The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Tetraspanin
".
FunFam 16: Tetraspanin
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
7 | P30409 (/ISS) P30409 (/ISS) P30932 (/ISS) P40239 (/ISS) P40239 (/ISS) P40240 (/ISS) Q8WMQ3 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | P21926 (/IPI) P21926 (/IPI) P21926 (/IPI) P21926 (/IPI) P40240 (/IPI) P40241 (/IPI) P40241 (/IPI) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
4 | P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
3 | P40240 (/IPI) P40241 (/IPI) P40241 (/IPI) |
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
|
1 | P40240 (/ISO) |
There are 33 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Myoblast fusion involved in skeletal muscle regeneration GO:0014905
A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
12 |
P21926 (/ISS)
P21926 (/ISS)
P21926 (/ISS)
P21926 (/ISS)
P30409 (/ISS)
P30409 (/ISS)
P30932 (/ISS)
P40239 (/ISS)
P40239 (/ISS)
P40241 (/ISS)
(2 more) |
Paranodal junction assembly GO:0030913
Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier.
|
12 |
P21926 (/ISS)
P21926 (/ISS)
P21926 (/ISS)
P21926 (/ISS)
P30409 (/ISS)
P30409 (/ISS)
P30932 (/ISS)
P40239 (/ISS)
P40239 (/ISS)
P40241 (/ISS)
(2 more) |
Sperm-egg recognition GO:0035036
The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.
|
12 |
P21926 (/ISS)
P21926 (/ISS)
P21926 (/ISS)
P21926 (/ISS)
P30409 (/ISS)
P30409 (/ISS)
P30932 (/ISS)
P40239 (/ISS)
P40239 (/ISS)
P40241 (/ISS)
(2 more) |
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
|
10 | P21926 (/ISS) P21926 (/ISS) P21926 (/ISS) P21926 (/ISS) P30932 (/ISS) P40239 (/ISS) P40239 (/ISS) P40241 (/ISS) P40241 (/ISS) Q8WMQ3 (/ISS) |
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
|
10 | P21926 (/ISS) P21926 (/ISS) P21926 (/ISS) P21926 (/ISS) P30932 (/ISS) P40239 (/ISS) P40239 (/ISS) P40241 (/ISS) P40241 (/ISS) Q8WMQ3 (/ISS) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
9 | P30409 (/ISS) P30409 (/ISS) P30932 (/ISS) P40239 (/ISS) P40239 (/ISS) P40240 (/ISS) P40241 (/ISS) P40241 (/ISS) Q8WMQ3 (/ISS) |
Negative regulation of platelet aggregation GO:0090331
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
|
9 | P30409 (/ISS) P30409 (/ISS) P30932 (/ISS) P40239 (/ISS) P40239 (/ISS) P40240 (/ISS) P40241 (/ISS) P40241 (/ISS) Q8WMQ3 (/ISS) |
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
|
8 | P30409 (/ISS) P30409 (/ISS) P30932 (/ISS) P40239 (/ISS) P40239 (/ISS) P40241 (/ISS) P40241 (/ISS) Q8WMQ3 (/ISS) |
Fusion of sperm to egg plasma membrane involved in single fertilization GO:0007342
The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.
|
8 | P30409 (/ISS) P30409 (/ISS) P30932 (/ISS) P40239 (/ISS) P40239 (/ISS) P40241 (/ISS) P40241 (/ISS) Q8WMQ3 (/ISS) |
Negative regulation of cellular component movement GO:0051271
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component.
|
8 | P30409 (/ISS) P30409 (/ISS) P40239 (/ISS) P40239 (/ISS) P40240 (/ISS) P40241 (/ISS) P40241 (/ISS) Q8WMQ3 (/ISS) |
Fusion of sperm to egg plasma membrane involved in single fertilization GO:0007342
The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.
|
5 | P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) P40240 (/IDA) |
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
|
4 | P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
4 | P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) |
Fusion of sperm to egg plasma membrane involved in single fertilization GO:0007342
The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.
|
4 | P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) |
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
|
4 | P21926 (/NAS) P21926 (/NAS) P21926 (/NAS) P21926 (/NAS) |
Negative regulation of cellular component movement GO:0051271
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component.
|
4 | P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) |
Negative regulation of platelet aggregation GO:0090331
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
|
4 | P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) |
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
2 | P40241 (/IEP) P40241 (/IEP) |
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
|
2 | P40241 (/IEP) P40241 (/IEP) |
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
|
2 | P40241 (/IEP) P40241 (/IEP) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | P40240 (/ISO) |
Single fertilization GO:0007338
The union of male and female gametes to form a zygote.
|
1 | P40240 (/IDA) |
Fusion of sperm to egg plasma membrane involved in single fertilization GO:0007342
The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head.
|
1 | P40240 (/ISO) |
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | P40240 (/IDA) |
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
1 | P30932 (/ISS) |
Myoblast fusion involved in skeletal muscle regeneration GO:0014905
A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
1 | P40240 (/IMP) |
Paranodal junction assembly GO:0030913
Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier.
|
1 | P40240 (/IDA) |
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
|
1 | P40240 (/IDA) |
Sperm-egg recognition GO:0035036
The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.
|
1 | P40240 (/IDA) |
Negative regulation of cellular component movement GO:0051271
Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component.
|
1 | P40240 (/ISO) |
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
|
1 | P40240 (/IDA) |
Negative regulation of platelet aggregation GO:0090331
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
|
1 | P40240 (/ISO) |
Regulation of macrophage migration GO:1905521
Any process that modulates the frequency, rate or extent of macrophage migration.
|
1 | P40240 (/IDA) |
There are 22 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
10 | P21926 (/ISS) P21926 (/ISS) P21926 (/ISS) P21926 (/ISS) P30409 (/ISS) P30409 (/ISS) P30932 (/ISS) P40239 (/ISS) P40239 (/ISS) Q8WMQ3 (/ISS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
8 | P21926 (/ISS) P21926 (/ISS) P21926 (/ISS) P21926 (/ISS) P30932 (/ISS) P40239 (/ISS) P40239 (/ISS) Q8WMQ3 (/ISS) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
7 | P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) P21926 (/IDA) P40240 (/IDA) P40241 (/IDA) P40241 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) P40240 (/TAS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
4 | P21926 (/HDA) P21926 (/HDA) P21926 (/HDA) P21926 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P21926 (/NAS) P21926 (/NAS) P21926 (/NAS) P21926 (/NAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | P21926 (/NAS) P21926 (/NAS) P21926 (/NAS) P21926 (/NAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
4 | P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
4 | P21926 (/HDA) P21926 (/HDA) P21926 (/HDA) P21926 (/HDA) |
Endocytic vesicle membrane GO:0030666
The lipid bilayer surrounding an endocytic vesicle.
|
4 | P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) |
Clathrin-coated endocytic vesicle membrane GO:0030669
The lipid bilayer surrounding a clathrin-coated endocytic vesicle.
|
4 | P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) |
Platelet alpha granule membrane GO:0031092
The lipid bilayer surrounding the platelet alpha granule.
|
4 | P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) P21926 (/TAS) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
4 | P21926 (/HDA) P21926 (/HDA) P21926 (/HDA) P21926 (/HDA) |
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
|
4 | P21926 (/HDA) P21926 (/HDA) P21926 (/HDA) P21926 (/HDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | P40241 (/IDA) P40241 (/IDA) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
2 | P40241 (/IDA) P40241 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P40240 (/IDA) |
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | P40240 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | P40240 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P40240 (/IDA) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | P40240 (/ISO) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P40240 (/ISO) |