The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Retinoid X Receptor
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Nuclear receptor subfamily 5, group A, member 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 41 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
15 B3DKN2 (/IDA) F1QKV6 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O42186 (/IDA) P33242 (/IDA) P45448 (/IDA)
(5 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
11 B3DKN2 (/IDA) F1QKV6 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O42186 (/IDA) Q08BE9 (/IDA) Q90YL6 (/IDA)
(1 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 O00482 (/IPI) O00482 (/IPI) O00482 (/IPI) O00482 (/IPI) O00482 (/IPI) O42186 (/IPI) P33242 (/IPI) Q04752 (/IPI) Q13285 (/IPI) Q13285 (/IPI)
(1 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
8 O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) P50569 (/IDA) Q13285 (/IDA) Q13285 (/IDA)
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
7 O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) Q13285 (/ISS) Q13285 (/ISS)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
7 O00482 (/ISA) O00482 (/ISA) O00482 (/ISA) O00482 (/ISA) O00482 (/ISA) Q13285 (/ISA) Q13285 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
7 O00482 (/ISM) O00482 (/ISM) O00482 (/ISM) O00482 (/ISM) O00482 (/ISM) Q13285 (/ISM) Q13285 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
7 O00482 (/NAS) O00482 (/NAS) O00482 (/NAS) O00482 (/NAS) O00482 (/NAS) Q13285 (/NAS) Q13285 (/NAS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
7 B3DKN2 (/NAS) F1QKV6 (/NAS) O42186 (/NAS) Q08BE9 (/NAS) Q800U8 (/NAS) Q90YL6 (/NAS) Q98ST8 (/NAS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
7 O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) Q13285 (/ISS) Q13285 (/ISS)
Showing 1 to 10 of 41 entries

There are 75 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
7 O00482 (/TAS) O00482 (/TAS) O00482 (/TAS) O00482 (/TAS) O00482 (/TAS) Q13285 (/TAS) Q13285 (/TAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
7 O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) P33242 (/IDA) P45448 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
7 O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) Q13285 (/ISS) Q13285 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
6 O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) P33242 (/IDA)
Sex determination GO:0007530
Any process that establishes and transmits the specification of sexual status of an individual organism.
6 P33242 (/ISS) P50569 (/ISS) P79387 (/ISS) Q04752 (/ISS) Q95L87 (/ISS) Q9GKL2 (/ISS)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
6 P33242 (/ISS) P50569 (/ISS) P79387 (/ISS) Q04752 (/ISS) Q95L87 (/ISS) Q9GKL2 (/ISS)
Female gonad development GO:0008585
The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
6 P33242 (/ISS) P50569 (/ISS) P79387 (/ISS) Q04752 (/ISS) Q95L87 (/ISS) Q9GKL2 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
5 O00482 (/TAS) O00482 (/TAS) O00482 (/TAS) O00482 (/TAS) O00482 (/TAS)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
5 O00482 (/TAS) O00482 (/TAS) O00482 (/TAS) O00482 (/TAS) O00482 (/TAS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
5 P50569 (/ISS) P79387 (/ISS) Q04752 (/ISS) Q95L87 (/ISS) Q9GKL2 (/ISS)
Showing 1 to 10 of 75 entries

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) P33242 (/IDA) P45448 (/IDA) P50569 (/IDA) Q13285 (/IDA) Q13285 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
7 O00482 (/TAS) O00482 (/TAS) O00482 (/TAS) O00482 (/TAS) O00482 (/TAS) Q13285 (/TAS) Q13285 (/TAS)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
7 O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) O00482 (/ISS) Q13285 (/ISS) Q13285 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA) O00482 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O42102 (/ISS) P79387 (/ISS) Q04752 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P33242 (/ISO) P45448 (/ISO)
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
2 P33242 (/IDA) P45448 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q04752 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P45448 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P45448 (/TAS)
Showing 1 to 10 of 10 entries
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