The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
MAN1, winged-helix domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: MAN1, winged-helix domain

This superfamily entry represents the winged-helix domain located at the C-terminal end of MAN1, an integral protein of the inner nuclear membrane which binds to chromatin associated proteins and plays a role in nuclear organisation. The C-terminal nucleoplasmic region forms a DNA binding winged helix and binds to Smad PMID:16648637. This C-terminal tail is also found in S. cerevisiae and is thought to consist of three conserved helices followed by two downstream strands PMID:15611647. The carboxyl-terminal nucleoplasmic region of MAN1, comprising residues 655-910, exhibits two potential globular domains, an alpha/beta structure which corresponds to a winged-helix domain. The first region of the domain is conserved in all MAN1 analogs. The N-terminal half of the domain is mainly alpha-helical, whereas the C-terminal half is composed of two large beta-strands arranged in a twisted anti-parallel beta-sheet PMID:16648637.

PFAM:PF09402,INTERPRO:IPR018996

GO Diversity

Unique GO annotations
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54 Unique GO terms

EC Diversity

Unique EC annotations
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0 Unique EC terms

Species Diversity

Unique species annotations
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1165 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.
Created with Highcharts 3.0.5Sequence DiversityStructural DiversityAll Superfamilies1.10.10.1180

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 10
Function
Unique EC:
Unique GO: 54
Taxonomy
Unique Species: 1165
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