The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1F-box/LRR-repeat protein 3 isoform X1Transport inhibitor response 1F-box only protein 4 (Predicted)Coronatine-insensitive protein 1F-box and WD repeat domain-containing 7SC:2F-box/WD repeat-containing protein 11 isoform X2Cell division control protein 4F-box only protein 44F-box only protein 11F-box/WD repeat-containing protein 7 isoform X1F-box/LRR-repeat protein 5 isoform X1F-box only protein 6F-box only protein 10F-box only protein 7F-box DNA helicase 1F-box only protein 9F-box/LRR-repeat protein 20 isoform X1F-box only protein 8F-box/WD repeat-containing protein 2 isoform X2E3 ubiquitin ligase complex SCF subunit sconBF-box only protein 32F-box/LRR-repeat protein 7 isoform X2F-box only protein 3Adagio protein 1F-box protein FBW2F-box/LRR-repeat protein 4F-box/SPRY domain-containing protein 1F-box and WD repeat domain containing 8F-box only protein 21 isoform X2F-box only protein 39Transport inhibitor response 1-like proteinF-box only protein 30F-box/kelch-repeat protein At3g61590F-box/WD repeat-containing protein 4 isoform X1F-box/WD repeat-containing protein 5 isoform X1F-box only protein 31Coronatine-insensitive protein homolog 2F-box/LRR-repeat protein 6 isoform X2F-box and leucine rich repeat protein 22F-box protein SKIP19F-box/LRR-repeat protein 17 isoform X3F-box and WD repeat domain containing 10protein UNUSUAL FLORAL ORGANSF-box only protein 48F-box protein 31F-box only protein 5F-box/WD repeat-containing protein 9 isoform X2F-box protein 7F-box protein 43Tubby-like F-box proteinF-box family protein-likeF-box protein 41F-box and leucine-rich repeat protein 4F-box and WD-40 domain-containing protein MET30F-box protein (Pof7), putativeF-box/LRR-repeat protein At3g48880F-box/SPRY domain-containing protein 1F-box/LRR-repeat protein 8F-box only protein 22OSJNBa0058K23.14 proteinPartner of PairedF-box only protein 13F-box only protein 15F-box/WD repeat-containing protein 9 isoform X2F-box domain containing protein, expressedOs05g0177100 proteinF-box protein SKIP23F-box protein SNEF-box protein GID2F-box domain containing proteinF-box/SPRY domain-containing protein 1F-box protein GID2Secretion pathway protein Sls2/Rcy1, putativeOs08g0230300 proteinF-box protein At5g07670GG17121F-box protein SKIP1F-box/WD repeat-containing protein 12EIN3-binding F-box protein 1F-box family proteinUnplaced genomic scaffold supercont1.46, whole genome shotgun sequenceF-box protein SKIP1Unplaced genomic scaffold supercont1.10, whole genome shotgun sequenceF-box only protein 42Lysine (K)-specific demethylase 2BEIN3-binding F-box protein 1F-box domain containing proteinExpressed proteinUFO1p F-box receptor proteinF-box and leucine-rich repeat protein 5F-box proteinF-box proteinF-box protein At5g67140F-box/WD repeat-containing protein 5 isoform X1F-box and leucine-rich repeat protein 18Predicted proteinF-box domain proteinMitochondria-associated F-box proteinF-box/kelch-repeat protein isoform AF-box/kelch-repeat protein At1g51550F-box protein dre-1Uncharacterized proteinPutative a receptor for ubiquitination targetsLeucine rich repeat containing 29GD11494Transport inhibitor response 1-like protein Os05g0150500Transcription factor jumonji domain-containing proteinJmjC domain-containing histone demethylation protein 1F-box domain containing protein, expressedF-box protein family-likePredicted proteinF-box and WD domain proteinF-box protein PP2-B1F-box domain containing protein, expressedF-box protein SKP2A isoform AF-box protein At4g02760-likeSCF ubiquitin ligase complex subunitF-box/WD repeat-containing protein lin-23GD22710Related to pyrimidine 5-nucleotidaseF-box/WD repeat-containing protein 1APutative scf ubiquitin ligase skp2 componentUncharacterized protein, isoform BWGS project CABT00000000 data, contig 2.25Zgc:171857Predicted proteinWGS project CABT00000000 data, contig 2.5Uncharacterized proteinLeucine rich repeat proteinAGAP008941-PAF-box and WD domain protein, putativeF-box/LRR-repeat protein 6Cyclic nucleotide-binding domain-containing proteinF-box domain containing protein, expressedFBD, F-box and Leucine Rich Repeat domains containing proteinF-box/WD repeat-containing protein sel-10F-box/wd-repeat protein lin-23, putativeChromosome 1, whole genome shotgun sequenceAGAP011930-PAF-box/SPRY domain-containing protein 1F-box only protein 7Uncharacterized proteinPredicted proteinUncharacterized protein, isoform CPredicted proteinDactylin, putativeOs05g0139300 proteinUncharacterized protein, isoform CGM17963F-box/kelch-repeat proteinF-box/kelch-repeat protein At5g42360F-box/LRR-repeat protein 6 isoform X1F-box/LRR-repeat protein 4Putative F-box protein At5g36200FBD-associated F-box protein At3g49020Uncharacterized proteinPredicted proteinUncharacterized proteinF-box and leucine rich repeat protein 18Uncharacterized proteinF-box and WD repeat domain containing 9Uncharacterized proteinProtein SUPPRESSOR OF NIM1 1uncharacterized protein LOC106571384 isoform X2F-box only protein 31Putative F-box only protein 11F-box domain protein (AFU_orthologue AFUA_3G00440)F-box only protein 31-BPutative f-box protein 31F-box protein At3g44326Uncharacterized proteinFbox domain-containing proteinF-box protein At2g02240Uncharacterized proteinProbable F-box protein At5g36000Uncharacterized proteinPredicted proteinPredicted proteinF-box-like, putativeGlucose-induced repressor, putativeUncharacterized proteinFbox domain-containing proteinPutative F-box/LRR-repeat protein 9F-box/LRR-repeat protein 4F-box only protein 39-likeSCF ubiquitin ligase complex subunitF-box/WD repeat-containing protein 4-like isoform X1F-box and WD repeat domain containing 4WD40-repeat-containing domain proteinUncharacterized proteinUncharacterized proteinLOC100145161 proteinPredicted proteinProtein CBG09205Ubiquitin-conjugating enzyme, putativeUncharacterized proteinPredicted proteinF-box/WD repeat-containing protein A-like proteinF-box only protein 6-like ProteinRho GTPase-activating protein gacFFPredicted proteinUncharacterized proteinPredicted proteinActin-related protein 8F-box DNA helicase 1 isoform X3Uncharacterized proteinUncharacterized proteinPredicted proteinOs09g0555300 proteinUncharacterized proteinCyclin-FSCF E3 ubiquitin ligase complex F-box protein grrAUncharacterized proteinPredicted proteinF-box/WD repeat-containing protein 4-like ProteinF-box protein 7Uncharacterized proteinPredicted proteinF-box/kelch-repeat protein At4g19930Uncharacterized proteinPutative F-box protein At3g47020Predicted proteinPutative F-box/LRR-repeat protein At5g25860Predicted proteinPutative F-box/LRR-repeat protein At3g42770Uncharacterized proteinF-box protein pof7F-box protein PP2-B7F-box protein pof6Predicted proteinPredicted proteinF-box protein pof12Predicted proteinUncharacterized proteinUncharacterized proteinF-box/LRR-repeat protein, putativeUncharacterized proteinF-box/leucine rich repeat protein, putativeF-box/leucine rich repeat protein, putativeUncharacterized proteinF-box/WD repeat-containing protein mec-15F-box and WD repeat domain-containing 11LOC100145488 proteinPredicted proteinF-box/WD repeat-containing protein pof11Chromosome 7, whole genome shotgun sequenceUncharacterized proteinUncharacterized proteinPredicted proteinF-box/LRR-repeat/kelch-repeat protein At1g09650Predicted proteinPutative F-box/kelch-repeat protein At1g12870Uncharacterized proteinPredicted proteinF-box protein At5g06550Ribonucleoside-diphosphate reductaseUncharacterized proteinF-box/WD repeat-containing protein AUncharacterized proteinUncharacterized proteinF-box protein 6Uncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinF-box protein pof9Uncharacterized proteinPredicted proteinPredicted proteinPredicted proteinF-box/leucine rich repeat protein, putativeELM2 domaincontaining proteinF-box/TPR repeat protein pof3Protein aardvarkMitogen-activated protein kinase kinase kinase A
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FunFam 36: F-box and leucine rich repeat protein 22

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
1 Q6P050 (/IDA)
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
1 Q8C7B6 (/ISO)
Showing 1 to 2 of 2 entries

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
1 Q6P050 (/TAS)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q6P050 (/IDA)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q8C7B6 (/ISO)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
1 Q6P050 (/TAS)
Showing 1 to 4 of 4 entries

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
6 H0YMQ4 (/IDA) H0YMQ4 (/IDA) H0YMQ4 (/IDA) H0YMQ4 (/IDA) H0YMQ4 (/IDA) Q6P050 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 H0YMQ4 (/IDA) H0YMQ4 (/IDA) H0YMQ4 (/IDA) H0YMQ4 (/IDA) H0YMQ4 (/IDA) Q6P050 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6P050 (/TAS)
SCF ubiquitin ligase complex GO:0019005
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
1 D3ZS59 (/IDA)
SCF ubiquitin ligase complex GO:0019005
A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
1 Q8C7B6 (/ISO)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 D3ZS59 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q8C7B6 (/ISO)
Showing 1 to 7 of 7 entries
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