The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Transcription factor, Skn-1-like, DNA-binding domain
".
FunFam 1: Nuclear factor erythroid 2-related factor 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 40 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
12 |
O54968 (/IPI)
Q07279 (/IPI)
Q14494 (/IPI)
Q14494 (/IPI)
Q14494 (/IPI)
Q16236 (/IPI)
Q16621 (/IPI)
Q16621 (/IPI)
Q16621 (/IPI)
Q60795 (/IPI)
(2 more) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
8 | A7YYH1 (/IDA) Q16236 (/IDA) Q16621 (/IDA) Q16621 (/IDA) Q16621 (/IDA) Q60795 (/IDA) Q7ZVI2 (/IDA) Q8JIM1 (/IDA) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | Q14494 (/ISA) Q14494 (/ISA) Q14494 (/ISA) Q16236 (/ISA) Q16621 (/ISA) Q16621 (/ISA) Q16621 (/ISA) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | Q14494 (/ISM) Q14494 (/ISM) Q14494 (/ISM) Q16236 (/ISM) Q16621 (/ISM) Q16621 (/ISM) Q16621 (/ISM) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | Q14494 (/NAS) Q14494 (/NAS) Q14494 (/NAS) Q16236 (/NAS) Q16621 (/NAS) Q16621 (/NAS) Q16621 (/NAS) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
7 | Q14494 (/TAS) Q14494 (/TAS) Q14494 (/TAS) Q16236 (/TAS) Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
7 | A7YYH1 (/IPI) B3DG00 (/IPI) B3DGX1 (/IPI) F1QWY1 (/IPI) Q7ZVI2 (/IPI) Q7ZZR2 (/IPI) Q8JIM1 (/IPI) |
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
4 | A7YYH1 (/IDA) O54968 (/IDA) Q7ZVI2 (/IDA) Q8JIM1 (/IDA) |
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
|
3 | Q60795 (/IDA) Q61985 (/IDA) Q61985 (/IDA) |
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | Q16621 (/IDA) Q16621 (/IDA) Q16621 (/IDA) |
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | Q60795 (/IDA) Q61985 (/IDA) Q61985 (/IDA) |
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
3 | Q14494 (/TAS) Q14494 (/TAS) Q14494 (/TAS) |
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
3 | Q16236 (/IPI) Q61985 (/IPI) Q61985 (/IPI) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
3 | Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
3 | Q16621 (/IPI) Q16621 (/IPI) Q16621 (/IPI) |
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
|
3 | Q16621 (/IDA) Q16621 (/IDA) Q16621 (/IDA) |
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
|
3 | Q16621 (/IPI) Q16621 (/IPI) Q16621 (/IPI) |
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q07279 (/ISO) Q60795 (/ISO) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | Q61985 (/IDA) Q61985 (/IDA) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | Q16236 (/IDA) Q60795 (/IDA) |
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
2 | Q61985 (/IDA) Q61985 (/IDA) |
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
2 | Q61985 (/IDA) Q61985 (/IDA) |
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
2 | Q61985 (/IDA) Q61985 (/IDA) |
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
1 | Q60795 (/ISO) |
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
|
1 | Q16236 (/TAS) |
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q07279 (/ISO) |
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
1 | Q16236 (/IPI) |
RNA polymerase II activating transcription factor binding GO:0001102
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.
|
1 | Q60795 (/ISO) |
Transcription cofactor binding GO:0001221
Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
|
1 | O54968 (/IPI) |
Transcription cofactor binding GO:0001221
Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
|
1 | Q60795 (/ISO) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | Q60795 (/ISO) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | Q60795 (/IPI) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q60795 (/ISO) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | O54968 (/IDA) |
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | Q60795 (/ISO) |
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
1 | Q16236 (/TAS) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q60795 (/TAS) |
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q07279 (/ISO) |
WW domain binding GO:0050699
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
|
1 | Q07279 (/ISO) |
There are 137 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | B3DG00 (/IC) B3DGX1 (/IC) F1QWY1 (/IC) Q7ZZR2 (/IC) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | A7YYH1 (/IDA) Q60795 (/IDA) Q7ZVI2 (/IDA) Q8JIM1 (/IDA) |
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
4 | Q14494 (/TAS) Q14494 (/TAS) Q14494 (/TAS) Q16236 (/TAS) |
Regulation of primitive erythrocyte differentiation GO:0010725
Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis.
|
4 | B3DG00 (/IMP) B3DGX1 (/IMP) F1QWY1 (/IMP) Q7ZZR2 (/IMP) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
4 | A7YYH1 (/IMP) Q60795 (/IMP) Q7ZVI2 (/IMP) Q8JIM1 (/IMP) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | A7YYH1 (/IGI) Q60795 (/IGI) Q7ZVI2 (/IGI) Q8JIM1 (/IGI) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
4 | Q16236 (/IDA) Q60795 (/IDA) Q61985 (/IDA) Q61985 (/IDA) |
Swim bladder inflation GO:0048798
The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ.
|
4 | B3DG00 (/IMP) B3DGX1 (/IMP) F1QWY1 (/IMP) Q7ZZR2 (/IMP) |
Otic vesicle morphogenesis GO:0071600
The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear.
|
4 | B3DG00 (/IMP) B3DGX1 (/IMP) F1QWY1 (/IMP) Q7ZZR2 (/IMP) |
Regulation of response to oxidative stress GO:1902882
Any process that modulates the frequency, rate or extent of response to oxidative stress.
|
4 | B3DG00 (/IMP) B3DGX1 (/IMP) F1QWY1 (/IMP) Q7ZZR2 (/IMP) |
Nucleosome disassembly GO:0006337
The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
|
3 | Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | A7YYH1 (/IMP) Q7ZVI2 (/IMP) Q8JIM1 (/IMP) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Heme biosynthetic process GO:0006783
The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
|
3 | Q14494 (/TAS) Q14494 (/TAS) Q14494 (/TAS) |
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
3 | Q14494 (/TAS) Q14494 (/TAS) Q14494 (/TAS) |
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
3 | A7YYH1 (/IMP) Q7ZVI2 (/IMP) Q8JIM1 (/IMP) |
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
3 | Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
|
3 | Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Hemostasis GO:0007599
The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.
|
3 | Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
|
3 | Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
|
3 | Q14494 (/TAS) Q14494 (/TAS) Q14494 (/TAS) |
Proteasomal ubiquitin-independent protein catabolic process GO:0010499
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin.
|
3 | O54968 (/ISS) Q5NUA6 (/ISS) Q60795 (/ISS) |
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
3 | O54968 (/ISS) Q5NUA6 (/ISS) Q60795 (/ISS) |
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
|
3 | Q60795 (/IMP) Q61985 (/IMP) Q61985 (/IMP) |
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
3 | O54968 (/ISS) Q5NUA6 (/ISS) Q60795 (/ISS) |
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
|
3 | O54968 (/ISS) Q5NUA6 (/ISS) Q60795 (/ISS) |
Regulation of megakaryocyte differentiation GO:0045652
Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
|
3 | Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Regulation of transcription from RNA polymerase II promoter in response to copper ion GO:0061396
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus.
|
3 | Q60795 (/IMP) Q61985 (/IMP) Q61985 (/IMP) |
Cellular response to prostaglandin stimulus GO:0071379
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus.
|
3 | A7YYH1 (/IGI) Q7ZVI2 (/IGI) Q8JIM1 (/IGI) |
Cellular response to prostaglandin stimulus GO:0071379
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus.
|
3 | A7YYH1 (/IMP) Q7ZVI2 (/IMP) Q8JIM1 (/IMP) |
Cellular response to xenobiotic stimulus GO:0071466
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
|
3 | A7YYH1 (/IGI) Q7ZVI2 (/IGI) Q8JIM1 (/IGI) |
Cellular response to xenobiotic stimulus GO:0071466
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
|
3 | A7YYH1 (/IMP) Q7ZVI2 (/IMP) Q8JIM1 (/IMP) |
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
|
3 | O54968 (/ISS) Q5NUA6 (/ISS) Q60795 (/ISS) |
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Fructose 6-phosphate metabolic process GO:0006002
The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q61985 (/IDA) Q61985 (/IDA) |
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Glutathione metabolic process GO:0006749
The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Regulation of mitotic nuclear division GO:0007088
Any process that modulates the frequency, rate or extent of mitosis.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q16236 (/IGI) Q60795 (/IGI) |
Regulation of glucose metabolic process GO:0010906
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Regulation of fatty acid metabolic process GO:0019217
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Spinal cord motor neuron differentiation GO:0021522
The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Glial cell fate commitment GO:0021781
The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell.
|
2 | Q61985 (/IDA) Q61985 (/IDA) |
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
|
2 | Q61985 (/IDA) Q61985 (/IDA) |
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Cysteine transport GO:0042883
The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
|
2 | Q16236 (/IMP) Q60795 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q16236 (/IMP) Q60795 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | O54968 (/ISS) Q5NUA6 (/ISS) |
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Glucose 6-phosphate metabolic process GO:0051156
The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Regulation of proteasomal protein catabolic process GO:0061136
Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Cellular response to cold GO:0070417
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Cellular response to cholesterol GO:0071397
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Regulation of nucleus organization GO:1903353
Any process that modulates the frequency, rate or extent of nucleus organization.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Regulation of response to endoplasmic reticulum stress GO:1905897
Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress.
|
2 | Q61985 (/IMP) Q61985 (/IMP) |
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | Q60795 (/IMP) |
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
|
1 | Q07279 (/IMP) |
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | O54968 (/IEP) |
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | Q07279 (/IDA) |
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q07279 (/IDA) |
Proteasomal ubiquitin-independent protein catabolic process GO:0010499
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin.
|
1 | Q16236 (/IDA) |
Proteasomal ubiquitin-independent protein catabolic process GO:0010499
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin.
|
1 | Q60795 (/ISO) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q60795 (/ISO) |
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
|
1 | O54968 (/IMP) |
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
|
1 | Q60795 (/ISO) |
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | O54968 (/IMP) |
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | Q60795 (/ISO) |
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | Q16236 (/IDA) |
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | Q60795 (/ISO) |
Positive regulation of blood coagulation GO:0030194
Any process that activates or increases the frequency, rate or extent of blood coagulation.
|
1 | Q60795 (/IMP) |
Negative regulation of bone mineralization GO:0030502
Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.
|
1 | Q07279 (/IMP) |
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
|
1 | Q60795 (/IDA) |
Endoplasmic reticulum unfolded protein response GO:0030968
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
|
1 | Q16236 (/ISS) |
Negative regulation of syncytium formation by plasma membrane fusion GO:0034242
Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
|
1 | Q07279 (/IGI) |
Negative regulation of syncytium formation by plasma membrane fusion GO:0034242
Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
|
1 | Q07279 (/IMP) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q60795 (/IDA) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q16236 (/NAS) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q16236 (/TAS) |
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | Q60795 (/IMP) |
Positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
1 | Q16236 (/IMP) |
Positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
1 | Q60795 (/ISO) |
Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0036091
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | O54968 (/IMP) |
Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress GO:0036091
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q60795 (/ISO) |
PERK-mediated unfolded protein response GO:0036499
A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
|
1 | Q60795 (/IDA) |
PERK-mediated unfolded protein response GO:0036499
A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
|
1 | Q16236 (/ISS) |
PERK-mediated unfolded protein response GO:0036499
A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.
|
1 | Q16236 (/TAS) |
Cellular response to glucose starvation GO:0042149
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
|
1 | Q60795 (/IMP) |
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | Q16236 (/IDA) |
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | Q60795 (/ISO) |
Positive regulation of blood vessel endothelial cell migration GO:0043536
Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
|
1 | O54968 (/IMP) |
Positive regulation of blood vessel endothelial cell migration GO:0043536
Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
|
1 | Q60795 (/ISO) |
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
|
1 | Q60795 (/ISO) |
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
1 | O54968 (/IMP) |
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
1 | Q60795 (/ISO) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q60795 (/IDA) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q16236 (/IC) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q60795 (/ISO) |
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
|
1 | Q60795 (/IGI) |
Aflatoxin catabolic process GO:0046223
The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
|
1 | O54968 (/IMP) |
Aflatoxin catabolic process GO:0046223
The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
|
1 | Q60795 (/ISO) |
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
|
1 | Q60795 (/IDA) |
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
|
1 | O54968 (/IMP) |
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
|
1 | Q60795 (/ISO) |
Labyrinthine layer blood vessel development GO:0060716
The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.
|
1 | Q07279 (/IMP) |
Positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
|
1 | Q16236 (/IMP) |
Positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.
|
1 | Q60795 (/ISO) |
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | Q16236 (/IMP) |
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | Q60795 (/ISO) |
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | Q16236 (/IMP) |
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | Q60795 (/ISO) |
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | O54968 (/IEP) |
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
|
1 | Q16236 (/IDA) |
Cellular response to fluid shear stress GO:0071498
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
|
1 | Q60795 (/ISO) |
Cellular response to laminar fluid shear stress GO:0071499
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers.
|
1 | Q16236 (/IMP) |
Cellular response to laminar fluid shear stress GO:0071499
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers.
|
1 | Q60795 (/ISO) |
Negative regulation of hematopoietic stem cell differentiation GO:1902037
Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation.
|
1 | Q60795 (/IMP) |
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176
Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.
|
1 | Q16236 (/IMP) |
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176
Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.
|
1 | Q60795 (/ISO) |
Positive regulation of ER-associated ubiquitin-dependent protein catabolic process GO:1903071
Any process that activates or increases the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process.
|
1 | Q16236 (/TAS) |
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
|
1 | Q16236 (/IGI) |
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
|
1 | Q60795 (/ISO) |
Positive regulation of glutathione biosynthetic process GO:1903788
Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process.
|
1 | Q60795 (/IMP) |
Cellular response to angiotensin GO:1904385
\Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.\
|
1 | O54968 (/IEP) |
Negative regulation of vascular associated smooth muscle cell migration GO:1904753
Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.
|
1 | O54968 (/IMP) |
Negative regulation of vascular associated smooth muscle cell migration GO:1904753
Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.
|
1 | Q60795 (/ISO) |
Regulation of removal of superoxide radicals GO:2000121
Any process that modulates the frequency, rate or extent of removal of superoxide radicals.
|
1 | Q60795 (/IMP) |
Negative regulation of endothelial cell apoptotic process GO:2000352
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.
|
1 | Q16236 (/IMP) |
Negative regulation of endothelial cell apoptotic process GO:2000352
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.
|
1 | Q60795 (/ISO) |
Positive regulation of reactive oxygen species metabolic process GO:2000379
Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
|
1 | Q60795 (/IMP) |
Positive regulation of peptidyl-lysine acetylation GO:2000758
Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation.
|
1 | Q07279 (/IMP) |
There are 28 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
22 |
A7YYH1 (/IDA)
B4DYE1 (/IDA)
B4DYE1 (/IDA)
B4DYE1 (/IDA)
F5H1B7 (/IDA)
F5H1B7 (/IDA)
F5H1B7 (/IDA)
F5H1B7 (/IDA)
J3QKY3 (/IDA)
J3QKY3 (/IDA)
(12 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
18 |
B4DYE1 (/IDA)
B4DYE1 (/IDA)
B4DYE1 (/IDA)
C9JBM0 (/IDA)
F5H1B7 (/IDA)
F5H1B7 (/IDA)
F5H1B7 (/IDA)
F5H1B7 (/IDA)
J3QKY3 (/IDA)
J3QKY3 (/IDA)
(8 more) |
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
7 | A7YYH1 (/IDA) B3DG00 (/IDA) B3DGX1 (/IDA) F1QWY1 (/IDA) Q7ZVI2 (/IDA) Q7ZZR2 (/IDA) Q8JIM1 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | A7YYH1 (/IDA) O54968 (/IDA) Q16236 (/IDA) Q60795 (/IDA) Q7ZVI2 (/IDA) Q8JIM1 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | B3DG00 (/IC) B3DGX1 (/IC) F1QWY1 (/IC) Q7ZZR2 (/IC) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | Q07279 (/TAS) Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
4 | Q16621 (/IDA) Q16621 (/IDA) Q16621 (/IDA) Q60795 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q60795 (/ISO) Q61985 (/ISO) Q61985 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q16621 (/TAS) Q16621 (/TAS) Q16621 (/TAS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q60795 (/ISO) Q61985 (/ISO) Q61985 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | C9JBM0 (/IDA) Q16236 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | Q61985 (/IDA) Q61985 (/IDA) |
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
2 | Q61985 (/IDA) Q61985 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
2 | C9JBM0 (/IDA) Q16236 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | C9JBM0 (/IDA) Q16236 (/IDA) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
2 | Q61985 (/IDA) Q61985 (/IDA) |
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
1 | Q60795 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q5NUA6 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q60795 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q60795 (/IPI) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q60795 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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1 | Q5NUA6 (/ISS) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
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1 | Q60795 (/ISO) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
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1 | Q16236 (/IDA) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
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1 | Q60795 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
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1 | Q60795 (/ISO) |
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
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1 | Q07279 (/ISO) |
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
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1 | Q16236 (/ISS) |