IDA)
(6 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P17544 (/NAS) P17544 (/NAS) P17544 (/NAS)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
3 P17544 (/IDA) P17544 (/IDA) P17544 (/IDA)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
3 Q5R9C9 (/ISS) Q8R0S1 (/ISS) Q8R0S1 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P78962 (/HDA) Q09926 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 F1RZI1 (/IC) Q02930 (/IC)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P16951 (/ISS) Q00969 (/ISS)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
2 P16951 (/ISS) Q00969 (/ISS)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
2 Q8R0S1 (/ISO) Q8R0S1 (/ISO)
Site of double-strand break GO:0035861
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
2 P16951 (/ISS) Q00969 (/ISS)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q09926 (/NAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P16951 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P16951 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P16951 (/ISO)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 P16951 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P16951 (/IDA)
Site of double-strand break GO:0035861
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
1 P16951 (/IMP)
Site of double-strand break GO:0035861
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
1 P16951 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q02930 (/HDA)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
1 Q09926 (/HDA)
Atf1-pcr1 complex GO:1990243
A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE).
1 Q09926 (/IDA)
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