The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Neutral endopeptidase , domain2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Membrane metalloendopeptidase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 28 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
25 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(15 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Peptide binding GO:0042277
Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2 P08473 (/IDA) Q495T6 (/IDA)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2 Q61391 (/ISO) Q9JLI3 (/ISO)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 P08473 (/IDA) P0C1T0 (/IDA)
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2 Q61391 (/ISO) Q9JLI3 (/ISO)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 P08473 (/IDA) P0C1T0 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 Q61391 (/ISO) Q9JLI3 (/ISO)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
1 P08473 (/IDA)
Showing 1 to 10 of 28 entries

There are 49 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Peptide metabolic process GO:0006518
The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Sensory perception of pain GO:0019233
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Creatinine metabolic process GO:0046449
The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Amyloid-beta metabolic process GO:0050435
The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP).
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Cellular response to UV-A GO:0071492
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Cellular response to UV-B GO:0071493
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Replicative senescence GO:0090399
A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
23 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(13 more)
Showing 1 to 10 of 49 entries

There are 48 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Neuron projection terminus GO:0044306
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
24 E1BPL8 (/ISS) F1SJM4 (/ISS) F5C3N2 (/ISS) F5C3N2 (/ISS) F7B8E7 (/ISS) F7FEB8 (/ISS) F7H3Y6 (/ISS) F7H3Y6 (/ISS) G1PR64 (/ISS) G1QUC3 (/ISS)
(14 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 P07861 (/IDA) P0C1T0 (/IDA) Q495T6 (/IDA) Q61391 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P0C1T0 (/IDA) Q495T6 (/IDA)
Showing 1 to 10 of 48 entries
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