The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Ammonium transporter AmtB like domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: urea transporter 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Urea transmembrane transporter activity GO:0015204
Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.
5 P97689 (/IDA) Q62668 (/IDA) Q62668 (/IDA) Q8R4T9 (/IDA) Q8R4T9 (/IDA)
Urea channel activity GO:0015265
Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
4 C5MK33 (/ISS) D3INW7 (/ISS) P97689 (/ISS) Q8VHL0 (/ISS)
Urea transmembrane transporter activity GO:0015204
Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.
3 Q8R4T9 (/ISO) Q8R4T9 (/ISO) Q8VHL0 (/ISO)
Urea channel activity GO:0015265
Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
3 Q13336 (/IDA) Q13336 (/IDA) Q5QF96 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q62668 (/IPI) Q62668 (/IPI)
Urea transmembrane transporter activity GO:0015204
Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.
2 Q62668 (/NAS) Q62668 (/NAS)
Urea transmembrane transporter activity GO:0015204
Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.
2 Q15849 (/TAS) Q15849 (/TAS)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
2 Q15849 (/IDA) Q15849 (/IDA)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
2 Q8R4T9 (/ISO) Q8R4T9 (/ISO)
Water transmembrane transporter activity GO:0005372
Enables the transfer of water (H2O) from one side of a membrane to the other.
1 Q8VHL0 (/IDA)
Urea transmembrane transporter activity GO:0015204
Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2.
1 Q8VHL0 (/IMP)
Urea channel activity GO:0015265
Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 Q8VHL0 (/ISO)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Urea transport GO:0015840
The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.
4 Q13336 (/TAS) Q13336 (/TAS) Q15849 (/TAS) Q15849 (/TAS)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
4 Q13336 (/TAS) Q13336 (/TAS) Q15849 (/TAS) Q15849 (/TAS)
Urea transmembrane transport GO:0071918
The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
4 C5MK33 (/ISS) D3INW7 (/ISS) P97689 (/ISS) Q8VHL0 (/ISS)
Urea transport GO:0015840
The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.
3 P97689 (/IDA) Q62668 (/IDA) Q62668 (/IDA)
Urea transport GO:0015840
The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.
3 Q8R4T9 (/ISO) Q8R4T9 (/ISO) Q8VHL0 (/ISO)
Urea transmembrane transport GO:0071918
The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
3 Q13336 (/IDA) Q13336 (/IDA) Q5QF96 (/IDA)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
2 Q62668 (/IEP) Q62668 (/IEP)
Urea transport GO:0015840
The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.
2 Q533H0 (/IMP) Q8VHL0 (/IMP)
Urea transport GO:0015840
The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2.
2 Q62668 (/NAS) Q62668 (/NAS)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q8VHL0 (/IDA)
Water transport GO:0006833
The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q8VHL0 (/IGI)
Urea transmembrane transport GO:0071918
The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 Q8VHL0 (/ISO)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q13336 (/TAS) Q13336 (/TAS) Q15849 (/TAS) Q15849 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 C5MK33 (/ISS) D3INW7 (/ISS) P97689 (/ISS) Q8VHL0 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q15849 (/TAS) Q15849 (/TAS) Q8VHL0 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q13336 (/IDA) Q13336 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q13336 (/IDA) Q13336 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q13336 (/TAS) Q13336 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q15849 (/TAS) Q15849 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q8R4T9 (/ISS) Q8R4T9 (/ISS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 Q13336 (/IDA) Q13336 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q8VHL0 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8VHL0 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q5QF96 (/IMP)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q8VHL0 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q8VHL0 (/ISO)
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