The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Retinoid X Receptor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Nuclear receptor subfamily 4 group A member 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 48 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
47 F1D8N6 (/IPI) F1D8N6 (/IPI) F1D8N6 (/IPI) F1D8N6 (/IPI) F1D8N6 (/IPI) F1D8N6 (/IPI) F1D8N6 (/IPI) F1D8N6 (/IPI) F1D8N6 (/IPI) F1D8N6 (/IPI)
(37 more)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
25 P22736 (/TAS) P22736 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS)
(15 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
25 P22736 (/ISS) P22736 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS)
(15 more)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
24 P22736 (/ISS) P22736 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS)
(14 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 P22736 (/ISA) P22736 (/ISA) P43354 (/ISA) P43354 (/ISA) P43354 (/ISA) P43354 (/ISA) P43354 (/ISA) P43354 (/ISA) P43354 (/ISA) P43354 (/ISA)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 P22736 (/ISM) P22736 (/ISM) P43354 (/ISM) P43354 (/ISM) P43354 (/ISM) P43354 (/ISM) P43354 (/ISM) P43354 (/ISM) P43354 (/ISM) P43354 (/ISM)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 P22736 (/NAS) P22736 (/NAS) P43354 (/NAS) P43354 (/NAS) P43354 (/NAS) P43354 (/NAS) P43354 (/NAS) P43354 (/NAS) P43354 (/NAS) P43354 (/NAS)
(12 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
21 P22736 (/TAS) P22736 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS)
(11 more)
Beta-catenin binding GO:0008013
Interacting selectively and non-covalently with the beta subunit of the catenin complex.
18 P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS)
(8 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
18 P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS)
(8 more)
Showing 1 to 10 of 48 entries

There are 151 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
29 P22736 (/ISS) P22736 (/ISS) P22829 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS)
(19 more)
Cellular response to corticotropin-releasing hormone stimulus GO:0071376
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response.
29 P22736 (/ISS) P22736 (/ISS) P22829 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS)
(19 more)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
23 P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS)
(13 more)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
22 P22736 (/TAS) P22736 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS)
(12 more)
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
21 P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS) P43354 (/ISS)
(11 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
20 P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA)
(10 more)
Cellular response to extracellular stimulus GO:0031668
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.
20 P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA) P43354 (/IDA)
(10 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
18 P43354 (/IMP) P43354 (/IMP) P43354 (/IMP) P43354 (/IMP) P43354 (/IMP) P43354 (/IMP) P43354 (/IMP) P43354 (/IMP) P43354 (/IMP) P43354 (/IMP)
(8 more)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
18 P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS)
(8 more)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
18 P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS)
(8 more)
Showing 1 to 10 of 151 entries

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
36 F1D8N6 (/IDA) F1D8N6 (/IDA) F1D8N6 (/IDA) F1D8N6 (/IDA) F1D8N6 (/IDA) F1D8N6 (/IDA) F1D8N6 (/IDA) F1D8N6 (/IDA) F1D8N6 (/IDA) F1D8N6 (/IDA)
(26 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
29 A0A024R126 (/IDA) A0A024R126 (/IDA) F5GXF0 (/IDA) P12813 (/IDA) P12813 (/IDA) P22736 (/IDA) P22736 (/IDA) P22829 (/IDA) P43354 (/IDA) P43354 (/IDA)
(19 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
24 P22736 (/TAS) P22736 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS)
(14 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
18 P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS) P43354 (/TAS)
(8 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P22736 (/ISS) P22736 (/ISS) P49869 (/ISS) Q08E53 (/ISS) Q5R5Y4 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 A0A024R126 (/IDA) A0A024R126 (/IDA) F5GXF0 (/IDA) P22736 (/IDA) P22736 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
5 A0A024R126 (/IDA) A0A024R126 (/IDA) F5GXF0 (/IDA) P22736 (/IDA) P22736 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P12813 (/ISO) P12813 (/ISO) Q06219 (/ISO) Q06219 (/ISO)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
3 P12813 (/IDA) P12813 (/IDA) Q9QZB6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q92570 (/NAS) Q92570 (/NAS)
Showing 1 to 10 of 17 entries
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