The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1DNA helicaseRecBCD enzyme subunit RecCDNA helicaseATP-dependent DNA helicaseDNA helicaseDNA helicaseATP-dependent DNA helicase Repp-loop containing nucleoside triphosphate hydrolase superfamily proteinDNA helicaseATP-dependent DNA helicase UvrDATP-dependent DNA helicase RepDNA helicaseDNA helicaseRecBCD enzyme subunit RecCUnplaced genomic scaffold supercont1.10, whole genome shotgun sequencePossible ATP-dependent DNA helicaseDNA helicaseDNA helicaseDNA helicaseDNA helicaseDNA helicasePROBABLE ATP-DEPENDENT DNA HELICASERecBCD enzyme subunit RecCATP-dependent DNA helicase RepExodeoxyribonuclease V, gamma subunitATP-dependent DNA helicaseDNA helicaseRecBCD enzyme subunit RecCDNA helicaseDNA helicaseDNA helicaseATP-dependent DNA helicaseATP-dependent DNA helicase, putativeDNA helicaseDNA helicaseDNA helicaseDNA helicaseDNA helicaseDNA helicaseDNA helicaseDNA helicaseP-loop containing nucleoside triphosphate hydrolase proteinDNA helicaseRecBCD enzyme subunit RecCAaceriAFR093WpDNA helicase IIPredicted proteinDNA helicaseUvrD/REP helicase family proteinDNA helicaseDNA helicasePredicted proteinUVRD/Rep like helicaseATP-dependent DNA helicase srs2DNA helicaseDNA helicaseDNA helicaseADR113WpDNA helicaseDNA helicaseUncharacterized proteinDNA helicaseProbable DNA helicase II homologUvrD/REP helicase family proteinDNA helicaseDNA helicaseATP-dependent DNA helicase
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FunFam 17: DNA helicase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC TermAnnotationsEvidence
DNA helicase. [EC: 3.6.4.12]
ATP + H(2)O = ADP + phosphate.
  • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
  • Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15).
  • Some helicases unwind DNA as well as RNA (4,9).
  • May be identical with EC 3.6.4.13 (RNA helicase).
64 A0A0H3ME77 A0A0H3ME77 A0A0H3ME77 A0A0H3ME77 A0A0H3ME77 A0A0H3ME77 A0A0H3ME77 A0A0H3ME77 A0A328GBJ6 A0A328GBJ6
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