The mortality family of transcription factors (MORF) comprises three proteins, two of which (MRG15 and MRGX) promote cell proliferation while the third, MORF4, is involved in replicative senescence PMID:22244764. These are localized to the nucleus and have predicted motifs that indicate they function as chromatin remodelling complex components. Even though MORF4, MRG15 and MRGX have a different N-terminal part, they share a common C-terminal part, the MRG domain whose structure is shared by members of this superfamily. This domain is involved in the binding of a plethora of transcriptional regulators and chromatin-remodeling factors, such as the histone deacetylase transcriptional co-repressor mSin3A and the nuclear protein PAM14 (protein-associated MRG, 14kDa) PMID:9891081,PMID:11290425,PMID:22244764.