The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
VPS9 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: GTPase-activating protein and VPS9 domain-containi...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
6 A2RV61 (/ISS) A5D794 (/ISS) A8WVM4 (/ISS) Q29HW3 (/ISS) Q9GYH7 (/ISS) Q9VZ08 (/ISS)
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
6 A2RV61 (/ISS) A5D794 (/ISS) A8WVM4 (/ISS) Q29HW3 (/ISS) Q9GYH7 (/ISS) Q9VZ08 (/ISS)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
3 Q14C86 (/IMP) Q14C86 (/IMP) Q6PAR5 (/IMP)
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
3 Q14C86 (/IMP) Q14C86 (/IMP) Q6PAR5 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q6PAR5 (/IPI) Q9GYH7 (/IPI)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
2 Q14C86 (/HDA) Q14C86 (/HDA)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q6PAR5 (/ISO)
Rab guanyl-nucleotide exchange factor activity GO:0017112
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q9VZ08 (/ISM)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 Q9GYH7 (/IPI)
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
1 Q6PAR5 (/ISO)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of protein transport GO:0051223
Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 A2RV61 (/ISS) A5D794 (/ISS) A8WVM4 (/ISS) Q29HW3 (/ISS) Q9GYH7 (/ISS) Q9VZ08 (/ISS)
Regulation of protein transport GO:0051223
Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 Q14C86 (/IMP) Q14C86 (/IMP) Q6PAR5 (/IMP)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
2 Q14C86 (/TAS) Q14C86 (/TAS)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 Q9GYH7 (/IMP)
Molting cycle, collagen and cuticulin-based cuticle GO:0018996
The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans.
1 Q9GYH7 (/IGI)
Aggregation involved in sorocarp development GO:0031152
The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
1 Q55AA6 (/IMP)
Regulation of Rab protein signal transduction GO:0032483
Any process that modulates the frequency, rate or extent of Rab protein signal transduction.
1 Q9VZ08 (/ISM)
Chemotaxis to folate GO:0043326
The directed movement of a motile cell or organism in response to the presence of folate.
1 Q55AA6 (/IMP)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 Q9GYH7 (/IGI)
Regulation of protein transport GO:0051223
Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q6PAR5 (/ISO)
Regulation of clathrin-dependent endocytosis GO:2000369
Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis.
1 Q9GYH7 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
15 A0A024R862 (/IDA) A0A024R862 (/IDA) A0A024R862 (/IDA) A0A024R875 (/IDA) A0A024R875 (/IDA) A0A024R875 (/IDA) A0A024R8A2 (/IDA) A0A024R8A2 (/IDA) A0A024R8A2 (/IDA) F8W9S7 (/IDA)
(5 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 A2RV61 (/ISS) A5D794 (/ISS) A8WVM4 (/ISS) Q29HW3 (/ISS) Q9GYH7 (/ISS) Q9VZ08 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q14C86 (/TAS) Q14C86 (/TAS)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q9GYH7 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6PAR5 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9GYH7 (/IDA)
Clathrin-coated endocytic vesicle GO:0045334
A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.
1 Q9GYH7 (/IDA)
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