The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Helical domain of apoptotic protease-activating factors
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Disease resistance protein (TIR-NBS-LRR class)

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 F4I901 (/IPI) F4JNA9 (/IPI) F4JNB7 (/IPI) F4JWM0 (/IPI) F4KHI3 (/IPI) F4KHI3 (/IPI) O23530 (/IPI) Q9FHF0 (/IPI) Q9SZ66 (/IPI) Q9XGM3 (/IPI)
LRR domain binding GO:0030275
Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein.
2 F4J339 (/ISS) F4JNA9 (/ISS)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
1 O23530 (/ISS)
Nucleotide binding GO:0000166
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
1 F4JNB7 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9XGM3 (/IPI)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
6 F4JWM0 (/IMP) F4KHH8 (/IMP) O23530 (/IMP) Q9FHF0 (/IMP) Q9FI14 (/IMP) Q9SZ66 (/IMP)
Defense response to fungus, incompatible interaction GO:0009817
A response of an organism to a fungus that prevents the occurrence or spread of disease.
4 F4J339 (/IMP) F4JNB7 (/IMP) Q9C7X0 (/IMP) Q9FT77 (/IMP)
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
3 F4J339 (/TAS) F4JNA9 (/TAS) F4JNB7 (/TAS)
Plant-type hypersensitive response GO:0009626
The rapid, localized death of plant cells in response to invasion by a pathogen.
3 O48573 (/IMP) O48573 (/IMP) Q9XGM3 (/IMP)
Defense response signaling pathway, resistance gene-dependent GO:0009870
A series of molecular signals that depends upon R-genes and is activated during defense response.
3 O49471 (/IDA) Q9FHF0 (/IDA) Q9XGM3 (/IDA)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 O48573 (/IMP) O48573 (/IMP)
Regulation of root meristem growth GO:0010082
Any process involved in maintaining the size and shape of a root meristem.
2 F4KHI3 (/IMP) F4KHI3 (/IMP)
Defense response to fungus GO:0050832
Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
2 F4I594 (/IMP) Q9CAK1 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 O48573 (/IMP) O48573 (/IMP)
Defense response to oomycetes GO:0002229
Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism.
1 Q9C7X0 (/IMP)
Response to oomycetes GO:0002239
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes.
1 F4J339 (/IDA)
Response to auxin GO:0009733
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
1 O23530 (/IGI)
Defense response to bacterium, incompatible interaction GO:0009816
A response of an organism to a bacterium that prevents the occurrence or spread of disease.
1 Q9FI14 (/IMP)
Defense response to fungus, incompatible interaction GO:0009817
A response of an organism to a fungus that prevents the occurrence or spread of disease.
1 F4JNA9 (/ISS)
Defense response to fungus, incompatible interaction GO:0009817
A response of an organism to a fungus that prevents the occurrence or spread of disease.
1 F4J339 (/TAS)
Systemic acquired resistance, salicylic acid mediated signaling pathway GO:0009862
The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance.
1 O23530 (/IMP)
Response to ozone GO:0010193
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus.
1 O82500 (/IEP)
Cellular response to UV GO:0034644
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
1 Q9C7X0 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q9XGM3 (/IDA)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 O23530 (/IGI)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 F4J361 (/ISS)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 F4I901 (/IGI)
Regulation of cellular response to stress GO:0080135
Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
1 Q9LFN1 (/IMP)
Regulation of defense response by callose deposition GO:2000071
Any process that modulates the frequency, rate or extent of defense response by callose deposition.
1 Q9FT77 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 F4I901 (/IDA) F4KHI3 (/IDA) F4KHI3 (/IDA) O23530 (/IDA) Q9XGM3 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 F4KHI3 (/IDA) F4KHI3 (/IDA) O23530 (/IDA) Q9FKB9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 F4I901 (/IDA) O23530 (/IDA) Q9C7X0 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 F4JNB6 (/IDA) O82500 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 F4J339 (/IDA) F4KFY5 (/IDA)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 F4J339 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 F4J339 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 F4I9F1 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q9M0P9 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 F4KFY5 (/IDA)
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
1 Q9XGM3 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9SCZ2 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9XGM3 (/ISS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 O23530 (/IDA)
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