The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Apolipoprotein
".
FunFam 6: Apolipoprotein A-V
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 22 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Phosphatidylcholine binding GO:0031210
Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Lipase binding GO:0035473
Interacting selectively and non-covalently with any lipase.
|
2 | Q6Q788 (/IPI) Q6Q788 (/IPI) |
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
|
2 | Q6Q788 (/IPI) Q6Q788 (/IPI) |
Lipase activator activity GO:0060229
Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.
|
2 | Q6Q788 (/IMP) Q6Q788 (/IMP) |
Lipoprotein lipase activator activity GO:0060230
Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Lipoprotein particle receptor binding GO:0070325
Interacting selectively and non-covalently with a lipoprotein particle receptor.
|
2 | Q6Q788 (/IPI) Q6Q788 (/IPI) |
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
1 | Q8C7G5 (/ISO) |
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
|
1 | Q8C7G5 (/ISO) |
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
1 | Q8C7G5 (/ISO) |
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
|
1 | Q8C7G5 (/ISO) |
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | Q8C7G5 (/ISO) |
Phosphatidylcholine binding GO:0031210
Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.
|
1 | Q8C7G5 (/ISO) |
Lipase binding GO:0035473
Interacting selectively and non-covalently with any lipase.
|
1 | Q8C7G5 (/ISO) |
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
|
1 | Q8C7G5 (/ISO) |
Lipase activator activity GO:0060229
Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid.
|
1 | Q8C7G5 (/ISO) |
Lipoprotein lipase activator activity GO:0060230
Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein.
|
1 | Q8C7G5 (/ISO) |
Lipoprotein particle receptor binding GO:0070325
Interacting selectively and non-covalently with a lipoprotein particle receptor.
|
1 | Q8C7G5 (/ISO) |
There are 34 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Triglyceride metabolic process GO:0006641
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
|
3 | Q6Q788 (/IMP) Q6Q788 (/IMP) Q8C7G5 (/IMP) |
Acylglycerol homeostasis GO:0055090
Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell.
|
3 | Q6Q788 (/IMP) Q6Q788 (/IMP) Q8C7G5 (/IMP) |
Triglyceride metabolic process GO:0006641
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Lipid transport GO:0006869
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Positive regulation of triglyceride catabolic process GO:0010898
Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Positive regulation of very-low-density lipoprotein particle remodeling GO:0010902
Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
2 | Q6Q788 (/TAS) Q6Q788 (/TAS) |
Triglyceride catabolic process GO:0019433
The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.
|
2 | Q6Q788 (/IMP) Q6Q788 (/IMP) |
Tissue regeneration GO:0042246
The regrowth of lost or destroyed tissues.
|
2 | Q6Q788 (/IEP) Q6Q788 (/IEP) |
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
|
2 | Q6Q788 (/TAS) Q6Q788 (/TAS) |
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
2 | Q6Q788 (/TAS) Q6Q788 (/TAS) |
Positive regulation of fatty acid biosynthetic process GO:0045723
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Positive regulation of receptor-mediated endocytosis GO:0048260
Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
|
2 | Q6Q788 (/TAS) Q6Q788 (/TAS) |
Positive regulation of lipid catabolic process GO:0050996
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Positive regulation of lipoprotein lipase activity GO:0051006
Any process that activates or increases the activity of the enzyme lipoprotein lipase.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Acylglycerol homeostasis GO:0055090
Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Triglyceride homeostasis GO:0070328
Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Triglyceride homeostasis GO:0070328
Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.
|
2 | Q6Q788 (/IMP) Q6Q788 (/IMP) |
Triglyceride metabolic process GO:0006641
The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.
|
1 | Q8C7G5 (/ISO) |
Lipid transport GO:0006869
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
|
1 | Q9QUH3 (/IMP) |
Lipid transport GO:0006869
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
|
1 | Q8C7G5 (/ISO) |
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | Q9QUH3 (/IEP) |
Positive regulation of triglyceride catabolic process GO:0010898
Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
|
1 | Q8C7G5 (/ISO) |
Positive regulation of very-low-density lipoprotein particle remodeling GO:0010902
Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.
|
1 | Q8C7G5 (/ISO) |
Triglyceride catabolic process GO:0019433
The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.
|
1 | Q8C7G5 (/ISO) |
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
|
1 | Q9QUH3 (/IEP) |
Triglyceride-rich lipoprotein particle remodeling GO:0034370
The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle.
|
1 | Q8C7G5 (/IMP) |
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
1 | Q8C7G5 (/ISO) |
Positive regulation of fatty acid biosynthetic process GO:0045723
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
|
1 | Q8C7G5 (/ISO) |
Positive regulation of lipid catabolic process GO:0050996
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.
|
1 | Q8C7G5 (/ISO) |
Positive regulation of lipoprotein lipase activity GO:0051006
Any process that activates or increases the activity of the enzyme lipoprotein lipase.
|
1 | Q8C7G5 (/ISO) |
Acylglycerol homeostasis GO:0055090
Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell.
|
1 | Q8C7G5 (/ISO) |
Triglyceride homeostasis GO:0070328
Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.
|
1 | Q8C7G5 (/ISO) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
3 | Q6Q788 (/IDA) Q6Q788 (/IDA) Q9QUH3 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
2 | Q6Q788 (/TAS) Q6Q788 (/TAS) |
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
2 | Q6Q788 (/TAS) Q6Q788 (/TAS) |
Very-low-density lipoprotein particle GO:0034361
A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
High-density lipoprotein particle GO:0034364
A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Chylomicron GO:0042627
A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.
|
2 | Q6Q788 (/IDA) Q6Q788 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | Q8C7G5 (/ISO) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q8C7G5 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8C7G5 (/TAS) |
Very-low-density lipoprotein particle GO:0034361
A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver.
|
1 | Q8C7G5 (/ISO) |
High-density lipoprotein particle GO:0034364
A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.
|
1 | Q8C7G5 (/ISO) |
Chylomicron GO:0042627
A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.
|
1 | Q8C7G5 (/ISO) |