The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Frizzled cysteine-rich domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: Frizzled receptor 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 28 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
5 Q61088 (/IPI) Q61088 (/IPI) Q9NBW1 (/IPI) Q9NBW1 (/IPI) Q9QZH0 (/IPI)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q61088 (/IPI) Q61088 (/IPI) Q9ULV1 (/IPI)
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
3 Q61088 (/IPI) Q61088 (/IPI) Q9ULV1 (/IPI)
Showing 1 to 10 of 28 entries

There are 55 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Wnt signaling pathway, calcium modulating pathway GO:0007223
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Negative regulation of cell-substrate adhesion GO:0010812
Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Negative regulation of cell-substrate adhesion GO:0010812
Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
3 Q61088 (/IMP) Q61088 (/IMP) Q9ULV1 (/IMP)
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
3 Q61088 (/IGI) Q61088 (/IGI) Q9QZH0 (/IGI)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 Q61088 (/IDA) Q61088 (/IDA) Q9ULV1 (/IDA)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
3 Q61088 (/IDA) Q61088 (/IDA) Q9ULV1 (/IDA)
Showing 1 to 10 of 55 entries

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 Q61088 (/ISO) Q61088 (/ISO) Q9IA05 (/ISO) Q9PT62 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q61088 (/IDA) Q61088 (/IDA) Q9ULV1 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q61088 (/TAS) Q61088 (/TAS) Q9ULV1 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q61088 (/IMP) Q61088 (/IMP)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
2 Q61088 (/IDA) Q61088 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
2 Q9IA05 (/ISO) Q9PT62 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9NBW1 (/ISS) Q9NBW1 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 Q61088 (/IMP) Q61088 (/IMP)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
2 Q61088 (/IDA) Q61088 (/IDA)
Showing 1 to 10 of 17 entries
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