The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Serine carboxypeptidase S28, SKS domain
".
FunFam 2: lysosomal Pro-X carboxypeptidase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Serine-type carboxypeptidase activity GO:0004185
Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
|
2 | P42785 (/TAS) P42785 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P42785 (/IPI) P42785 (/IPI) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Blood coagulation, intrinsic pathway GO:0007597
A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.
|
2 | P42785 (/TAS) P42785 (/TAS) |
|
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
2 | P42785 (/TAS) P42785 (/TAS) |
|
Regulation of blood vessel endothelial cell migration GO:0043535
Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
|
2 | Q2TA14 (/IMP) Q7TMR0 (/IMP) |
|
Regulation of thyroid hormone mediated signaling pathway GO:0002155
Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.
|
1 | Q7TMR0 (/IMP) |
|
Plasma kallikrein-kinin cascade GO:0002353
A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.
|
1 | Q7TMR0 (/IMP) |
|
Negative regulation of systemic arterial blood pressure GO:0003085
The process that reduces the force with which blood travels through the systemic arterial circulatory system.
|
1 | Q7TMR0 (/IMP) |
|
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
1 | Q7TMR0 (/IMP) |
|
Regulation of blood vessel endothelial cell migration GO:0043535
Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
|
1 | Q7TMR0 (/ISO) |
|
Angiogenesis involved in wound healing GO:0060055
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury.
|
1 | Q7TMR0 (/IMP) |
|
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
|
1 | Q7TMR0 (/IMP) |
|
Regulation of reactive oxygen species metabolic process GO:2000377
Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
|
1 | Q7TMR0 (/IMP) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P42785 (/TAS) P42785 (/TAS) |
|
Azurophil granule membrane GO:0035577
The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
|
2 | P42785 (/TAS) P42785 (/TAS) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | P42785 (/HDA) P42785 (/HDA) |
|
Ficolin-1-rich granule membrane GO:0101003
The lipid bilayer surrounding a ficolin-1-rich granule.
|
2 | P42785 (/TAS) P42785 (/TAS) |
|
Basal part of cell GO:0045178
The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.
|
1 | Q7TMR0 (/IDA) |
