The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Frizzled cysteine-rich domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Frizzled class receptor 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 27 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 O75084 (/IPI) O75084 (/IPI) Q08463 (/IPI) Q08464 (/IPI) Q14332 (/IPI) Q14332 (/IPI) Q14332 (/IPI) Q14332 (/IPI) Q61090 (/IPI) Q8AVJ9 (/IPI)
(4 more)
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
9 O75084 (/IDA) O75084 (/IDA) Q08464 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q9JIP6 (/IDA) Q9UP38 (/IDA)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
7 O70421 (/IPI) O75084 (/IPI) O75084 (/IPI) Q61090 (/IPI) Q9PUK8 (/IPI) Q9PUK8 (/IPI) Q9UP38 (/IPI)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
7 O75084 (/NAS) O75084 (/NAS) Q14332 (/NAS) Q14332 (/NAS) Q14332 (/NAS) Q14332 (/NAS) Q9UP38 (/NAS)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
7 O75084 (/IPI) O75084 (/IPI) Q14332 (/IPI) Q14332 (/IPI) Q14332 (/IPI) Q14332 (/IPI) Q9UP38 (/IPI)
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
7 O75084 (/NAS) O75084 (/NAS) Q14332 (/NAS) Q14332 (/NAS) Q14332 (/NAS) Q14332 (/NAS) Q9UP38 (/NAS)
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
3 O75084 (/IPI) O75084 (/IPI) Q9UP38 (/IPI)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
3 O70421 (/ISO) Q61090 (/ISO) Q9JIP6 (/ISO)
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
3 O70421 (/ISO) Q61090 (/ISO) Q9JIP6 (/ISO)
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
2 O70421 (/ISO) Q61090 (/ISO)
Showing 1 to 10 of 27 entries

There are 120 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
9 O75084 (/IDA) O75084 (/IDA) Q08463 (/IDA) Q08464 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q9UP38 (/IDA)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
7 O75084 (/ISS) O75084 (/ISS) Q14332 (/ISS) Q14332 (/ISS) Q14332 (/ISS) Q14332 (/ISS) Q9UP38 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
7 O75084 (/IDA) O75084 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q9UP38 (/IDA)
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
7 A7YYJ5 (/IGI) Q6NV44 (/IGI) Q7SZR7 (/IGI) Q7ZU08 (/IGI) Q8QFM3 (/IGI) Q90ZT3 (/IGI) Q98SI2 (/IGI)
Wnt signaling pathway, planar cell polarity pathway GO:0060071
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
7 O75084 (/TAS) O75084 (/TAS) Q14332 (/TAS) Q14332 (/TAS) Q14332 (/TAS) Q14332 (/TAS) Q9UP38 (/TAS)
Epiboly GO:0090504
The expansion of one cell sheet over other cells or yolk.
7 A7YYJ5 (/IGI) Q6NV44 (/IGI) Q7SZR7 (/IGI) Q7ZU08 (/IGI) Q8QFM3 (/IGI) Q90ZT3 (/IGI) Q98SI2 (/IGI)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
6 Q08463 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q9UP38 (/IDA)
Wnt signaling pathway, planar cell polarity pathway GO:0060071
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
6 O75084 (/NAS) O75084 (/NAS) Q14332 (/NAS) Q14332 (/NAS) Q14332 (/NAS) Q14332 (/NAS)
Convergent extension involved in gastrulation GO:0060027
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
5 F1QBI2 (/IMP) Q8AVJ9 (/IMP) Q90YL7 (/IMP) Q9PUK8 (/IMP) Q9PUK8 (/IMP)
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
5 O70421 (/IGI) Q61090 (/IGI) Q9PUK8 (/IGI) Q9PUK8 (/IGI) Q9UP38 (/IGI)
Showing 1 to 10 of 120 entries

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
15 F1QBI2 (/IDA) O75084 (/IDA) O75084 (/IDA) Q08463 (/IDA) Q08464 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q61090 (/IDA)
(5 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
12 O75084 (/TAS) O75084 (/TAS) Q08463 (/TAS) Q08464 (/TAS) Q14332 (/TAS) Q14332 (/TAS) Q14332 (/TAS) Q14332 (/TAS) Q61090 (/TAS) Q9PUK8 (/TAS)
(2 more)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
5 Q14332 (/HDA) Q14332 (/HDA) Q14332 (/HDA) Q14332 (/HDA) Q9UP38 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA) Q14332 (/IDA)
Clathrin-coated endocytic vesicle membrane GO:0030669
The lipid bilayer surrounding a clathrin-coated endocytic vesicle.
4 Q14332 (/TAS) Q14332 (/TAS) Q14332 (/TAS) Q14332 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O70421 (/ISO) Q61090 (/ISO) Q9JIP6 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q8AVJ9 (/NAS) Q9PUK8 (/NAS) Q9PUK8 (/NAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 O75084 (/TAS) O75084 (/TAS) Q08464 (/TAS)
Recycling endosome membrane GO:0055038
The lipid bilayer surrounding a recycling endosome.
2 O75084 (/IDA) O75084 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9JIP6 (/ISO)
Showing 1 to 10 of 18 entries
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