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Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
2092 - - 84.7
2
1878
3D
4jtdH03 - 96.2
3
1821 - - 92.6
4
1678 - - 76.3
5
1667 - - 99.8
6
1597 - - 75.3
7
1548 - - 97.1
8
1491 - - 81.8
9
1447 - - 84.7
10
1385 - - 91.0
11
1280 - - 75.6
12
1256 - - 88.2
13
1234 - - 53.6
14
1101 - - 83.9
15
1067 - - 80.2
16
999 - - 81.9
17
996 - - 85.3
18
988 - - 82.2
19
919
3D
4kfmA02 - 95.4
20
886 - - 83.6
21
856 - - 87.8
22
795
3D
5wc5B00 - 81.3
23
781 - - 76.1
24
778 - - 72.8
25
721 - - 71.9
26
710 - - 57.1
27
678 - - 82.6
28
671 - - 91.8
29
559 - - 43.9
30
546 - - 89.0
31
544 - - 73.5
32
539 - - 76.9
33
521 - - 90.3
34
487 - - 66.3
35
Eag-related
460 - - 78.8
48
454
3D
6nmpP01 - 91.3
36
451 - - 92.3
37
442 - - 97.0
39
436
3D
5kumA02 - 77.9
43
436
3D
6cq9B00 - 75.3
38
434 - - 71.3
40
421 - - 70.2
41
418 - - 71.3
42
417 - - 75.0
44
395 - - 74.9
45
378 - - 77.3
46
375 - - 79.8
47
365 - - 80.0
49
355 - - 86.3
50
326
3D
6jb1G02 - 72.8
51
314 - - 82.3
52
306 - - 63.9
53
300 - - 51.1
54
283 - - 73.7
55
273 - - 94.1
56
266 - - 64.8
57
260 - - 80.1
58
258 - - 88.2
59
255 - - 72.0
60
232 - - 89.5
61
221 - - 95.0
62
207 - - 87.2
63
202 - - 81.7
64
198 - - 86.6
66
196 - - 60.0
65
196 - - 88.4
67
190 - - 71.9
68
184 - - 75.4
69
182 - - 58.1
70
176 - - 82.7
71
170 - - 58.6
72
161 - - 84.4
73
154 - - 92.0
74
139 - - 80.6
76
133
3D
3ukmD01 - 72.7
75
132 - - 74.8
77
124 - - 77.4
78
124 - - 87.9
79
108 - - 57.8
82
106
3D
6hu9o01 - 98.5
80
104 - - 67.4
81
103 - - 55.7
83
101 - - 27.3
84
100 - - 66.9
85
94 - - 46.4
86
89 - - 97.8
92
89
3D
3vouA00 - 27.1
87
88 - - 28.2
88
87 - - 91.2
89
84 - - 97.9
90
82 - - 77.2
91
81 - - 77.6
93
76 - - 94.0
94
75 - - 91.2
106
74
3D
4wfhB00 - 72.2
96
73 - - 59.2
95
73 - - 55.3
97
73 - - 96.5
98
71 - - 73.4
99
71 - - 40.8
100
67 - - 88.5
102
65 - - 75.4
101
65 - - 0.0
103
65 - - 59.3
104
63 - - 56.3
105
61 - - 95.8
107
59 - - 82.3
108
58 - - 77.9
109
57 - - 5.0
110
56 - - 89.0
112
55 - - 80.7
111
55 - - 44.3
113
54 - - 51.0
114
53 - - 75.4
115
53 - - 87.8
116
51 - - 57.0
118
50 - - 94.5
117
50 - - 99.5
121
49 - - 58.8
119
49 - - 77.2
122
49 - - 87.8
123
49 - - 95.9
120
49 - - 67.0
124
48 - - 76.4
125
48 - - 75.8
126
46 - - 17.8
128
45 - - 82.8
127
45 - - 81.0
276
44
3D
5iwoD00 - 74.4
129
43 - - 88.5
130
42 - - 81.3
131
41 - - 2.6
132
40 - - 88.6
134
40 - - 92.4
133
Potassium K ChaNNel, calcium activated
40 - - 22.3
135
39 - - 24.6
136
38 - - 63.4
137
38 - - 49.8
138
37 - - 73.9
139
36 - - 79.8
140
36 - - 80.9
144
35 - - 83.9
141
35 - - 71.1
142
35 - - 80.4
145
35 - - 61.7
143
35 - - 93.6
146
34 - - 16.5
148
33 - - 36.3
149
33 - - 74.8
150
33 - - 43.6
147
33 - - 21.2
151
32 - - 92.3
152
32 - - 12.2
153
31 - - 77.6
154
30 - - 68.2
155
29 - - 92.6
156
29 - - 86.0
157
28 - - 86.7
181
28
3D
3behD02 - 52.3
158
28 - - 23.6
160
27 - - 37.6
162
27 - - 98.8
161
27 - - 32.0
159
eag-related
27 - - 12.5
165
26 - - 67.7
163
26 - - 71.5
167
26 - - 76.1
166
26 - - 95.7
164
26 - - 70.6
169
24 - - 80.5
170
24 - - 86.9
168
24 - - 50.9
171
23 - - 46.7
172
23 - - 93.6
174
Potassium K ChaNNel, calcium activated
22 - - 72.4
173
22 - - 58.1
175
22 - - 59.7
178
21 - - 45.0
176
21 - - 58.6
179
21 - - 63.0
177
21 - - 39.0
183
Potassium K ChaNNel, calcium activated
20 - - 81.3
180
20 - - 89.0
185
20 - - 75.1
184
20 - - 36.7
182
20 - - 78.3
187
19 - - 73.4
186
19 - - 29.0
190
18 - - 78.7
498
18
3D
2x6bA01 - 8.2
191
18 - - 68.1
188
18 - - 35.9
189
18 - - 38.4
193
17 - - 92.6
194
17 - - 72.6
192
17 - - 43.9
197
16 - - 35.8
195
16 - - 73.8
198
16 - - 83.9
196
16 - - 39.3
199
16 - - 64.8
201
15 - - 72.0
204
15 - - 16.4
206
15 - - 38.8
202
15 - - 33.6
207
15 - - 72.7
200
15 - - 70.7
203
15 - - 22.9
205
15 - - 11.4
214
14 - - 14.8
211
14 - - 92.7
208
14 - - 87.1
212
14 - - 6.7
209
14 - - 70.5
216
14 - - 99.4
215
14 - - 93.7
213
14 - - 10.5
210
14 - - 90.2
222
VIC
13 - - 46.2
218
13 - - 26.0
219
Potassium K ChaNNel, calcium activated
13 - - 28.2
221
13 - - 53.4
217
13 - - 91.4
220
13 - - 16.6
226
12 - - 72.9
229
12 - - 17.1
228
12 - - 22.0
224
12 - - 9.7
223
12 - - 51.4
225
12 - - 71.9
230
Potassium
12 - - 44.4
227
12 - - 37.9
234
11 - - 36.6
238
11 - - 24.9
242
11 - - 90.0
231
11 - - 7.7
239
11 - - 12.3
244
11 - - 92.5
236
11 - - 50.1
232
AMPA
11 - - 43.6
241
11 - - 58.5
240
11 - - 10.7
243
11 - - 89.3
237
VIC
11 - - 9.9
235
11 - - 83.9
233
11 - - 17.7
246
10 - - 11.6
249
10 - - 33.2
250
10 - - 35.1
248
10 - - 75.2
245
10 - - 76.9
251
10 - - 36.2
247
Potassium
10 - - 13.0
255
9 - - 56.8
253
9 - - 15.6
260
9 - - 2.4
257
9 - - 24.4
263
9 - - 63.0
265
9 - - 89.6
749
9
3D
1lnqH01 - 0.0
259
9 - - 6.9
264
9 - - 61.2
252
9 - - 93.9
256
9 - - 68.4
261
9 - - 2.0
258
9 - - 6.4
266
9 - - 91.0
262
9 - - 6.7
254
9 - - 34.5
279
8 - - 8.1
280
8 - - 77.1
272
8 - - 13.6
267
8 - - 16.1
278
8 - - 76.4
274
8 - - 78.7
271
8 - - 13.3
275
8 - - 80.6
273
8 - - 36.7
268
8 - - 42.9
270
8 - - 90.1
282
8 - - 93.7
281
8 - - 92.5
277
Potassium K ChaNNel, calcium activated
8 - - 12.6
269
8 - - 21.0
295
7 - - 73.3
285
7 - - 46.3
293
7 - - 8.3
290
7 - - 14.2
283
7 - - 82.1
287
7 - - 90.6
297
7 - - 96.4
299
7 - - 93.9
289
7 - - 24.6
286
7 - - 94.7
292
7 - - 66.4
296
7 - - 88.8
298
7 - - 82.0
294
7 - - 6.2
288
7 - - 21.0
291
7 - - 11.8
284
7 - - 44.7
316
6 - - 54.9
309
6 - - 75.6
312
6 - - 8.9
302
6 - - 81.4
319
6 - - 82.3
306
6 - - 5.9
556
6
3D
3kg2D05 - 42.0
301
6 - - 77.1
308
6 - - 16.6
304
6 - - 8.4
314
6 - - 81.0
318
6 - - 73.8
311
6 - - 91.8
310
6 - - 90.8
313
6 - - 17.5
305
6 - - 12.5
315
6 - - 12.0
303
6 - - 16.0
300
6 - - 85.9
307
6 - - 9.0
317
6 - - 72.3
321
5 - - 38.1
348
5 - - 22.3
344
Potassium K ChaNNel, calcium activated
5 - - 10.2
341
5 - - 39.8
324
AMPA
5 - - 7.7
332
5 - - 66.9
328
5 - - 0.0
336
5 - - 16.3
339
5 - - 8.0
349
5 - - 47.8
350
5 - - 85.4
329
5 - - 26.1
353
5 - - 74.4
338
5 - - 10.9
326
5 - - 8.7
322
5 - - 8.0
334
5 - - 75.2
331
5 - - 32.0
355
5 - - 57.3
342
5 - - 21.8
346
5 - - 9.2
333
5 - - 63.3
330
5 - - 70.2
327
VIC
5 - - 10.1
347
5 - - 18.3
351
5 - - 76.8
335
5 - - 4.6
354
5 - - 65.5
345
5 - - 10.2
352
5 - - 76.1
325
5 - - 17.6
343
5 - - 43.8
340
5 - - 70.3
320
5 - - 38.1
337
5 - - 14.9
323
BK
5 - - 7.1
365
4 - - 9.4
374
4 - - 12.1
363
4 - - 17.8
360
4 - - 87.7
357
4 - - 6.0
378
Potassium K ChaNNel, calcium activated
4 - - 10.5
387
4 - - 57.7
371
4 - - 9.7
390
4 - - 74.3
393
4 - - 76.8
376
4 - - 8.7
367
4 - - 41.9
372
4 - - 8.9
380
4 - - 8.0
383
4 - - 74.8
379
4 - - 10.2
385
4 - - 47.8
369
4 - - 35.2
381
4 - - 19.9
384
4 - - 62.1
388
4 - - 70.2
391
4 - - 63.3
362
4 - - 6.8
358
4 - - 80.3
377
4 - - 24.7
366
4 - - 47.4
386
4 - - 45.3
382
4 - - 24.2
368
4 - - 28.9
370
4 - - 64.8
356
4 - - 72.2
373
4 - - 15.2
364
4 - - 10.0
361
4 - - 5.1
392
4 - - 73.4
375
4 - - 11.9
359
4 - - 24.1
389
4 - - 1.7
423
3 - - 0.0
437
3 - - 33.1
420
3 - - 74.8
417
3 - - 33.8
440
3 - - 35.8
443
3 - - 33.4
425
3 - - 0.0
407
3 - - 54.7
397
3 - - 58.0
445
3 - - 24.7
400
3 - - 61.0
403
3 - - 28.5
415
3 - - 18.4
435
3 - - 0.0
447
3 - - 39.8
395
3 - - 2.4
405
3 - - 32.9
427
3 - - 7.5
430
3 - - 3.1
433
3 - - 11.3
413
3 - - 9.7
410
3 - - 81.2
431
3 - - 7.8
446
3 - - 44.6
411
3 - - 12.5
442
3 - - 35.4
418
Isl
3 - - 36.6
414
3 - - 11.0
434
3 - - 23.0
422
3 - - 0.0
426
3 - - 8.6
438
3 - - 31.7
429
3 - - 33.8
404
3 - - 20.1
394
3 - - 46.3
398
3 - - 66.3
408
3 - - 60.9
401
3 - - 10.1
439
3 - - 60.8
406
3 - - 34.7
419
3 - - 0.0
396
3 - - 34.2
402
3 - - 64.8
412
CAKC
3 - - 5.3
441
3 - - 42.7
399
3 - - 11.1
409
3 - - 47.0
416
3 - - 15.2
436
3 - - 30.5
428
3 - - 24.9
432
3 - - 0.0
424
3 - - 5.0
421
3 - - 0.0
444
3 - - 55.9
448
3 - - 70.7
537
2 - - 7.6
459
2 - - 7.3
520
2 - - 9.9
523
2 - - 10.3
559
2 - - 35.6
489
2 - - 7.7
517
2 - - 3.4
543
2 - - 0.0
499
2 - - 11.0
475
2 - - 40.3
540
2 - - 0.0
561
2 - - 39.7
461
2 - - 0.0
492
2 - - 8.9
525
2 - - 0.0
496
2 - - 0.0
507
2 - - 28.7
482
2 - - 4.1
486
2 - - 0.7
452
2 - - 0.0
464
2 - - 8.8
473
2 - - 38.2
470
2 - - 11.3
456
2 - - 10.1
564
2 - - 33.4
552
2 - - 0.0
468
2 - - 30.0
545
2 - - 0.0
503
2 - - 27.1
491
2 - - 8.1
488
2 - - 4.3
484
2 - - 2.9
500
2 - - 25.0
466
2 - - 17.2
562
2 - - 36.6
554
2 - - 26.9
477
2 - - 41.5
458
2 - - 33.3
566
2 - - 0.0
454
2 - - 0.0
462
2 - - 7.6
558
2 - - 34.8
451
2 - - 2.6
515
2 - - 0.9
551
2 - - 2.3
481
2 - - 9.1
494
2 - - 4.5
535
2 - - 0.0
547
2 - - 10.8
505
2 - - 29.9
533
2 - - 3.9
527
2 - - 32.0
530
2 - - 30.6
469
2 - - 29.4
510
2 - - 36.6
513
2 - - 37.5
531
2 - - 7.8
485
CAKC
2 - - 0.0
542
2 - - 10.1
555
2 - - 31.7
546
2 - - 0.0
455
2 - - 0.0
511
2 - - 40.0
514
2 - - 12.7
518
2 - - 0.0
526
2 - - 32.5
479
2 - - 38.3
538
2 - - 0.0
534
2 - - 23.5
522
2 - - 0.0
495
2 - - 1.6
567
2 - - 48.8
453
2 - - 6.8
472
2 - - 31.0
550
2 - - 42.0
553
2 - - 4.2
467
2 - - 19.4
529
2 - - 8.9
450
2 - - 0.0
476
2 - - 40.4
483
2 - - 4.0
508
2 - - 38.6
504
2 - - 26.9
480
2 - - 42.9
501
2 - - 12.9
493
2 - - 1.1
549
2 - - 0.0
490
2 - - 10.6
449
2 - - 0.0
497
Potassium
2 - - 2.7
471
2 - - 34.8
478
2 - - 41.0
457
2 - - 37.9
563
2 - - 36.4
460
2 - - 5.2
539
2 - - 10.0
463
2 - - 3.1
557
2 - - 28.9
474
2 - - 37.5
560
2 - - 32.7
502
2 - - 0.0
487
2 - - 0.7
506
2 - - 30.1
519
2 - - 4.7
541
2 - - 3.1
509
2 - - 39.6
516
2 - - 3.7
512
2 - - 42.6
532
2 - - 0.0
524
2 - - 0.0
536
2 - - 11.0
528
2 - - 10.0
521
2 - - 2.0
465
2 - - 41.9
548
2 - - 1.0
544
2 - - 8.9
565
2 - - 44.0
782
1 - - 0.0
651
1 - - 0.0
804
1 - - 0.0
707
1 - - 0.0
786
1 - - 0.0
615
1 - - 0.0
745
1 - - 0.0
773
1 - - 0.0
698
1 - - 0.0
635
1 - - 0.0
752
1 - - 0.0
764
1 - - 0.0
681
1 - - 0.0
768
1 - - 0.0
589
1 - - 0.0
770
1 - - 0.0
694
1 - - 0.0
756
1 - - 0.0
688
1 - - 0.0
575
1 - - 0.0
600
1 - - 0.0
691
1 - - 0.0
603
1 - - 0.0
684
1 - - 0.0
599
eag-related
1 - - 0.0
761
1 - - 0.0
658
1 - - 0.0
677
1 - - 0.0
666
1 - - 0.0
792
1 - - 0.0
725
1 - - 0.0
796
1 - - 0.0
654
1 - - 0.0
662
1 - - 0.0
801
1 - - 0.0
799
1 - - 0.0
740
1 - - 0.0
630
1 - - 0.0
627
1 - - 0.0
669
1 - - 0.0
743
1 - - 0.0
633
1 - - 0.0
775
1 - - 0.0
613
1 - - 0.0
596
1 - - 0.0
592
1 - - 0.0
610
1 - - 0.0
586
1 - - 0.0
759
1 - - 0.0
723
1 - - 0.0
720
1 - - 0.0
582
1 - - 0.0
647
1 - - 0.0
737
1 - - 0.0
605
1 - - 0.0
570
1 - - 0.0
717
1 - - 0.0
789
1 - - 0.0
568
1 - - 0.0
573
1 - - 0.0
699
1 - - 0.0
640
1 - - 0.0
730
1 - - 0.0
584
1 - - 0.0
727
1 - - 0.0
591
1 - - 0.0
769
1 - - 0.0
643
1 - - 0.0
733
1 - - 0.0
588
1 - - 0.0
675
1 - - 0.0
713
1 - - 0.0
577
1 - - 0.0
710
1 - - 0.0
659
KCNK5
1 - - 0.0
623
1 - - 0.0
620
1 - - 0.0
747
1 - - 0.0
637
1 - - 0.0
594
1 - - 0.0
705
1 - - 0.0
617
1 - - 0.0
689
1 - - 0.0
581
1 - - 0.0
598
1 - - 0.0
682
1 - - 0.0
751
1 - - 0.0
607
1 - - 0.0
686
1 - - 0.0
715
1 - - 0.0
645
1 - - 0.0
798
1 - - 0.0
673
1 - - 0.0
735
1 - - 0.0
652
1 - - 0.0
664
1 - - 0.0
781
1 - - 0.0
668
1 - - 0.0
670
1 - - 0.0
656
1 - - 0.0
794
1 - - 0.0
788
1 - - 0.0
700
1 - - 0.0
806
1 - - 0.0
569
1 - - 0.0
791
1 - - 0.0
784
1 - - 0.0
703
1 - - 0.0
802
1 - - 0.0
661
1 - - 0.0
758
1 - - 0.0
777
1 - - 0.0
766
1 - - 0.0
692
1 - - 0.0
625
1 - - 0.0
754
1 - - 0.0
696
1 - - 0.0
762
1 - - 0.0
660
1 - - 0.0
657
1 - - 0.0
793
1 - - 0.0
585
1 - - 0.0
678
1 - - 0.0
639
1 - - 0.0
674
1 - - 0.0
790
1 - - 0.0
663
1 - - 0.0
701
1 - - 0.0
619
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687
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606
1 - - 0.0
602
1 - - 0.0
772
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729
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753
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697
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750
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776
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767
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671
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595
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704
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783
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708
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780
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576
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718
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621
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714
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572
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665
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779
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644
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722
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580
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734
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795
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583
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738
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726
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612
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590
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593
1 - - 0.0
785
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616
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731
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641
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636
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624
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805
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744
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634
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626
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571
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587
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693
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649
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601
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800
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702
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629
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797
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650
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676
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667
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683
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604
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608
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680
1 - - 0.0
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