The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Interleukin 1 receptor-associated kinase 4Interleukin-1 receptor-associated kinase-like 2Protein TubeSC:2Tumor necrosis factor receptor superfamily member 21Apoptosis-associated speck-like protein containing a CARDApoptotic protease-activating factor 1Caspase recruitment domain-containing protein 19Caspase 1, isoform CRA_bReceptor-interacting serine/threonine-protein kinase 2Death domain-containing membrane protein NRADDSC:3Ankyrin-3 isoform 2NACHT, LRR and PYD domains-containing protein 3Tumor necrosis factor receptor superfamily member 1Anuclear factor NF-kappa-B p100 subunit isoform X1Ankyrin-2SC:4Unc-5 netrin receptor BAnkyrin 1Nuclear factor NF-kappa-B p105 subunit isoform 1caspase-8 isoform X1THO complex subunit 1astrocytic phosphoprotein PEA-15 isoform X1Myeloid differentiation primary response protein MyD88p53-induced death domain-containing protein 1 isoform X1death domain-containing protein CRADD isoform X1Fas-associated via death domainViral CASP8 and FADD-like apoptosis regulatorSC:5Myeloid cell nuclear differentiation antigenMEFV, pyrin innate immunity regulatorNLR family pyrin domain containing 1NLR family pyrin domain containing 12NACHT, LRR and PYD domains-containing protein 6NLR family pyrin domain containing 7Interferon-inducible protein AIM2SC:6caspase-8 isoform X1NLR family pyrin domain containing 10Viral CASP8 and FADD-like apoptosis regulatorSC:7nucleolar protein 3 isoform X5Mucosa-associated lymphoid tissue lymphoma translocation protein 1Nucleotide-binding oligomerization domain-containing protein 1Tumor necrosis factor receptor superfamily member 6SC:8death domain-containing protein CRADD isoform X1B-cell lymphoma/leukemia 10Caspase 9Cell death protein 4SC:9baculoviral IAP repeat-containing protein 2Caspase recruitment domain family, member 11Death effector domain-containing protein-likeTumor necrosis factor receptor superfamily member EDARDeath associated protein kinase 1tumor necrosis factor receptor superfamily member 21CASP8 and FADD-like apoptosis regulatorCASP8 and FADD like apoptosis regulatorDNA-binding death effector domain-containing protein 2caspase-2 isoform X1Interleukin-1 receptor-associated kinase 1 (Predicted)Nucleotide-binding oligomerization domain-containing protein 2tumor necrosis factor receptor superfamily member 16Ankyrin 2, isoform MCaspase 10tumor necrosis factor receptor superfamily member 25Tumor necrosis factor receptor type 1-associated DEATH domain proteinTumor necrosis factor receptor superfamily member 10ANucleotide-binding oligomerization domain-containing protein 2Si:ch211-196f19.1E3 ubiquitin-protein ligase XIAPBaculoviral IAP repeat containing 2Putative receptor-interacting serine/threonine-protein kinase 1Apoptosis-associated speck-like protein containing a CARDUnc-5 family C-terminal likeInterleukin-1 receptor-associated kinase 3NACHT, LRR and PYD domains-containing protein 14Fas-associated via death domaindisks large homolog 5 isoform X2Mitochondrial antiviral-signaling proteinEctodysplasin-A receptor-associated adapter proteinTumor necrosis factor receptor superfamily member 11BNLR family pyrin domain containing 2NLR family CARD domain containing 4Caspase 10NACHT, LRR and PYD domains-containing protein 5Probable ATP-dependent RNA helicase DDX58Inactive caspase-12Baculoviral IAP repeat containing 7Interferon-induced helicase C domain-containing protein 1Probable ATP-dependent RNA helicase DDX58IGF like family receptor 1Uncharacterized proteinApoptotic protease-activating factor 1Uncharacterized proteinLeucine rich repeats and death domain containing 1Interferon-induced with helicase C domain 1Baculoviral IAP repeat containing 7AO66 ankyrinUncharacterized proteinP53-induced death domain protein 1E3 ubiquitin-protein ligase TTC3Caspase recruitment domain family member 8Netrin receptor unc-5Death-associated protein kinase dapk-1Interleukin-1 receptor-associated kinasePredicted proteinNeurotrophin receptor associated death domainDeath effector domain-containing 1Hematopoietic death receptorUncharacterized proteinNLR family pyrin domain containing 11Receptor-interacting serine/threonine kinase 1ImdMALT1 paracaspaseSi:dkey-103e21.5Fas-associated death domain proteinUnc-5, isoform BNucleotide-binding oligomerization domain-containing protein 1THO complex 1GG10810astrocytic phosphoprotein PEA-15 isoform X2astrocytic phosphoprotein PEA-15 isoform X2Uncharacterized proteinBaculoviral IAP repeat-containing 3Caspase DroncUncharacterized proteinCaspase-15Uncharacterized proteinTUBEMucosa-associated lymphoid tissue lymphoma translocation protein 1B-cell lymphoma/leukemia 10-likeUncharacterized proteinCaspase 8aNerve growth factor receptor bUncharacterized proteinUncharacterized proteinTumor necrosis factor receptor superfamily, member 1aUncharacterized proteinUncharacterized proteinPredicted proteinFas-associated death domain proteinCell death protein 3Caspase bNetrin receptor unc-5SBP (S-ribonuclease binding protein) family proteinInterferon-induced with helicase C domain 1Uncharacterized proteinInterleukin-1 receptor-associated kinase 4Uncharacterized proteinUncharacterized proteinCaspase 8, apoptosis-related cysteine peptidase,-like 2Apoptosis-associated speck-like protein-containing a CARDUncharacterized proteinCaspase recruitment domain family, member 6Uncharacterized proteinCASP2 and RIPK1 domain containing adaptor with death domainCASP2 and RIPK1 domain containing adaptor with death domainCaspase-8Caspase-8Uncharacterized proteinZgc:194469NALP2Baculoviral IAP repeat-containing protein 7Predicted proteinUncharacterized proteinUncharacterized proteinMyeloid differentiation primary response protein MyD88Putative BOI-related E3 ubiquitin-protein ligase 3Cyclin T-dependent kinase CDK9, putativeAnkyrinMelanoma differentiation associated gene 5Nerve growth factor receptorNOD2b proteinGuanylate-binding protein 4Uncharacterized proteinUncharacterized proteinX-linked inhibitor of apoptosisPredicted proteinCaspase 9Apoptotic protease-activating factor, putativeBaculoviral IAP repeat-containing protein 7CARD domain-containing protein E10THO complex subunit 1 isoform X1Uncharacterized proteinSi:dkeyp-97b10.3Putative nuclear matrix proteinSi:dkeyp-97b10.3Predicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinPredicted proteinV-FLIPUncharacterized proteinPredicted proteinProtein MC160MC160Apoptosis-associated speck-like protein containing a CARDV-FLIPUncharacterized proteinUncharacterized proteinUncharacterized proteinCaspaseUncharacterized proteinCARD15Uncharacterized proteinUncharacterized proteinDeath-associated inhibitor of apoptosis 2Predicted proteinCARD- and ANK-containing Inflammasome Adaptor ProteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinTumor necrosis factor receptor superfamily, member 1aPredicted proteinUncharacterized proteinTumor necrosis factor receptor superfamily member 6Fas cell surface death receptorAnkyrin-3Predicted proteinPredicted proteinE3 ubiquitin-protein ligase HERC2NLR family, CARD domain-containing 3-like 1Uncharacterized proteinImportin subunit alpha-7Uncharacterized proteinUncharacterized proteinSi:dkey-61p9.9Predicted proteinUncharacterized proteinPutative BOI-related E3 ubiquitin-protein ligase 3Predicted proteininterleukin-1 receptor-associated kinase 4Ssl-1Uncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinSi:dkey-265e15.2Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinCaspase 10Uncharacterized proteinUncharacterized proteinCASP8 and FADD-like apoptosis regulator aUncharacterized proteinUncharacterized proteinUncharacterized proteinCaspase-8Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinBaculoviral IAP repeat containing 7Uncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinTumor necrosis factor receptor superfamily member 10bUncharacterized proteinUncharacterized proteinSi:ch211-112c15.8Uncharacterized proteinPredicted proteinSi:ch211-108d22.2Uncharacterized proteinPredicted proteinUncharacterized proteinPutative inhibitor of apoptosisUncharacterized proteinUncharacterized proteinNLR family, CARD domain-containing 3-likeUncharacterized proteinUncharacterized proteinUncharacterized proteinI Kappa B homologUncharacterized proteinPredicted proteinUncharacterized proteinPredicted proteinNLR family CARD domain containing 3Uncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinNACHT, LRR and PYD domains-containing protein 9BUncharacterized proteinUncharacterized proteinUncharacterized proteinApoptosis 2 inhibitor-like ProteinUncharacterized proteinRetinoic acid-inducible protein IaUncharacterized proteinInterleukin 1 receptor associated kinase 1Retinoic acid-inducible protein IaUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinBaculoviral IAP repeat containing 7Uncharacterized proteinUncharacterized proteinUncharacterized protein
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FunFam 37: Receptor-interacting serine/threonine-protein kina...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 O43353 (/TAS) O43353 (/TAS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 O43353 (/IPI) O43353 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 P58801 (/ISO) P58801 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O43353 (/IPI) O43353 (/IPI)
LIM domain binding GO:0030274
Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.
2 O43353 (/IPI) O43353 (/IPI)
LIM domain binding GO:0030274
Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.
2 P58801 (/ISO) P58801 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 O43353 (/IPI) O43353 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P58801 (/ISO) P58801 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 O43353 (/IDA) O43353 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P58801 (/ISO) P58801 (/ISO)
Showing 1 to 10 of 16 entries

There are 99 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
4 P58801 (/IMP) P58801 (/IMP) Q4V958 (/IMP) Q8JHU4 (/IMP)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
4 O43353 (/IMP) O43353 (/IMP) P58801 (/IMP) P58801 (/IMP)
Adaptive immune response GO:0002250
An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
3 O43353 (/ISS) O43353 (/ISS) Q3SZJ2 (/ISS)
I-kappaB kinase/NF-kappaB signaling GO:0007249
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
3 O43353 (/ISS) O43353 (/ISS) Q3SZJ2 (/ISS)
Positive regulation of peptidyl-threonine phosphorylation GO:0010800
Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
3 P58801 (/ISS) P58801 (/ISS) Q3SZJ2 (/ISS)
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
3 P58801 (/ISS) P58801 (/ISS) Q3SZJ2 (/ISS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
3 O43353 (/ISS) O43353 (/ISS) Q3SZJ2 (/ISS)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
3 P58801 (/ISS) P58801 (/ISS) Q3SZJ2 (/ISS)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
3 O43353 (/ISS) O43353 (/ISS) Q3SZJ2 (/ISS)
Cellular response to muramyl dipeptide GO:0071225
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
3 P58801 (/ISS) P58801 (/ISS) Q3SZJ2 (/ISS)
Showing 1 to 10 of 99 entries

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 A0A0S2Z4Z8 (/IDA) A0A0S2Z4Z8 (/IDA) O43353 (/IDA) O43353 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 O43353 (/TAS) O43353 (/TAS) P58801 (/TAS) P58801 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P58801 (/ISS) P58801 (/ISS) Q3SZJ2 (/ISS)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
3 P58801 (/ISS) P58801 (/ISS) Q3SZJ2 (/ISS)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
3 P58801 (/ISS) P58801 (/ISS) Q3SZJ2 (/ISS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 P58801 (/ISS) P58801 (/ISS) Q3SZJ2 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O43353 (/IDA) O43353 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P58801 (/ISO) P58801 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P58801 (/ISO) P58801 (/ISO)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2 O43353 (/IDA) O43353 (/IDA)
Showing 1 to 10 of 16 entries
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