The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rho GTPase activation protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 34: Rac GTPase-activating protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
3 P40809 (/IDA) Q9H0H5 (/IDA) Q9H0H5 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
3 A1Z9I5 (/ISS) Q9N9Z9 (/ISS) Q9WVM1 (/ISS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
2 Q9H0H5 (/IMP) Q9H0H5 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9H0H5 (/IPI) Q9H0H5 (/IPI)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q9H0H5 (/IPI) Q9H0H5 (/IPI)
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Gamma-tubulin binding GO:0043015
Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q9WVM1 (/ISO)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
1 Q9WVM1 (/ISO)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
1 Q9WVM1 (/ISS)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 Q9WVM1 (/ISO)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
1 Q9WVM1 (/ISS)
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
1 P40809 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q9WVM1 (/ISO)
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
1 Q9WVM1 (/ISO)
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
1 Q9WVM1 (/ISS)
Gamma-tubulin binding GO:0043015
Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin.
1 Q9WVM1 (/ISO)
Gamma-tubulin binding GO:0043015
Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin.
1 Q9WVM1 (/ISS)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
1 Q9WVM1 (/ISO)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
1 Q9WVM1 (/ISS)

There are 48 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
6 A0A0R4IZK0 (/IMP) A1Z9I5 (/IMP) Q6P3H8 (/IMP) Q9H0H5 (/IMP) Q9H0H5 (/IMP) Q9N9Z9 (/IMP)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
2 A0A0R4IZK0 (/IMP) Q6P3H8 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Actomyosin contractile ring assembly GO:0000915
The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
2 Q9H0H5 (/IMP) Q9H0H5 (/IMP)
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890
The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
2 Q9H0H5 (/TAS) Q9H0H5 (/TAS)
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
2 Q9H0H5 (/TAS) Q9H0H5 (/TAS)
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
2 A1Z9I5 (/IGI) Q9N9Z9 (/IGI)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 Q9H0H5 (/IEP) Q9H0H5 (/IEP)
Neuroblast proliferation GO:0007405
The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
2 Q9H0H5 (/ISS) Q9H0H5 (/ISS)
Somatic muscle development GO:0007525
The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
2 A1Z9I5 (/IMP) Q9N9Z9 (/IMP)
Sulfate transport GO:0008272
The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 A1Z9I5 (/IGI) Q9N9Z9 (/IGI)
Antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.
2 Q9H0H5 (/TAS) Q9H0H5 (/TAS)
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
2 E2R3Q1 (/TAS) J9NSX3 (/TAS)
Regulation of cytokinesis GO:0032465
Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
2 A1Z9I5 (/IMP) Q9N9Z9 (/IMP)
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
2 Q9H0H5 (/IMP) Q9H0H5 (/IMP)
Maintenance of protein location in cell GO:0032507
Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.
2 A1Z9I5 (/IMP) Q9N9Z9 (/IMP)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
2 A1Z9I5 (/IMP) Q9N9Z9 (/IMP)
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
2 Q9H0H5 (/ISS) Q9H0H5 (/ISS)
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
2 A1Z9I5 (/IMP) Q9N9Z9 (/IMP)
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
2 Q9H0H5 (/TAS) Q9H0H5 (/TAS)
Mitotic spindle midzone assembly GO:0051256
The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Regulation of attachment of spindle microtubules to kinetochore GO:0051988
Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore.
2 Q9H0H5 (/IMP) Q9H0H5 (/IMP)
Regulation of microtubule cytoskeleton organization GO:0070507
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
2 A1Z9I5 (/IMP) Q9N9Z9 (/IMP)
Regulation of stem cell differentiation GO:2000736
Any process that modulates the frequency, rate or extent of stem cell differentiation.
2 A1Z9I5 (/IMP) Q9N9Z9 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q9WVM1 (/ISO)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q9WVM1 (/ISS)
Actomyosin contractile ring assembly GO:0000915
The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
1 Q9WVM1 (/ISO)
Actomyosin contractile ring assembly GO:0000915
The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
1 Q9WVM1 (/ISS)
Cell fate determination GO:0001709
A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
1 A1Z9I5 (/IMP)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
1 P40809 (/IMP)
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
1 P40809 (/IDA)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P40809 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q9WVM1 (/ISS)
Neuroblast proliferation GO:0007405
The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
1 Q9WVM1 (/IEP)
Sulfate transport GO:0008272
The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9WVM1 (/ISO)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 A1Z9I5 (/IMP)
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
1 Q9WVM1 (/ISO)
Positive regulation of cytokinesis GO:0032467
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
1 Q9WVM1 (/ISS)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 A1Z9I5 (/IMP)
Regulation of embryonic development GO:0045995
Any process that modulates the frequency, rate or extent of embryonic development.
1 Q9WVM1 (/IMP)
Mitotic spindle midzone assembly GO:0051256
The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.
1 Q9WVM1 (/ISO)
Mitotic spindle midzone assembly GO:0051256
The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.
1 Q9WVM1 (/ISS)
Regulation of attachment of spindle microtubules to kinetochore GO:0051988
Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore.
1 Q9WVM1 (/ISO)
Regulation of attachment of spindle microtubules to kinetochore GO:0051988
Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore.
1 Q9WVM1 (/ISS)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 A1Z9I5 (/IGI)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 A1Z9I5 (/IMP)

There are 27 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 A0A024R136 (/IDA) A0A024R136 (/IDA) Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 A1Z9I5 (/IDA) Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9H0H5 (/TAS) Q9H0H5 (/TAS)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 A1Z9I5 (/IDA) Q9N9Z9 (/IDA)
Spindle midzone GO:0051233
The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q9H0H5 (/HDA) Q9H0H5 (/HDA)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
2 Q9H0H5 (/IMP) Q9H0H5 (/IMP)
Centralspindlin complex GO:0097149
A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).
2 Q9H0H5 (/IDA) Q9H0H5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9WVM1 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9WVM1 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9WVM1 (/ISO)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
1 Q9WVM1 (/ISO)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
1 Q9WVM1 (/ISS)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
1 Q9WVM1 (/ISO)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
1 Q9WVM1 (/ISS)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
1 Q9WVM1 (/ISO)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
1 Q9WVM1 (/ISS)
Spindle midzone GO:0051233
The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
1 Q9WVM1 (/ISO)
Spindle midzone GO:0051233
The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
1 Q9WVM1 (/ISS)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
1 Q9WVM1 (/ISO)
Mitotic spindle GO:0072686
A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
1 Q9WVM1 (/ISS)
Centralspindlin complex GO:0097149
A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).
1 Q9WVM1 (/ISO)
Centralspindlin complex GO:0097149
A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).
1 Q9WVM1 (/ISS)
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