The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Paired amphipathic helix
".
FunFam 2: Paired amphipathic helix protein SIN3
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 24 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
12 |
A0A0B4K765 (/IDA)
A0A0B4LF82 (/IDA)
A0A0B4LF93 (/IDA)
A0A126GUN9 (/IDA)
A1Z927 (/IDA)
A1Z928 (/IDA)
O17142 (/IDA)
O17143 (/IDA)
O77025 (/IDA)
Q5U0Y0 (/IDA)
(2 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
A0A0G2K3H5 (/IPI)
D3ZBP2 (/IPI)
O13919 (/IPI)
O75182 (/IPI)
P22579 (/IPI)
Q09750 (/IPI)
Q60520 (/IPI)
Q62141 (/IPI)
Q96ST3 (/IPI)
Q96ST3 (/IPI)
(1 more) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
10 | A0A0B4K765 (/NAS) A0A0B4LF82 (/NAS) A0A0B4LF93 (/NAS) A0A126GUN9 (/NAS) A1Z927 (/NAS) A1Z928 (/NAS) O17142 (/NAS) O17143 (/NAS) O77025 (/NAS) Q5U0Y0 (/NAS) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
10 | A0A0B4K765 (/IPI) A0A0B4LF82 (/IPI) A0A0B4LF93 (/IPI) A0A126GUN9 (/IPI) A1Z927 (/IPI) A1Z928 (/IPI) O17142 (/IPI) O17143 (/IPI) O77025 (/IPI) Q5U0Y0 (/IPI) |
|
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
2 | Q96ST3 (/ISS) Q96ST3 (/ISS) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
2 | Q96ST3 (/IPI) Q96ST3 (/IPI) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | A0A1D8PCC3 (/IDA) Q60520 (/IDA) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | A0A1D8PCC3 (/IMP) Q60520 (/IMP) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
2 | Q60520 (/IDA) Q62141 (/IDA) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | A0A0G2K3H5 (/IDA) D3ZBP2 (/IDA) |
|
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
|
2 | Q96ST3 (/IMP) Q96ST3 (/IMP) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
2 | A0A0G2K3H5 (/IDA) D3ZBP2 (/IDA) |
|
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
1 | Q60520 (/IDA) |
|
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
1 | Q60520 (/ISO) |
|
RNA polymerase II repressing transcription factor binding GO:0001103
Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.
|
1 | Q60520 (/IPI) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | P22579 (/IMP) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q60520 (/IGI) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | P22579 (/IMP) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | P22579 (/IPI) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q60520 (/ISO) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | Q60520 (/IPI) |
|
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
|
1 | Q60520 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P22579 (/IPI) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q60520 (/ISO) |
There are 86 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
11 |
A0A0B4K765 (/IEP)
A0A0B4LF82 (/IEP)
A0A0B4LF93 (/IEP)
A0A126GUN9 (/IEP)
A1Z927 (/IEP)
A1Z928 (/IEP)
O17142 (/IEP)
O17143 (/IEP)
O48686 (/IEP)
O77025 (/IEP)
(1 more) |
|
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
|
10 | A0A0B4K765 (/IMP) A0A0B4LF82 (/IMP) A0A0B4LF93 (/IMP) A0A126GUN9 (/IMP) A1Z927 (/IMP) A1Z928 (/IMP) O17142 (/IMP) O17143 (/IMP) O77025 (/IMP) Q5U0Y0 (/IMP) |
|
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
|
10 | A0A0B4K765 (/IEP) A0A0B4LF82 (/IEP) A0A0B4LF93 (/IEP) A0A126GUN9 (/IEP) A1Z927 (/IEP) A1Z928 (/IEP) O17142 (/IEP) O17143 (/IEP) O77025 (/IEP) Q5U0Y0 (/IEP) |
|
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
|
10 | A0A0B4K765 (/IMP) A0A0B4LF82 (/IMP) A0A0B4LF93 (/IMP) A0A126GUN9 (/IMP) A1Z927 (/IMP) A1Z928 (/IMP) O17142 (/IMP) O17143 (/IMP) O77025 (/IMP) Q5U0Y0 (/IMP) |
|
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
10 | A0A0B4K765 (/IMP) A0A0B4LF82 (/IMP) A0A0B4LF93 (/IMP) A0A126GUN9 (/IMP) A1Z927 (/IMP) A1Z928 (/IMP) O17142 (/IMP) O17143 (/IMP) O77025 (/IMP) Q5U0Y0 (/IMP) |
|
Epithelial cell migration GO:0010631
The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.
|
10 | A0A0B4K765 (/IMP) A0A0B4LF82 (/IMP) A0A0B4LF93 (/IMP) A0A126GUN9 (/IMP) A1Z927 (/IMP) A1Z928 (/IMP) O17142 (/IMP) O17143 (/IMP) O77025 (/IMP) Q5U0Y0 (/IMP) |
|
Negative regulation of epithelial cell migration GO:0010633
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
|
10 | A0A0B4K765 (/IGI) A0A0B4LF82 (/IGI) A0A0B4LF93 (/IGI) A0A126GUN9 (/IGI) A1Z927 (/IGI) A1Z928 (/IGI) O17142 (/IGI) O17143 (/IGI) O77025 (/IGI) Q5U0Y0 (/IGI) |
|
Regulation of protein stability GO:0031647
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.
|
10 | A0A0B4K765 (/IMP) A0A0B4LF82 (/IMP) A0A0B4LF93 (/IMP) A0A126GUN9 (/IMP) A1Z927 (/IMP) A1Z928 (/IMP) O17142 (/IMP) O17143 (/IMP) O77025 (/IMP) Q5U0Y0 (/IMP) |
|
Regulation of hemocyte proliferation GO:0035206
Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.
|
10 | A0A0B4K765 (/IMP) A0A0B4LF82 (/IMP) A0A0B4LF93 (/IMP) A0A126GUN9 (/IMP) A1Z927 (/IMP) A1Z928 (/IMP) O17142 (/IMP) O17143 (/IMP) O77025 (/IMP) Q5U0Y0 (/IMP) |
|
Wing disc development GO:0035220
Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura.
|
10 | A0A0B4K765 (/IMP) A0A0B4LF82 (/IMP) A0A0B4LF93 (/IMP) A0A126GUN9 (/IMP) A1Z927 (/IMP) A1Z928 (/IMP) O17142 (/IMP) O17143 (/IMP) O77025 (/IMP) Q5U0Y0 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
10 | A0A0B4K765 (/IMP) A0A0B4LF82 (/IMP) A0A0B4LF93 (/IMP) A0A126GUN9 (/IMP) A1Z927 (/IMP) A1Z928 (/IMP) O17142 (/IMP) O17143 (/IMP) O77025 (/IMP) Q5U0Y0 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
10 | A0A0B4K765 (/TAS) A0A0B4LF82 (/TAS) A0A0B4LF93 (/TAS) A0A126GUN9 (/TAS) A1Z927 (/TAS) A1Z928 (/TAS) O17142 (/TAS) O17143 (/TAS) O77025 (/TAS) Q5U0Y0 (/TAS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
4 | A0A1D8PCC3 (/IMP) P22579 (/IMP) Q96ST3 (/IMP) Q96ST3 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | O48686 (/IDA) Q60520 (/IDA) Q62141 (/IDA) Q9SRH9 (/IDA) |
|
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
3 | O75182 (/TAS) Q96ST3 (/TAS) Q96ST3 (/TAS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | P22579 (/IMP) Q96ST3 (/IMP) Q96ST3 (/IMP) |
|
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
|
2 | Q96ST3 (/IMP) Q96ST3 (/IMP) |
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
2 | Q96ST3 (/IMP) Q96ST3 (/IMP) |
|
Protein deacetylation GO:0006476
The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
|
2 | Q96ST3 (/IMP) Q96ST3 (/IMP) |
|
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
2 | A0A0G2K3H5 (/IDA) D3ZBP2 (/IDA) |
|
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
|
2 | A0A0G2K3H5 (/IDA) D3ZBP2 (/IDA) |
|
Regulation of hormone levels GO:0010817
Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.
|
2 | A0A0G2K3H5 (/IMP) D3ZBP2 (/IMP) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
2 | O13919 (/IMP) P22579 (/IMP) |
|
Cerebral cortex neuron differentiation GO:0021895
The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.
|
2 | Q96ST3 (/ISS) Q96ST3 (/ISS) |
|
Regulation of axon extension GO:0030516
Any process that modulates the rate, direction or extent of axon extension.
|
2 | Q96ST3 (/ISS) Q96ST3 (/ISS) |
|
Positive regulation of chromatin silencing GO:0031937
Any process that activates or increases the frequency, rate or extent of chromatin silencing.
|
2 | Q96ST3 (/IMP) Q96ST3 (/IMP) |
|
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
|
2 | Q96ST3 (/ISS) Q96ST3 (/ISS) |
|
Regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619
Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
2 | A0A0G2K3H5 (/IDA) D3ZBP2 (/IDA) |
|
Regulation of megakaryocyte differentiation GO:0045652
Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
|
2 | Q96ST3 (/TAS) Q96ST3 (/TAS) |
|
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
|
2 | Q96ST3 (/ISS) Q96ST3 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q96ST3 (/ISS) Q96ST3 (/ISS) |
|
Negative regulation of protein localization to nucleus GO:1900181
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.
|
2 | Q96ST3 (/IMP) Q96ST3 (/IMP) |
|
Negative regulation of histone H3-K27 acetylation GO:1901675
Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 acetylation.
|
2 | Q96ST3 (/IMP) Q96ST3 (/IMP) |
|
Cellular response to dopamine GO:1903351
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus.
|
2 | A0A0G2K3H5 (/IEP) D3ZBP2 (/IEP) |
|
Negative regulation of transcription regulatory region DNA binding GO:2000678
Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.
|
2 | Q96ST3 (/IMP) Q96ST3 (/IMP) |
|
Regulation of transcription involved in G2/M transition of mitotic cell cycle GO:0000117
Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle.
|
1 | P22579 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q60520 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q60520 (/ISO) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | A0A1D8PCC3 (/ISS) |
|
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
|
1 | Q60520 (/IMP) |
|
Activation of innate immune response GO:0002218
Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
|
1 | Q60520 (/ISO) |
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
1 | Q60520 (/ISO) |
|
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
|
1 | Q60520 (/IMP) |
|
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
1 | Q60520 (/IMP) |
|
Double-strand break repair via nonhomologous end joining GO:0006303
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
|
1 | P22579 (/IMP) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | O13919 (/IC) |
|
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
|
1 | Q09750 (/ISO) |
|
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
|
1 | O13919 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q60520 (/IMP) |
|
Protein deacetylation GO:0006476
The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
|
1 | Q60520 (/ISO) |
|
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | Q60520 (/ISO) |
|
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
|
1 | A0A1D8PCC3 (/IMP) |
|
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
|
1 | O48686 (/IMP) |
|
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
|
1 | Q60520 (/ISO) |
|
Regulation of hormone levels GO:0010817
Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.
|
1 | Q60520 (/ISO) |
|
Positive regulation of G2/M transition of mitotic cell cycle GO:0010971
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
|
1 | Q60520 (/IMP) |
|
Negative regulation of transcription by RNA polymerase I GO:0016479
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I.
|
1 | P22579 (/IMP) |
|
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
|
1 | Q09750 (/IGI) |
|
Cerebral cortex neuron differentiation GO:0021895
The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.
|
1 | Q60520 (/IMP) |
|
Regulation of DNA-dependent DNA replication initiation GO:0030174
Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.
|
1 | P22579 (/IMP) |
|
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
|
1 | A0A1D8PCC3 (/IMP) |
|
Regulation of axon extension GO:0030516
Any process that modulates the rate, direction or extent of axon extension.
|
1 | Q60520 (/IMP) |
|
Chromatin silencing at centromere GO:0030702
Repression of transcription of centromeric DNA by altering the structure of chromatin.
|
1 | Q09750 (/IMP) |
|
Positive regulation of chromatin silencing GO:0031937
Any process that activates or increases the frequency, rate or extent of chromatin silencing.
|
1 | Q60520 (/ISO) |
|
Negative regulation of chromatin silencing at telomere GO:0031939
Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres.
|
1 | P22579 (/IMP) |
|
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
|
1 | Q60520 (/IMP) |
|
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
|
1 | A0A1D8PCC3 (/IMP) |
|
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
|
1 | A0A1D8PCC3 (/IMP) |
|
Swimming behavior GO:0036269
The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.
|
1 | Q1LYM8 (/IMP) |
|
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
|
1 | Q60520 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q60520 (/IMP) |
|
Regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0043619
Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q60520 (/ISO) |
|
Ossification involved in bone maturation GO:0043931
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.
|
1 | Q1LYM8 (/IMP) |
|
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
|
1 | Q60520 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q60520 (/ISO) |
|
Negative regulation of transcription involved in meiotic cell cycle GO:0051038
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle.
|
1 | P22579 (/IMP) |
|
Response to methylglyoxal GO:0051595
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.
|
1 | Q60520 (/IDA) |
|
Negative regulation of chromatin silencing at silent mating-type cassette GO:0061186
Any process that decreases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin.
|
1 | P22579 (/IMP) |
|
Negative regulation of chromatin silencing at rDNA GO:0061188
Any process that decreases the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin.
|
1 | P22579 (/IMP) |
|
Positive regulation of transcription from RNA polymerase II promoter in response to heat stress GO:0061408
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
1 | P22579 (/IMP) |
|
Transfer RNA gene-mediated silencing GO:0061587
The chromatin silencing that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes.
|
1 | P22579 (/IMP) |
|
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
1 | Q60520 (/IDA) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
1 | A0A0B4K765 (/IGI) |
|
Negative regulation of protein localization to nucleus GO:1900181
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.
|
1 | Q60520 (/ISO) |
|
Negative regulation of histone H3-K27 acetylation GO:1901675
Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 acetylation.
|
1 | Q60520 (/ISO) |
|
Negative regulation of transcription regulatory region DNA binding GO:2000678
Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.
|
1 | Q60520 (/ISO) |
There are 33 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
17 |
A0A0B4K765 (/IDA)
A0A0B4LF82 (/IDA)
A0A0B4LF93 (/IDA)
A0A126GUN9 (/IDA)
A1Z927 (/IDA)
A1Z928 (/IDA)
O13919 (/IDA)
O17142 (/IDA)
O17143 (/IDA)
O77025 (/IDA)
(7 more) |
|
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
12 |
A0A0B4K765 (/IDA)
A0A0B4LF82 (/IDA)
A0A0B4LF93 (/IDA)
A0A0G2K3H5 (/IDA)
A0A126GUN9 (/IDA)
A1Z927 (/IDA)
A1Z928 (/IDA)
D3ZBP2 (/IDA)
O17142 (/IDA)
O17143 (/IDA)
(2 more) |
|
Sin3 complex GO:0016580
A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
|
12 |
A0A0B4K765 (/NAS)
A0A0B4LF82 (/NAS)
A0A0B4LF93 (/NAS)
A0A126GUN9 (/NAS)
A1Z927 (/NAS)
A1Z928 (/NAS)
O17142 (/NAS)
O17143 (/NAS)
O77025 (/NAS)
Q5U0Y0 (/NAS)
(2 more) |
|
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
|
11 |
A0A0B4K765 (/IDA)
A0A0B4LF82 (/IDA)
A0A0B4LF93 (/IDA)
A0A126GUN9 (/IDA)
A1Z927 (/IDA)
A1Z928 (/IDA)
O17142 (/IDA)
O17143 (/IDA)
O77025 (/IDA)
Q5U0Y0 (/IDA)
(1 more) |
|
Sin3-type complex GO:0070822
Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.
|
11 |
A0A0B4K765 (/IDA)
A0A0B4LF82 (/IDA)
A0A0B4LF93 (/IDA)
A0A126GUN9 (/IDA)
A1Z927 (/IDA)
A1Z928 (/IDA)
O17142 (/IDA)
O17143 (/IDA)
O77025 (/IDA)
P22579 (/IDA)
(1 more) |
|
Euchromatin GO:0000791
A dispersed and relatively uncompacted form of chromatin.
|
10 | A0A0B4K765 (/TAS) A0A0B4LF82 (/TAS) A0A0B4LF93 (/TAS) A0A126GUN9 (/TAS) A1Z927 (/TAS) A1Z928 (/TAS) O17142 (/TAS) O17143 (/TAS) O77025 (/TAS) Q5U0Y0 (/TAS) |
|
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
|
10 | A0A0B4K765 (/IDA) A0A0B4LF82 (/IDA) A0A0B4LF93 (/IDA) A0A126GUN9 (/IDA) A1Z927 (/IDA) A1Z928 (/IDA) O17142 (/IDA) O17143 (/IDA) O77025 (/IDA) Q5U0Y0 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
5 | D3ZBP2 (/TAS) O75182 (/TAS) Q60520 (/TAS) Q96ST3 (/TAS) Q96ST3 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O75182 (/ISS) Q96ST3 (/ISS) Q96ST3 (/ISS) |
|
Rpd3S complex GO:0032221
A eukaryotically conserved histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species).
|
3 | O13919 (/IDA) P22579 (/IDA) Q09750 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q96ST3 (/IDA) Q96ST3 (/IDA) |
|
Sin3 complex GO:0016580
A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
|
2 | Q96ST3 (/IDA) Q96ST3 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
2 | A0A0G2K3H5 (/IDA) D3ZBP2 (/IDA) |
|
Rpd3L complex GO:0033698
A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae).
|
2 | P22579 (/IDA) Q09750 (/IDA) |
|
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
|
1 | Q60520 (/IDA) |
|
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
1 | Q60520 (/ISO) |
|
X chromosome GO:0000805
The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.
|
1 | Q62141 (/IDA) |
|
Y chromosome GO:0000806
The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.
|
1 | Q62141 (/IDA) |
|
XY body GO:0001741
A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.
|
1 | Q62141 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O13919 (/HDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q60520 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q60520 (/ISO) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | Q60520 (/IPI) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q62141 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9LFQ3 (/IDA) |
|
Sin3 complex GO:0016580
A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.
|
1 | Q60520 (/ISO) |
|
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
|
1 | Q60520 (/IPI) |
|
Autosome GO:0030849
Any chromosome other than a sex chromosome.
|
1 | Q62141 (/IDA) |
|
Nuclear pericentric heterochromatin GO:0031618
Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
|
1 | Q09750 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q60520 (/ISO) |
|
Rpd3L complex GO:0033698
A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae).
|
1 | P22579 (/HDA) |
|
Rpd3L-Expanded complex GO:0070210
A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.
|
1 | P22579 (/HDA) |
|
Clr6 histone deacetylase complex I'' GO:1990483
A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3.
|
1 | Q09750 (/IPI) |
