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CATH Superfamily 1.10.220.150

Arf GTPase activating protein

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Arf GTPase activating protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2ADP-ribosylation factor GTPase activating protein 1SC:2Arf-GAP with dual PH domain-containing protein 1Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1ARF GTPase-activating protein GIT2 isoform 1Putative ADP-ribosylation factor GTPase-activating protein 2Arf-GAP domain and FG repeat-containing protein 1arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3stromal membrane-associated protein 1 isoform X1Stromal membrane-associated proteinADP-ribosylation factor GTPase-activating protein AGD10Putative Arf GTPase-activating proteinADP-ribosylation factor GTPase-activating proteinarf-GAP with dual PH domain-containing protein 2 isoform X1Uncharacterized protein, isoform BARF GTPase activator (Csx2), putativeArf-GAP domain and FG repeat-containing protein 1ADP-ribosylation factor GTPase-activating protein AGD1ADP ribosylation factor GTPase activating protein 1Uncharacterized protein, isoform BADP-ribosylation factor GTPase-activating protein, putativeArf-GAP with ANK repeat and PH domain-containing protein cnt-2Uncharacterized proteinGTPase-activating protein, putativeGTPase activating protein for Arf, putativeGts1pADP-ribosylation factor GTPase activating protein 1, putativeCentaurin, alpha 1, isoform CRA_bGTPase activating protein for Arf, putativeARF GTPase activating protein, putativeARF GAPstromal membrane-associated protein 1 isoform X2Sporulation protein SPS18Arf GTPase activating proteinCRE-GIT-1 proteinUncharacterized proteinUncharacterized proteinADP-ribosylation factor GTPase activating protein, putativeUncharacterized proteinARF GAP-like zinc finger-containing proteinUncharacterized proteinARF GAPADP-ribosylation factor GTPase-activating protein 3 isoform X2Ultradian oscillation regulator, putativeADP ribosylation factor, putativearf-GAP domain and FG repeat-containing protein 1 isoform X6Uncharacterized proteinADP-ribosylation factor GTPase activating protein, putativeUncharacterized proteinADP-ribosylation factor GTPase activating protein, putativezinc finger protein Ci-ArfGAP-1 isoform X1Alpha-protein kinase 1Un-named sa1614uncharacterized protein LOC778851 isoform X2YALI0D07524pUncharacterized proteinUncharacterized proteinCentaurin gamma, putativeUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinArfGAPUncharacterized proteinArfGAP with SH3 domain, ankyrin repeat and PH domain 2aUncharacterized proteinADP-ribosylation factor GTPase-activating protein AGD10ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1Centaurin, alpha 1, isoform CRA_aUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinADP-ribosylation factor GTPase-activating protein AGD10Uncharacterized proteinUncharacterized proteinUncharacterized protein
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FunFam 16: Uncharacterized protein, isoform B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
 2 A0A0B4LEF8 (/ISM) A1Z7A6 (/ISM)
Phosphatidylinositol phosphate binding GO:1901981
Interacting selectively and non-covalently with phosphatidylinositol phosphate.
 2 A0A0B4LEF8 (/ISS) A1Z7A6 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 1 A1Z7A6 (/IPI)
Showing 1 to 3 of 3 entries

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
 2 A0A0B4LEF8 (/ISM) A1Z7A6 (/ISM)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
 1 A1Z7A6 (/IMP)
Regulation of Golgi organization GO:1903358
Any process that modulates the frequency, rate or extent of Golgi organization.
 1 A1Z7A6 (/IMP)
Positive regulation of cellular protein localization GO:1903829
Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
 1 A1Z7A6 (/IMP)
Mitotic cleavage furrow ingression GO:1990386
Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed.
 1 A1Z7A6 (/IMP)
Showing 1 to 5 of 5 entries

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 2 A0A0B4LEF8 (/IDA) A1Z7A6 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
 1 A1Z7A6 (/IDA)
Showing 1 to 2 of 2 entries
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