The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Retinoid X Receptor
".
FunFam 16: Nuclear receptor subfamily 1 group D member 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 36 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
8 | P20393 (/IPI) P20393 (/IPI) P20393 (/IPI) Q14995 (/IPI) Q3UV55 (/IPI) Q60674 (/IPI) Q60674 (/IPI) Q63503 (/IPI) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
7 | F1RAU6 (/IDA) P20393 (/IDA) P20393 (/IDA) P20393 (/IDA) Q60674 (/IDA) Q60674 (/IDA) Q6TNS3 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
4 | P20393 (/IDA) P20393 (/IDA) P20393 (/IDA) Q14995 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
4 | P20393 (/ISA) P20393 (/ISA) P20393 (/ISA) Q14995 (/ISA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
4 | P20393 (/ISM) P20393 (/ISM) P20393 (/ISM) Q14995 (/ISM) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
4 | P20393 (/NAS) P20393 (/NAS) P20393 (/NAS) Q14995 (/NAS) |
|
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
|
4 | B3SV56 (/ISS) Q08E02 (/ISS) Q3UV55 (/ISS) Q63503 (/ISS) |
|
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
|
4 | P20393 (/TAS) P20393 (/TAS) P20393 (/TAS) Q14995 (/TAS) |
|
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
|
3 | P20393 (/IDA) P20393 (/IDA) P20393 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | P20393 (/IMP) P20393 (/IMP) P20393 (/IMP) |
Showing 1 to 10 of 36 entries
There are 90 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
|
8 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q14995 (/ISS) Q63503 (/ISS) Q63504 (/ISS) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
7 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q14995 (/ISS) Q63504 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
7 | P20393 (/IDA) P20393 (/IDA) P20393 (/IDA) Q14995 (/IDA) Q3UV55 (/IDA) Q60674 (/IDA) Q60674 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
7 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q14995 (/ISS) Q63504 (/ISS) |
|
Glycogen biosynthetic process GO:0005978
The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
|
6 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS) |
|
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
|
6 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS) |
|
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
|
6 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
6 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS) |
|
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
6 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS) |
|
Regulation of circadian sleep/wake cycle GO:0042749
Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.
|
6 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS) |
Showing 1 to 10 of 90 entries
There are 22 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
9 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q60674 (/ISS) Q60674 (/ISS) Q63503 (/ISS) Q63504 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
8 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q14995 (/ISS) Q63503 (/ISS) Q63504 (/ISS) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
6 | F1D8S3 (/IDA) F1D8S3 (/IDA) F1D8S3 (/IDA) P20393 (/IDA) P20393 (/IDA) P20393 (/IDA) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
6 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS) |
|
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
6 | B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
5 | P20393 (/TAS) P20393 (/TAS) P20393 (/TAS) Q14995 (/TAS) Q3UV55 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q14995 (/IDA) Q3UV55 (/IDA) Q60674 (/IDA) Q60674 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | P20393 (/TAS) P20393 (/TAS) P20393 (/TAS) Q14995 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
4 | Q3UV55 (/IDA) Q60674 (/IDA) Q60674 (/IDA) Q63503 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
3 | P20393 (/IDA) P20393 (/IDA) P20393 (/IDA) |
Showing 1 to 10 of 22 entries
