The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: Interleukin-4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Interleukin-4 receptor binding GO:0005136
Interacting selectively and non-covalently with the interleukin-4 receptor.
3 P05112 (/TAS) P05112 (/TAS) P05112 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P05112 (/IPI) P05112 (/IPI) P05112 (/IPI)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
3 P05112 (/NAS) P05112 (/NAS) P05112 (/NAS)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
1 P07750 (/IDA)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
1 P20096 (/TAS)
Showing 1 to 5 of 5 entries

There are 138 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Positive regulation of macroautophagy GO:0016239
Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
41 O77762 (/ISS) P05112 (/ISS) P05112 (/ISS) P05112 (/ISS) P20096 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30368 (/ISS)
(31 more)
Positive regulation of B cell proliferation GO:0030890
Any process that activates or increases the rate or extent of B cell proliferation.
10 O77762 (/ISS) P05112 (/ISS) P05112 (/ISS) P05112 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P79155 (/ISS) P79339 (/ISS)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
10 O77762 (/ISS) P05112 (/ISS) P05112 (/ISS) P05112 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P79155 (/ISS) P79339 (/ISS)
Regulation of phosphorylation GO:0042325
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
10 O77762 (/ISS) P05112 (/ISS) P05112 (/ISS) P05112 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P79155 (/ISS) P79339 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
10 O77762 (/ISS) P05112 (/ISS) P05112 (/ISS) P05112 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P79155 (/ISS) P79339 (/ISS)
Positive regulation of MHC class II biosynthetic process GO:0045348
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.
10 O77762 (/ISS) P05112 (/ISS) P05112 (/ISS) P05112 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P79155 (/ISS) P79339 (/ISS)
Negative regulation of osteoclast differentiation GO:0045671
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
10 O77762 (/ISS) P05112 (/ISS) P05112 (/ISS) P05112 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P79155 (/ISS) P79339 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
10 O77762 (/ISS) P05112 (/ISS) P05112 (/ISS) P05112 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P79155 (/ISS) P79339 (/ISS)
Positive regulation of isotype switching to IgE isotypes GO:0048295
Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes.
10 O77762 (/ISS) P05112 (/ISS) P05112 (/ISS) P05112 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P79155 (/ISS) P79339 (/ISS)
Positive regulation of isotype switching to IgG isotypes GO:0048304
Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes.
10 O77762 (/ISS) P05112 (/ISS) P05112 (/ISS) P05112 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P79155 (/ISS) P79339 (/ISS)
Showing 1 to 10 of 138 entries

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
7 O77762 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P30367 (/ISS) P79155 (/ISS) P79339 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 P05112 (/TAS) P05112 (/TAS) P05112 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P05112 (/TAS) P05112 (/TAS) P05112 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P07750 (/IDA) P20096 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P07750 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 P07750 (/IDA)
Showing 1 to 6 of 6 entries
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