The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
PWI domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: U4/U6 small nuclear ribonucleoprotein Prp3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
33 A0A0G2JTI7 (/IPI) D3ZI99 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI)
(23 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
31 O43395 (/HDA) O43395 (/HDA) O43395 (/HDA) O43395 (/HDA) O43395 (/HDA) O43395 (/HDA) O43395 (/HDA) O43395 (/HDA) O43395 (/HDA) O43395 (/HDA)
(21 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
31 O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI) O43395 (/IPI)
(21 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q922U1 (/ISO)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Spliceosomal tri-snRNP complex assembly GO:0000244
The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex.
31 O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA)
(21 more)
RNA splicing, via transesterification reactions GO:0000375
Splicing of RNA via a series of two transesterification reactions.
31 O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS)
(21 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
31 O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA)
(21 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
31 O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS)
(21 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
31 O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS)
(21 more)
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
31 O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS)
(21 more)
RNA splicing GO:0008380
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
31 O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS)
(21 more)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
6 A0A0R4IL44 (/IMP) A4QP06 (/IMP) E9QJ65 (/IMP) Q568C8 (/IMP) Q6DRF8 (/IMP) Q6TNT6 (/IMP)
Spliceosomal tri-snRNP complex assembly GO:0000244
The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex.
4 Q2KIA6 (/ISS) Q5R5F1 (/ISS) Q5ZJ85 (/ISS) Q922U1 (/ISS)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
4 Q2KIA6 (/ISS) Q5R5F1 (/ISS) Q5ZJ85 (/ISS) Q922U1 (/ISS)
Spliceosomal tri-snRNP complex assembly GO:0000244
The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex.
1 Q922U1 (/ISO)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
1 Q922U1 (/ISO)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
33 A0A0G2JTI7 (/IDA) D3ZI99 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA)
(23 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
31 O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS)
(21 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
31 O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA)
(21 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
31 O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS) O43395 (/TAS)
(21 more)
Spliceosomal complex GO:0005681
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
31 O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS) O43395 (/NAS)
(21 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
31 O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA)
(21 more)
Cajal body GO:0015030
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
31 O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA)
(21 more)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
31 O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA)
(21 more)
U4/U6 x U5 tri-snRNP complex GO:0046540
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.
31 O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA)
(21 more)
U2-type precatalytic spliceosome GO:0071005
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
31 O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA) O43395 (/IDA)
(21 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q2KIA6 (/ISS) Q5R5F1 (/ISS) Q5ZJ85 (/ISS) Q922U1 (/ISS)
U4/U6 x U5 tri-snRNP complex GO:0046540
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.
4 Q2KIA6 (/ISS) Q5R5F1 (/ISS) Q5ZJ85 (/ISS) Q922U1 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 A0A0G2JTI7 (/IDA) D3ZI99 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q922U1 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q922U1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q922U1 (/ISO)
Cajal body GO:0015030
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
1 Q922U1 (/ISO)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q922U1 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q922U1 (/ISO)
U4/U6 x U5 tri-snRNP complex GO:0046540
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins.
1 Q922U1 (/ISO)
U2-type precatalytic spliceosome GO:0071005
A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
1 Q922U1 (/ISO)
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