The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Helix hairpin bin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Tubulin alpha chain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
197 P04688 (/IPI) P04689 (/IPI) P05213 (/IPI) P05213 (/IPI) P05213 (/IPI) P05213 (/IPI) P05213 (/IPI) P05213 (/IPI) P05213 (/IPI) P05213 (/IPI)
(187 more)
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
76 P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS)
(66 more)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
48 P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA)
(38 more)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
42 P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA)
(32 more)
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
42 P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO)
(32 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
42 P68363 (/IPI) P68363 (/IPI) P68363 (/IPI) P68363 (/IPI) P68363 (/IPI) P68363 (/IPI) P68363 (/IPI) P68363 (/IPI) P68363 (/IPI) P68363 (/IPI)
(32 more)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
42 P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO)
(32 more)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
34 P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA)
(24 more)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
34 P68369 (/ISO) P68369 (/ISO) P68369 (/ISO) P68369 (/ISO) P68369 (/ISO) P68369 (/ISO) P68369 (/ISO) P68369 (/ISO) P68369 (/ISO) P68369 (/ISO)
(24 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
34 P68370 (/TAS) P68370 (/TAS) P68370 (/TAS) P68370 (/TAS) P68370 (/TAS) P68370 (/TAS) P68370 (/TAS) P68370 (/TAS) P68370 (/TAS) P68370 (/TAS)
(24 more)
Showing 1 to 10 of 18 entries

There are 60 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
110 P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS)
(100 more)
Cytoskeleton-dependent intracellular transport GO:0030705
The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
76 P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS)
(66 more)
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
76 P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS)
(66 more)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
42 P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA)
(32 more)
Cellular response to interleukin-4 GO:0071353
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.
42 P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA)
(32 more)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
34 Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS)
(24 more)
Regulation of G2/M transition of mitotic cell cycle GO:0010389
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
34 Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS)
(24 more)
Regulation of synapse organization GO:0050807
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
34 P68369 (/IDA) P68369 (/IDA) P68369 (/IDA) P68369 (/IDA) P68369 (/IDA) P68369 (/IDA) P68369 (/IDA) P68369 (/IDA) P68369 (/IDA) P68369 (/IDA)
(24 more)
Regulation of synapse organization GO:0050807
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
34 P68369 (/IMP) P68369 (/IMP) P68369 (/IMP) P68369 (/IMP) P68369 (/IMP) P68369 (/IMP) P68369 (/IMP) P68369 (/IMP) P68369 (/IMP) P68369 (/IMP)
(24 more)
Ciliary basal body-plasma membrane docking GO:0097711
The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.
34 Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS) Q71U36 (/TAS)
(24 more)
Showing 1 to 10 of 60 entries

There are 59 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
203 P04689 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA)
(193 more)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
129 C9J2C0 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA) P68363 (/IDA)
(119 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
118 P05213 (/TAS) P05213 (/TAS) P05213 (/TAS) P05213 (/TAS) P05213 (/TAS) P05213 (/TAS) P05213 (/TAS) P05213 (/TAS) P05213 (/TAS) P05213 (/TAS)
(108 more)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
115 P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS) P68363 (/TAS)
(105 more)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
114 P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO)
(104 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
109 P04689 (/HDA) P06603 (/HDA) P06603 (/HDA) P06603 (/HDA) P06603 (/HDA) P06603 (/HDA) P06603 (/HDA) P06603 (/HDA) P06603 (/HDA) P06603 (/HDA)
(99 more)
Cytoplasmic microtubule GO:0005881
Any microtubule in the cytoplasm of a cell.
77 P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA) P05213 (/IDA)
(67 more)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
76 P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO) P05213 (/ISO)
(66 more)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
76 P05213 (/HDA) P05213 (/HDA) P05213 (/HDA) P05213 (/HDA) P05213 (/HDA) P05213 (/HDA) P05213 (/HDA) P05213 (/HDA) P05213 (/HDA) P05213 (/HDA)
(66 more)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
76 P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA) P68370 (/IDA)
(66 more)
Showing 1 to 10 of 59 entries
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