The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Tumor necrosis factor alpha-induced protein 8-like
".
FunFam 1: Tumor necrosis factor alpha-induced protein 8-like...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
13 |
O95379 (/IPI)
O95379 (/IPI)
O95379 (/IPI)
O95379 (/IPI)
Q55BQ2 (/IPI)
Q6P589 (/IPI)
Q8K288 (/IPI)
Q8WVP5 (/IPI)
Q8WVP5 (/IPI)
Q8WVP5 (/IPI)
(3 more) |
|
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
|
11 |
Q28I19 (/ISS)
Q28I19 (/ISS)
Q28ZG0 (/ISS)
Q28ZG0 (/ISS)
Q5RF18 (/ISS)
Q5ZI78 (/ISS)
Q6GQ44 (/ISS)
Q6GQ44 (/ISS)
Q7KVH9 (/ISS)
Q7KVH9 (/ISS)
(1 more) |
|
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
|
4 | O95379 (/IMP) O95379 (/IMP) O95379 (/IMP) O95379 (/IMP) |
|
Phosphatidylinositol transfer activity GO:0008526
Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
|
1 | Q3TBL6 (/IMP) |
|
Phosphatidylinositol transfer activity GO:0008526
Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle.
|
1 | Q5GJ75 (/ISS) |
|
G-protein beta/gamma-subunit complex binding GO:0031683
Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits.
|
1 | Q55BQ2 (/IDA) |
|
Heterotrimeric G-protein binding GO:0032795
Interacting selectively and non-covalently with a heterotrimeric G-protein.
|
1 | Q55BQ2 (/IDA) |
|
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
|
1 | Q3TBL6 (/IDA) |
|
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
|
1 | Q5GJ75 (/ISS) |
|
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
|
1 | Q921Z5 (/ISO) |
|
GTPase binding GO:0051020
Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
|
1 | Q55BQ2 (/IPI) |
There are 29 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
11 |
Q28I19 (/ISS)
Q28I19 (/ISS)
Q28ZG0 (/ISS)
Q28ZG0 (/ISS)
Q5RF18 (/ISS)
Q5ZI78 (/ISS)
Q6GQ44 (/ISS)
Q6GQ44 (/ISS)
Q7KVH9 (/ISS)
Q7KVH9 (/ISS)
(1 more) |
|
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
|
8 | A5PK29 (/ISS) M0R7K3 (/ISS) Q5ZJU8 (/ISS) Q7SZE8 (/ISS) Q8WVP5 (/ISS) Q8WVP5 (/ISS) Q8WVP5 (/ISS) Q8WVP5 (/ISS) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
4 | O95379 (/IMP) O95379 (/IMP) O95379 (/IMP) O95379 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
4 | O95379 (/TAS) O95379 (/TAS) O95379 (/TAS) O95379 (/TAS) |
|
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
|
2 | Q7KVH9 (/IMP) Q7KVH9 (/IMP) |
|
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
2 | Q7KVH9 (/IMP) Q7KVH9 (/IMP) |
|
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
2 | Q7KVH9 (/IMP) Q7KVH9 (/IMP) |
|
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
2 | Q9D8Y7 (/IMP) Q9D8Y7 (/IMP) |
|
Negative regulation of T cell activation GO:0050868
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
|
2 | Q9D8Y7 (/IMP) Q9D8Y7 (/IMP) |
|
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
|
2 | Q7KVH9 (/IMP) Q7KVH9 (/IMP) |
|
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
|
1 | Q5GJ75 (/TAS) |
|
Phospholipid transport GO:0015914
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
|
1 | Q3TBL6 (/IDA) |
|
Phospholipid transport GO:0015914
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
|
1 | Q5GJ75 (/ISS) |
|
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
1 | Q3TBL6 (/IDA) |
|
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
1 | Q5GJ75 (/ISS) |
|
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
|
1 | Q8K288 (/IDA) |
|
Interleukin-1 beta production GO:0032611
The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
1 | Q921Z5 (/IMP) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q921Z5 (/ISO) |
|
Chemotaxis to cAMP GO:0043327
The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP.
|
1 | Q55BQ2 (/IMP) |
|
Positive regulation of phosphatidylinositol 3-kinase activity GO:0043552
Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
|
1 | Q3TBL6 (/IDA) |
|
Positive regulation of phosphatidylinositol 3-kinase activity GO:0043552
Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
|
1 | Q5GJ75 (/ISS) |
|
Inositol lipid-mediated signaling GO:0048017
A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids.
|
1 | Q3TBL6 (/IDA) |
|
Inositol lipid-mediated signaling GO:0048017
A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids.
|
1 | Q5GJ75 (/ISS) |
|
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
|
1 | Q921Z5 (/IMP) |
|
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | Q3TBL6 (/IDA) |
|
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | Q5GJ75 (/ISS) |
|
Establishment of protein localization to plasma membrane GO:0061951
The directed movement of a protein to a specific location in a plasma membrane.
|
1 | Q55BQ2 (/IMP) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q3TBL6 (/IDA) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q5GJ75 (/ISS) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
19 |
A5PK29 (/ISS)
M0R7K3 (/ISS)
Q28I19 (/ISS)
Q28I19 (/ISS)
Q28ZG0 (/ISS)
Q28ZG0 (/ISS)
Q5RF18 (/ISS)
Q5ZI78 (/ISS)
Q5ZJU8 (/ISS)
Q6GQ44 (/ISS)
(9 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
12 |
A0A1B0GTK8 (/IDA)
A0A1B0GTK8 (/IDA)
A0A1B0GTK8 (/IDA)
D6RCM8 (/IDA)
D6RCM8 (/IDA)
D6RCM8 (/IDA)
D6RCM8 (/IDA)
O95379 (/IDA)
O95379 (/IDA)
O95379 (/IDA)
(2 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
11 |
O95379 (/IDA)
O95379 (/IDA)
O95379 (/IDA)
O95379 (/IDA)
Q3TBL6 (/IDA)
Q5GJ75 (/IDA)
Q7KVH9 (/IDA)
Q7KVH9 (/IDA)
Q8K288 (/IDA)
Q9D8Y7 (/IDA)
(1 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | A0A1B0GTK8 (/IDA) A0A1B0GTK8 (/IDA) A0A1B0GTK8 (/IDA) Q55BQ2 (/IDA) Q5GJ75 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q3TBL6 (/ISO) Q921Z5 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q3TBL6 (/ISO) Q921Z5 (/ISO) |
|
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
|
2 | Q7KVH9 (/IDA) Q7KVH9 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q3TBL6 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q5GJ75 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q3TBL6 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q5GJ75 (/ISS) |
