The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Myosin VI head, motor domain, U50 subdomain
".
FunFam 1: Myosin heavy chain, muscle
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 49 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
10 | A7E2Y1 (/IPI) O14157 (/IPI) P02566 (/IPI) P12882 (/IPI) P12883 (/IPI) P13542 (/IPI) Q02566 (/IPI) Q02566 (/IPI) Q9UKX2 (/IPI) Q9USI6 (/IPI) |
|
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
|
6 | P02563 (/IMP) P02564 (/IMP) P11055 (/IMP) P13535 (/IMP) Q02566 (/IMP) Q02566 (/IMP) |
|
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
|
6 | P13541 (/ISO) P13542 (/ISO) Q02566 (/ISO) Q02566 (/ISO) Q91Z83 (/ISO) Q91Z83 (/ISO) |
|
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
|
6 | A0A0G2K0F5 (/TAS) A0A0G2K1V4 (/TAS) A0A0G2K484 (/TAS) F1LRV9 (/TAS) Q9UKX2 (/TAS) Q9UKX3 (/TAS) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
5 | P13542 (/ISO) Q02566 (/ISO) Q02566 (/ISO) Q91Z83 (/ISO) Q91Z83 (/ISO) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
5 | P13542 (/ISO) Q02566 (/ISO) Q02566 (/ISO) Q91Z83 (/ISO) Q91Z83 (/ISO) |
|
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
|
4 | P02566 (/IDA) P12883 (/IDA) P13533 (/IDA) Q9USI6 (/IDA) |
|
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
|
4 | A0A0G2K0F5 (/TAS) A0A0G2K1V4 (/TAS) A0A0G2K484 (/TAS) F1LRV9 (/TAS) |
|
Actin-dependent ATPase activity GO:0030898
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate.
|
4 | Q02566 (/ISO) Q02566 (/ISO) Q91Z83 (/ISO) Q91Z83 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
4 | Q02566 (/ISO) Q02566 (/ISO) Q91Z83 (/ISO) Q91Z83 (/ISO) |
Showing 1 to 10 of 49 entries
There are 159 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Slow-twitch skeletal muscle fiber contraction GO:0031444
A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.
|
13 |
A0A0G2L6C1 (/IGI)
A0A0N4STT5 (/IGI)
A0A0N4SU68 (/IGI)
A0A0R4INI3 (/IGI)
A0A2R8Q7G9 (/IGI)
A0A2R8Q8V2 (/IGI)
A0MQ61 (/IGI)
A4IGA2 (/IGI)
B1WB81 (/IGI)
B3DK50 (/IGI)
(3 more) |
|
Skeletal muscle thin filament assembly GO:0030240
The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle.
|
9 | A0A0R4INI3 (/IMP) A0A2R8Q7G9 (/IMP) A0A2R8Q8V2 (/IMP) A0MQ61 (/IMP) A4IGA2 (/IMP) B1WB81 (/IMP) B3DK50 (/IMP) Q503C6 (/IMP) Q508P8 (/IMP) |
|
Striated muscle myosin thick filament assembly GO:0071688
The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle.
|
9 | A0A0R4INI3 (/IMP) A0A2R8Q7G9 (/IMP) A0A2R8Q8V2 (/IMP) A0MQ61 (/IMP) A4IGA2 (/IMP) B1WB81 (/IMP) B3DK50 (/IMP) Q503C6 (/IMP) Q508P8 (/IMP) |
|
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
|
8 | A0A0G2K0F5 (/IDA) A0A0G2K1V4 (/IDA) A0A0G2K484 (/IDA) F1LRV9 (/IDA) P12883 (/IDA) P13533 (/IDA) Q9UKX2 (/IDA) Q9Y623 (/IDA) |
|
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
|
8 | G3UW82 (/ISO) I6L963 (/ISO) Q02566 (/ISO) Q02566 (/ISO) Q5SX39 (/ISO) Q5SX40 (/ISO) Q91Z83 (/ISO) Q91Z83 (/ISO) |
|
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
|
7 | A0JMC2 (/IDA) A5D6S9 (/IDA) G3UW82 (/IDA) I6L963 (/IDA) Q1JPZ0 (/IDA) Q5SX39 (/IDA) Q6IQX1 (/IDA) |
|
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
|
6 | P02563 (/IMP) P02564 (/IMP) P02566 (/IMP) P02567 (/IMP) P05661 (/IMP) Q99323 (/IMP) |
|
ATP metabolic process GO:0046034
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
|
6 | P13541 (/ISO) P13542 (/ISO) Q02566 (/ISO) Q02566 (/ISO) Q91Z83 (/ISO) Q91Z83 (/ISO) |
|
Adult heart development GO:0007512
The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.
|
5 | P12883 (/IMP) P13533 (/IMP) Q02566 (/IMP) Q02566 (/IMP) Q910C5 (/IMP) |
|
Muscle filament sliding GO:0030049
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.
|
5 | P13542 (/ISO) Q02566 (/ISO) Q02566 (/ISO) Q91Z83 (/ISO) Q91Z83 (/ISO) |
Showing 1 to 10 of 159 entries
There are 75 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
12 |
B1AR69 (/IDA)
G3UW82 (/IDA)
I6L963 (/IDA)
P02563 (/IDA)
P02564 (/IDA)
Q02566 (/IDA)
Q02566 (/IDA)
Q91Z83 (/IDA)
Q91Z83 (/IDA)
Q9BE41 (/IDA)
(2 more) |
|
Sarcomere GO:0030017
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
9 | P12883 (/ISS) P13540 (/ISS) P49824 (/ISS) P79293 (/ISS) P79293 (/ISS) Q8MJU9 (/ISS) Q91Z83 (/ISS) Q91Z83 (/ISS) Q9BE39 (/ISS) |
|
Muscle myosin complex GO:0005859
A filament of myosin found in a muscle cell of any type.
|
8 | A0A0G2K0F5 (/IDA) A0A0G2K1V4 (/IDA) A0A0G2K484 (/IDA) F1LRV9 (/IDA) P02563 (/IDA) P02564 (/IDA) P02566 (/IDA) P12882 (/IDA) |
|
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
8 | P12883 (/ISS) P13533 (/ISS) P13540 (/ISS) P49824 (/ISS) P79293 (/ISS) P79293 (/ISS) Q8MJU9 (/ISS) Q9BE39 (/ISS) |
|
Myosin filament GO:0032982
A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.
|
8 | P13540 (/ISS) P49824 (/ISS) P79293 (/ISS) P79293 (/ISS) Q8MJU9 (/ISS) Q91Z83 (/ISS) Q91Z83 (/ISS) Q9BE39 (/ISS) |
|
Muscle myosin complex GO:0005859
A filament of myosin found in a muscle cell of any type.
|
7 | G3UW82 (/ISO) I6L963 (/ISO) Q02566 (/ISO) Q02566 (/ISO) Q5SX40 (/ISO) Q91Z83 (/ISO) Q91Z83 (/ISO) |
|
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
7 | G3UW82 (/ISO) I6L963 (/ISO) Q02566 (/ISO) Q02566 (/ISO) Q5SX39 (/ISO) Q91Z83 (/ISO) Q91Z83 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | O14157 (/IDA) P02563 (/IDA) P13535 (/IDA) Q91Z83 (/IDA) Q91Z83 (/IDA) Q9USI6 (/IDA) |
|
Myosin complex GO:0016459
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
|
6 | P13541 (/IDA) P13542 (/IDA) Q02566 (/IDA) Q02566 (/IDA) Q91Z83 (/IDA) Q91Z83 (/IDA) |
|
A band GO:0031672
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.
|
6 | G3UW82 (/IDA) I6L963 (/IDA) P02566 (/IDA) P05661 (/IDA) P12844 (/IDA) Q5SX40 (/IDA) |
Showing 1 to 10 of 75 entries
