CATH Superfamily 1.20.1250.10
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 13: Erythropoietin
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Erythropoietin receptor binding GO:0005128
Interacting selectively and non-covalently with the erythropoietin receptor.
|
13 |
A3FFS8 (/ISS)
P07321 (/ISS)
P07321 (/ISS)
P07865 (/ISS)
P29676 (/ISS)
P33707 (/ISS)
P33708 (/ISS)
P33709 (/ISS)
P48617 (/ISS)
P49157 (/ISS)
(3 more) |
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
2 | P01588 (/IDA) P01588 (/IDA) |
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Erythropoietin receptor binding GO:0005128
Interacting selectively and non-covalently with the erythropoietin receptor.
|
2 | P01588 (/IMP) P01588 (/IMP) |
Erythropoietin receptor binding GO:0005128
Interacting selectively and non-covalently with the erythropoietin receptor.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Erythropoietin receptor binding GO:0005128
Interacting selectively and non-covalently with the erythropoietin receptor.
|
2 | P07321 (/TAS) P07321 (/TAS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P01588 (/IPI) P01588 (/IPI) |
Protein kinase activator activity GO:0030295
Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
|
2 | P07321 (/IDA) P07321 (/IDA) |
There are 76 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
13 |
A3FFS8 (/ISS)
P07321 (/ISS)
P07321 (/ISS)
P07865 (/ISS)
P29676 (/ISS)
P33707 (/ISS)
P33708 (/ISS)
P33709 (/ISS)
P48617 (/ISS)
P49157 (/ISS)
(3 more) |
Erythropoietin-mediated signaling pathway GO:0038162
A series of molecular signals initiated by the binding of erythropoietin (EPO) to the erythropoietin receptor (EPO-R) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
13 |
A3FFS8 (/ISS)
P07321 (/ISS)
P07321 (/ISS)
P07865 (/ISS)
P29676 (/ISS)
P33707 (/ISS)
P33708 (/ISS)
P33709 (/ISS)
P48617 (/ISS)
P49157 (/ISS)
(3 more) |
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
11 |
A3FFS8 (/ISS)
P07865 (/ISS)
P29676 (/ISS)
P33707 (/ISS)
P33708 (/ISS)
P33709 (/ISS)
P48617 (/ISS)
P49157 (/ISS)
Q28513 (/ISS)
Q867B1 (/ISS)
(1 more) |
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
4 | P01588 (/IDA) P01588 (/IDA) P07321 (/IDA) P07321 (/IDA) |
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P01588 (/IMP) P01588 (/IMP) |
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
2 | P07321 (/TAS) P07321 (/TAS) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
2 | P07321 (/IDA) P07321 (/IDA) |
Heart morphogenesis GO:0003007
The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
2 | P07321 (/TAS) P07321 (/TAS) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | P07321 (/IDA) P07321 (/IDA) |
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
2 | P07321 (/IDA) P07321 (/IDA) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
2 | P01588 (/NAS) P01588 (/NAS) |
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
|
2 | P07321 (/IDA) P07321 (/IDA) |
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
|
2 | P01588 (/NAS) P01588 (/NAS) |
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
2 | P01588 (/IMP) P01588 (/IMP) |
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | P01588 (/IDA) P01588 (/IDA) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Negative regulation of calcium ion transport into cytosol GO:0010523
Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
|
2 | P01588 (/IDA) P01588 (/IDA) |
Negative regulation of calcium ion transport into cytosol GO:0010523
Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | P07321 (/ISO) P07321 (/ISO) |
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
2 | P01588 (/TAS) P01588 (/TAS) |
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
2 | P07321 (/IDA) P07321 (/IDA) |
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
2 | P01588 (/IMP) P01588 (/IMP) |
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Negative regulation of myeloid cell apoptotic process GO:0033033
Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.
|
2 | P07321 (/IDA) P07321 (/IDA) |
Erythropoietin-mediated signaling pathway GO:0038162
A series of molecular signals initiated by the binding of erythropoietin (EPO) to the erythropoietin receptor (EPO-R) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P01588 (/IMP) P01588 (/IMP) |
Erythropoietin-mediated signaling pathway GO:0038162
A series of molecular signals initiated by the binding of erythropoietin (EPO) to the erythropoietin receptor (EPO-R) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
2 | P01588 (/IDA) P01588 (/IDA) |
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Hemoglobin biosynthetic process GO:0042541
The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.
|
2 | P07321 (/IDA) P07321 (/IDA) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | P07321 (/IDA) P07321 (/IDA) |
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
|
2 | P07321 (/IDA) P07321 (/IDA) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P01588 (/IDA) P01588 (/IDA) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
|
2 | P01588 (/IDA) P01588 (/IDA) |
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
|
2 | P01588 (/TAS) P01588 (/TAS) |
Cardiac muscle tissue morphogenesis GO:0055008
The process in which the anatomical structures of cardiac muscle tissue are generated and organized.
|
2 | P07321 (/TAS) P07321 (/TAS) |
Ventricular cardiac muscle tissue morphogenesis GO:0055010
The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.
|
2 | P07321 (/TAS) P07321 (/TAS) |
Vasculogenesis involved in coronary vascular morphogenesis GO:0060979
The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes.
|
2 | P07321 (/TAS) P07321 (/TAS) |
Visceral serous pericardium development GO:0061032
The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.
|
2 | P07321 (/TAS) P07321 (/TAS) |
Regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
|
2 | P01588 (/TAS) P01588 (/TAS) |
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Cellular hyperosmotic response GO:0071474
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
|
2 | P01588 (/IDA) P01588 (/IDA) |
Cellular hyperosmotic response GO:0071474
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902219
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress.
|
2 | P01588 (/IDA) P01588 (/IDA) |
Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress GO:1902219
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Negative regulation of erythrocyte apoptotic process GO:1902251
Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process.
|
2 | P01588 (/IDA) P01588 (/IDA) |
Negative regulation of erythrocyte apoptotic process GO:1902251
Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Negative regulation of cation channel activity GO:2001258
Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity.
|
2 | P01588 (/IDA) P01588 (/IDA) |
Negative regulation of cation channel activity GO:2001258
Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | P29676 (/IEP) |
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | P29676 (/TAS) |
Acute-phase response GO:0006953
An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
|
1 | P29676 (/IEP) |
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | P29676 (/IEP) |
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
|
1 | P29676 (/IEP) |
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | P29676 (/IMP) |
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
|
1 | P29676 (/IEP) |
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P29676 (/IDA) |
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | P29676 (/IEP) |
Response to vitamin A GO:0033189
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.
|
1 | P29676 (/IEP) |
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
|
1 | P29676 (/IEP) |
Positive regulation of activated T cell proliferation GO:0042104
Any process that activates or increases the rate or extent of activated T cell proliferation.
|
1 | P29676 (/IDA) |
Response to estrogen GO:0043627
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
|
1 | P29676 (/IEP) |
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
|
1 | P29676 (/IDA) |
Response to axon injury GO:0048678
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
|
1 | P29676 (/IEP) |
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
|
1 | P29676 (/IEP) |
Response to hyperoxia GO:0055093
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.
|
1 | P29676 (/IEP) |
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | P29676 (/IMP) |
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
1 | P29676 (/IEP) |
Response to dexamethasone GO:0071548
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
|
1 | P29676 (/IEP) |
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
1 | P29676 (/IDA) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
5 | P01588 (/IDA) P01588 (/IDA) P07321 (/IDA) P07321 (/IDA) P29676 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
4 | P01588 (/TAS) P01588 (/TAS) P07321 (/TAS) P07321 (/TAS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | P01588 (/IDA) P01588 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
|
2 | P07321 (/ISO) P07321 (/ISO) |
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
|
1 | P29676 (/IDA) |