The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Blc2-like
".
FunFam 10: BH3-interacting domain death agonist
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | P55957 (/IPI) P55957 (/IPI) P70444 (/IPI) Q9JLT6 (/IPI) Q9JLT6 (/IPI) |
|
Death receptor binding GO:0005123
Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
|
2 | P55957 (/TAS) P55957 (/TAS) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | P70444 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | P70444 (/IPI) |
Showing 1 to 4 of 4 entries
There are 50 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Release of cytochrome c from mitochondria GO:0001836
The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
|
5 | P55957 (/IDA) P55957 (/IDA) P70444 (/IDA) Q9JLT6 (/IDA) Q9JLT6 (/IDA) |
|
Positive regulation of protein homooligomerization GO:0032464
Any process that activates or increases the frequency, rate or extent of protein homooligomerization.
|
3 | P55957 (/IDA) P55957 (/IDA) P70444 (/IDA) |
|
Signal transduction in response to DNA damage GO:0042770
A cascade of processes induced by the detection of DNA damage within a cell.
|
3 | P55957 (/TAS) P55957 (/TAS) P70444 (/TAS) |
|
Positive regulation of release of cytochrome c from mitochondria GO:0090200
Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
|
3 | P55957 (/IGI) P55957 (/IGI) P70444 (/IGI) |
|
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
|
2 | Q9JLT6 (/IEP) Q9JLT6 (/IEP) |
|
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
2 | Q9JLT6 (/IEP) Q9JLT6 (/IEP) |
|
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
|
2 | P55957 (/TAS) P55957 (/TAS) |
|
Apoptotic mitochondrial changes GO:0008637
The morphological and physiological alterations undergone by mitochondria during apoptosis.
|
2 | P55957 (/TAS) P55957 (/TAS) |
|
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
2 | Q9JLT6 (/IEP) Q9JLT6 (/IEP) |
|
Positive regulation of protein oligomerization GO:0032461
Any process that activates or increases the frequency, rate or extent of protein oligomerization.
|
2 | P55957 (/IDA) P55957 (/IDA) |
Showing 1 to 10 of 50 entries
There are 14 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | A8ASI8 (/IDA) A8ASI8 (/IDA) P55957 (/IDA) P55957 (/IDA) P70444 (/IDA) Q9JLT6 (/IDA) Q9JLT6 (/IDA) |
|
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
|
5 | P70444 (/ISS) Q4JHS0 (/ISS) Q8JGM8 (/ISS) Q9JLT6 (/ISS) Q9JLT6 (/ISS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | P70444 (/IDA) Q9JLT6 (/IDA) Q9JLT6 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P55957 (/TAS) P55957 (/TAS) |
|
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
|
2 | P55957 (/IDA) P55957 (/IDA) |
|
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
|
2 | P55957 (/TAS) P55957 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P55957 (/TAS) P55957 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | P55957 (/TAS) P55957 (/TAS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P70444 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P70444 (/ISO) |
Showing 1 to 10 of 14 entries
