The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
ARID DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Putative lysine-specific demethylase 5b

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 46 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 P29375 (/IPI) P41229 (/IPI) Q3UXZ9 (/IPI) Q80Y84 (/IPI) Q9BY66 (/IPI) Q9BY66 (/IPI) Q9UGL1 (/IPI) Q9VMJ7 (/IPI) Q9VMJ7 (/IPI)
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
6 A6N6J7 (/IDA) P41229 (/IDA) Q80Y84 (/IDA) Q9BY66 (/IDA) Q9BY66 (/IDA) Q9UGL1 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 P29375 (/ISA) P41229 (/ISA) Q9BY66 (/ISA) Q9BY66 (/ISA) Q9UGL1 (/ISA)
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
4 P41229 (/IMP) Q9UGL1 (/IMP) Q9VMJ7 (/IMP) Q9VMJ7 (/IMP)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P29375 (/IDA) P41229 (/IDA) Q9UGL1 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 P41230 (/ISO) Q3UXZ9 (/ISO) Q80Y84 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 Q3UXZ9 (/ISS) Q5F3R2 (/ISS) Q80Y84 (/ISS)
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
3 P41230 (/ISO) Q62240 (/ISO) Q80Y84 (/ISO)
Histone demethylase activity (H3-trimethyl-K4 specific) GO:0034647
Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein.
3 Q9UGL1 (/IMP) Q9VMJ7 (/IMP) Q9VMJ7 (/IMP)
Histone demethylase activity (H3-trimethyl-K4 specific) GO:0034647
Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein.
3 Q5F3R2 (/ISS) Q6IQX0 (/ISS) Q80Y84 (/ISS)
Showing 1 to 10 of 46 entries

There are 52 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
8 A6N6J7 (/IDA) P29375 (/IDA) P41229 (/IDA) P41230 (/IDA) Q80Y84 (/IDA) Q9BY66 (/IDA) Q9BY66 (/IDA) Q9UGL1 (/IDA)
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
5 P41229 (/IMP) Q3UXZ9 (/IMP) Q9UGL1 (/IMP) Q9VMJ7 (/IMP) Q9VMJ7 (/IMP)
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
4 P41230 (/ISO) Q3UXZ9 (/ISO) Q62240 (/ISO) Q80Y84 (/ISO)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
3 A0A096MJZ8 (/IEP) A0A0G2JTU9 (/IEP) E9PSW7 (/IEP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
3 A0A096MJZ8 (/IEP) A0A0G2JTU9 (/IEP) E9PSW7 (/IEP)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
3 Q3UXZ9 (/IMP) Q9VMJ7 (/IMP) Q9VMJ7 (/IMP)
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
3 A0A096MJZ8 (/IEP) A0A0G2JTU9 (/IEP) E9PSW7 (/IEP)
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
3 Q5F3R2 (/ISS) Q6IQX0 (/ISS) Q80Y84 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 P41230 (/IDA) Q80Y84 (/IDA) Q9UGL1 (/IDA)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
2 Q9VMJ7 (/IMP) Q9VMJ7 (/IMP)
Showing 1 to 10 of 52 entries

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 P29375 (/IDA) P41229 (/IDA) P41230 (/IDA) Q3UXZ9 (/IDA) Q9UGL1 (/IDA) Q9VMJ7 (/IDA) Q9VMJ7 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 P29375 (/TAS) P41229 (/TAS) Q9BY66 (/TAS) Q9BY66 (/TAS) Q9UGL1 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P41230 (/ISO) Q3UXZ9 (/ISO) Q80Y84 (/ISO)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
2 Q9BY66 (/IDA) Q9BY66 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P29375 (/TAS) Q9UGL1 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P41229 (/IDA) Q9UGL1 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P41230 (/ISO) Q80Y84 (/ISO)
Sin3-type complex GO:0070822
Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.
2 Q9VMJ7 (/IDA) Q9VMJ7 (/IDA)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
1 Q62240 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P41229 (/IDA)
Showing 1 to 10 of 14 entries
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