The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Apolipoprotein
".
FunFam 26: Apolipoprotein E
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
|
1 | P23529 (/ISS) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P23529 (/ISS) |
|
Heparan sulfate proteoglycan binding GO:0043395
Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
|
1 | P23529 (/ISS) |
|
Low-density lipoprotein particle receptor binding GO:0050750
Interacting selectively and non-covalently with a low-density lipoprotein receptor.
|
1 | P23529 (/ISS) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
|
1 | P23529 (/ISS) |
|
High-density lipoprotein particle assembly GO:0034380
The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.
|
1 | P23529 (/ISS) |
|
Chylomicron remnant clearance GO:0034382
The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded.
|
1 | P23529 (/ISS) |
|
Very-low-density lipoprotein particle clearance GO:0034447
The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
|
1 | P23529 (/ISS) |
|
Lipoprotein biosynthetic process GO:0042158
The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
|
1 | P23529 (/ISS) |
|
Triglyceride-rich lipoprotein particle clearance GO:0071830
The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
|
1 | P23529 (/ISS) |
|
Intermediate-density lipoprotein particle clearance GO:0071831
The process in which a intermediate-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
|
1 | P23529 (/ISS) |
|
Positive regulation of amyloid-beta clearance GO:1900223
Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance.
|
1 | P23529 (/ISS) |
|
Negative regulation of amyloid fibril formation GO:1905907
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.
|
1 | P23529 (/ISS) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P23529 (/ISS) |
|
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
|
1 | P23529 (/ISS) |
|
Very-low-density lipoprotein particle GO:0034361
A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver.
|
1 | P23529 (/ISS) |
|
Low-density lipoprotein particle GO:0034362
A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver.
|
1 | P23529 (/ISS) |
|
Intermediate-density lipoprotein particle GO:0034363
A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL).
|
1 | P23529 (/ISS) |
|
High-density lipoprotein particle GO:0034364
A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.
|
1 | P23529 (/ISS) |
