The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Rho GTPase activation protein
".
FunFam 24: Rho GTPase-activating protein 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
6 | P85298 (/IDA) Q07960 (/IDA) Q5FWK3 (/IDA) Q8IZM6 (/IDA) Q9VTU3 (/IDA) Q9VTU3 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P85298 (/IPI) Q07960 (/IPI) Q5FWK3 (/IPI) |
|
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
3 | Q07960 (/IPI) Q9VTU3 (/IPI) Q9VTU3 (/IPI) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
2 | Q5FWK3 (/ISO) Q9CXP4 (/ISO) |
|
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
1 | Q07960 (/TAS) |
|
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
1 | Q07960 (/TAS) |
|
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
1 | Q5FWK3 (/ISO) |
|
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
1 | Q07960 (/HDA) |
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
|
3 | P85298 (/TAS) Q07960 (/TAS) Q8IZM6 (/TAS) |
|
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
|
2 | Q9VTU3 (/IDA) Q9VTU3 (/IDA) |
|
Ventral furrow formation GO:0007370
Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation.
|
2 | Q9VTU3 (/IMP) Q9VTU3 (/IMP) |
|
Imaginal disc-derived leg morphogenesis GO:0007480
The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster.
|
2 | Q9VTU3 (/IMP) Q9VTU3 (/IMP) |
|
Positive regulation of synaptic growth at neuromuscular junction GO:0045887
Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction.
|
2 | Q9VTU3 (/IDA) Q9VTU3 (/IDA) |
|
Negative regulation of stress fiber assembly GO:0051497
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
2 | Q9VTU3 (/IDA) Q9VTU3 (/IDA) |
|
Negative regulation of endocytic recycling GO:2001136
Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling.
|
2 | Q9VTU3 (/IDA) Q9VTU3 (/IDA) |
|
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
|
1 | Q07960 (/IDA) |
|
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
|
1 | Q5FWK3 (/ISO) |
|
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
|
1 | Q07960 (/TAS) |
|
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
|
1 | Q07960 (/IMP) |
|
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
|
1 | Q5FWK3 (/ISO) |
|
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q8IZM6 (/IDA) |
|
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | Q8IZM6 (/IDA) |
|
Transferrin transport GO:0033572
The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q07960 (/IMP) |
|
Transferrin transport GO:0033572
The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q5FWK3 (/ISO) |
|
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
1 | Q5FWK3 (/IDA) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | P85298 (/IDA) |
|
Negative regulation of endocytic recycling GO:2001136
Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling.
|
1 | Q07960 (/IMP) |
|
Negative regulation of endocytic recycling GO:2001136
Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling.
|
1 | Q5FWK3 (/ISO) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P85298 (/TAS) Q07960 (/TAS) Q8IZM6 (/TAS) |
|
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
|
2 | Q9VTU3 (/IDA) Q9VTU3 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
2 | D4A6C5 (/IDA) Q07960 (/IDA) |
|
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
|
2 | Q9VTU3 (/IDA) Q9VTU3 (/IDA) |
|
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
1 | Q5FWK3 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q07960 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q5FWK3 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q5FWK3 (/IDA) |
|
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
|
1 | Q07960 (/IDA) |
|
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
|
1 | Q5FWK3 (/ISO) |
|
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
|
1 | Q5FWK3 (/IDA) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q5FWK3 (/ISO) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q07960 (/HDA) |
