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CATH Superfamily 1.10.533.10

Death Domain, Fas

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Death Domain, Fas
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Interleukin 1 receptor-associated kinase 4Interleukin-1 receptor-associated kinase-like 2Protein TubeSC:2Tumor necrosis factor receptor superfamily member 21Apoptosis-associated speck-like protein containing a CARDApoptotic protease-activating factor 1Caspase recruitment domain-containing protein 19Caspase 1, isoform CRA_bReceptor-interacting serine/threonine-protein kinase 2Death domain-containing membrane protein NRADDSC:3Ankyrin-3 isoform 2NACHT, LRR and PYD domains-containing protein 3Tumor necrosis factor receptor superfamily member 1Anuclear factor NF-kappa-B p100 subunit isoform X1Ankyrin-2SC:4Unc-5 netrin receptor BAnkyrin 1Nuclear factor NF-kappa-B p105 subunit isoform 1caspase-8 isoform X1THO complex subunit 1astrocytic phosphoprotein PEA-15 isoform X1Myeloid differentiation primary response protein MyD88p53-induced death domain-containing protein 1 isoform X1death domain-containing protein CRADD isoform X1Fas-associated via death domainViral CASP8 and FADD-like apoptosis regulatorSC:5Myeloid cell nuclear differentiation antigenMEFV, pyrin innate immunity regulatorNLR family pyrin domain containing 1NLR family pyrin domain containing 12NACHT, LRR and PYD domains-containing protein 6NLR family pyrin domain containing 7Interferon-inducible protein AIM2SC:6caspase-8 isoform X1NLR family pyrin domain containing 10Viral CASP8 and FADD-like apoptosis regulatorSC:7nucleolar protein 3 isoform X5Mucosa-associated lymphoid tissue lymphoma translocation protein 1Nucleotide-binding oligomerization domain-containing protein 1Tumor necrosis factor receptor superfamily member 6SC:8death domain-containing protein CRADD isoform X1B-cell lymphoma/leukemia 10Caspase 9Cell death protein 4SC:9baculoviral IAP repeat-containing protein 2Caspase recruitment domain family, member 11Death effector domain-containing protein-likeTumor necrosis factor receptor superfamily member EDARDeath associated protein kinase 1tumor necrosis factor receptor superfamily member 21CASP8 and FADD-like apoptosis regulatorCASP8 and FADD like apoptosis regulatorDNA-binding death effector domain-containing protein 2caspase-2 isoform X1Interleukin-1 receptor-associated kinase 1 (Predicted)Nucleotide-binding oligomerization domain-containing protein 2tumor necrosis factor receptor superfamily member 16Ankyrin 2, isoform MCaspase 10tumor necrosis factor receptor superfamily member 25Tumor necrosis factor receptor type 1-associated DEATH domain proteinTumor necrosis factor receptor superfamily member 10ANucleotide-binding oligomerization domain-containing protein 2Si:ch211-196f19.1E3 ubiquitin-protein ligase XIAPBaculoviral IAP repeat containing 2Putative receptor-interacting serine/threonine-protein kinase 1Apoptosis-associated speck-like protein containing a CARDUnc-5 family C-terminal likeInterleukin-1 receptor-associated kinase 3NACHT, LRR and PYD domains-containing protein 14Fas-associated via death domaindisks large homolog 5 isoform X2Mitochondrial antiviral-signaling proteinEctodysplasin-A receptor-associated adapter proteinTumor necrosis factor receptor superfamily member 11BNLR family pyrin domain containing 2NLR family CARD domain containing 4Caspase 10NACHT, LRR and PYD domains-containing protein 5Probable ATP-dependent RNA helicase DDX58Inactive caspase-12Baculoviral IAP repeat containing 7Interferon-induced helicase C domain-containing protein 1Probable ATP-dependent RNA helicase DDX58IGF like family receptor 1Uncharacterized proteinApoptotic protease-activating factor 1Uncharacterized proteinLeucine rich repeats and death domain containing 1Interferon-induced with helicase C domain 1Baculoviral IAP repeat containing 7AO66 ankyrinUncharacterized proteinP53-induced death domain protein 1E3 ubiquitin-protein ligase TTC3Caspase recruitment domain family member 8Netrin receptor unc-5Death-associated protein kinase dapk-1Interleukin-1 receptor-associated kinasePredicted proteinNeurotrophin receptor associated death domainDeath effector domain-containing 1Hematopoietic death receptorUncharacterized proteinNLR family pyrin domain containing 11Receptor-interacting serine/threonine kinase 1ImdMALT1 paracaspaseSi:dkey-103e21.5Fas-associated death domain proteinUnc-5, isoform BNucleotide-binding oligomerization domain-containing protein 1THO complex 1GG10810astrocytic phosphoprotein PEA-15 isoform X2astrocytic phosphoprotein PEA-15 isoform X2Uncharacterized proteinBaculoviral IAP repeat-containing 3Caspase DroncUncharacterized proteinCaspase-15Uncharacterized proteinTUBEMucosa-associated lymphoid tissue lymphoma translocation protein 1B-cell lymphoma/leukemia 10-likeUncharacterized proteinCaspase 8aNerve growth factor receptor bUncharacterized proteinUncharacterized proteinTumor necrosis factor receptor superfamily, member 1aUncharacterized proteinUncharacterized proteinPredicted proteinFas-associated death domain proteinCell death protein 3Caspase bNetrin receptor unc-5SBP (S-ribonuclease binding protein) family proteinInterferon-induced with helicase C domain 1Uncharacterized proteinInterleukin-1 receptor-associated kinase 4Uncharacterized proteinUncharacterized proteinCaspase 8, apoptosis-related cysteine peptidase,-like 2Apoptosis-associated speck-like protein-containing a CARDUncharacterized proteinCaspase recruitment domain family, member 6Uncharacterized proteinCASP2 and RIPK1 domain containing adaptor with death domainCASP2 and RIPK1 domain containing adaptor with death domainCaspase-8Caspase-8Uncharacterized proteinZgc:194469NALP2Baculoviral IAP repeat-containing protein 7Predicted proteinUncharacterized proteinUncharacterized proteinMyeloid differentiation primary response protein MyD88Putative BOI-related E3 ubiquitin-protein ligase 3Cyclin T-dependent kinase CDK9, putativeAnkyrinMelanoma differentiation associated gene 5Nerve growth factor receptorNOD2b proteinGuanylate-binding protein 4Uncharacterized proteinUncharacterized proteinX-linked inhibitor of apoptosisPredicted proteinCaspase 9Apoptotic protease-activating factor, putativeBaculoviral IAP repeat-containing protein 7CARD domain-containing protein E10THO complex subunit 1 isoform X1Uncharacterized proteinSi:dkeyp-97b10.3Putative nuclear matrix proteinSi:dkeyp-97b10.3Predicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinPredicted proteinV-FLIPUncharacterized proteinPredicted proteinProtein MC160MC160Apoptosis-associated speck-like protein containing a CARDV-FLIPUncharacterized proteinUncharacterized proteinUncharacterized proteinCaspaseUncharacterized proteinCARD15Uncharacterized proteinUncharacterized proteinDeath-associated inhibitor of apoptosis 2Predicted proteinCARD- and ANK-containing Inflammasome Adaptor ProteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinTumor necrosis factor receptor superfamily, member 1aPredicted proteinUncharacterized proteinTumor necrosis factor receptor superfamily member 6Fas cell surface death receptorAnkyrin-3Predicted proteinPredicted proteinE3 ubiquitin-protein ligase HERC2NLR family, CARD domain-containing 3-like 1Uncharacterized proteinImportin subunit alpha-7Uncharacterized proteinUncharacterized proteinSi:dkey-61p9.9Predicted proteinUncharacterized proteinPutative BOI-related E3 ubiquitin-protein ligase 3Predicted proteininterleukin-1 receptor-associated kinase 4Ssl-1Uncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinSi:dkey-265e15.2Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinCaspase 10Uncharacterized proteinUncharacterized proteinCASP8 and FADD-like apoptosis regulator aUncharacterized proteinUncharacterized proteinUncharacterized proteinCaspase-8Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinBaculoviral IAP repeat containing 7Uncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinTumor necrosis factor receptor superfamily member 10bUncharacterized proteinUncharacterized proteinSi:ch211-112c15.8Uncharacterized proteinPredicted proteinSi:ch211-108d22.2Uncharacterized proteinPredicted proteinUncharacterized proteinPutative inhibitor of apoptosisUncharacterized proteinUncharacterized proteinNLR family, CARD domain-containing 3-likeUncharacterized proteinUncharacterized proteinUncharacterized proteinI Kappa B homologUncharacterized proteinPredicted proteinUncharacterized proteinPredicted proteinNLR family CARD domain containing 3Uncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinNACHT, LRR and PYD domains-containing protein 9BUncharacterized proteinUncharacterized proteinUncharacterized proteinApoptosis 2 inhibitor-like ProteinUncharacterized proteinRetinoic acid-inducible protein IaUncharacterized proteinInterleukin 1 receptor associated kinase 1Retinoic acid-inducible protein IaUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinBaculoviral IAP repeat containing 7Uncharacterized proteinUncharacterized proteinUncharacterized protein
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FunFam 170: Uncharacterized protein

GO Diversity

Unique GO annotations
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0 Unique GO terms

EC Diversity

Unique EC annotations
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0 Unique EC terms

Species Diversity

Unique species annotations
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3 Unique species

Statistics

Members
CATH Domains: 0
Sequences: 3
Annotations
Unique GO:
Unique EC: 0
Unique Species: 3
Representative
Rep ID: A8B9E6/320-362
Inherited Annotations: 0
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