The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rho GTPase activation protein
".
FunFam 37: Phosphatidylinositol 3-kinase regulatory subunit b...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | O00459 (/IPI) O08908 (/IPI) P23726 (/IPI) |
|
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
|
1 | O00459 (/IPI) |
|
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
|
1 | O08908 (/ISO) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | O08908 (/IPI) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
1 | O00459 (/IPI) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
1 | O08908 (/ISO) |
|
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
1 | O00459 (/IPI) |
|
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
1 | O08908 (/ISO) |
|
Phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312
Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.
|
1 | O08908 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | O08908 (/IPI) |
Showing 1 to 10 of 11 entries
There are 34 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cellular glucose homeostasis GO:0001678
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
|
3 | O00459 (/ISS) P23726 (/ISS) Q63788 (/ISS) |
|
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
3 | O08908 (/ISS) P23726 (/ISS) Q63788 (/ISS) |
|
Phosphatidylinositol 3-kinase signaling GO:0014065
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
|
3 | O08908 (/ISS) P23726 (/ISS) Q63788 (/ISS) |
|
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
3 | O00459 (/ISS) P23726 (/ISS) Q63788 (/ISS) |
|
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
|
3 | O00459 (/ISS) P23726 (/ISS) Q63788 (/ISS) |
|
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
3 | O00459 (/ISS) P23726 (/ISS) Q63788 (/ISS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | O00459 (/ISS) P23726 (/ISS) Q63788 (/ISS) |
|
Cellular glucose homeostasis GO:0001678
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
|
1 | O08908 (/IDA) |
|
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
|
1 | O00459 (/TAS) |
|
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
|
1 | O08908 (/IMP) |
Showing 1 to 10 of 34 entries
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | O00459 (/ISS) P23726 (/ISS) Q63788 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | O00459 (/TAS) Q63788 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O08908 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | O08908 (/IDA) |
Showing 1 to 4 of 4 entries
