CATH Superfamily 1.10.10.10
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".
FunFam 8: E2F transcription factor 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 44 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
31 |
F4ILT1 (/IPI)
G5EF11 (/IPI)
O00716 (/IPI)
O09139 (/IPI)
O35261 (/IPI)
O35261 (/IPI)
O75461 (/IPI)
O75461 (/IPI)
O75461 (/IPI)
O75461 (/IPI)
(21 more) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
16 |
O35261 (/IDA)
O35261 (/IDA)
O54917 (/IDA)
P56931 (/IDA)
Q01094 (/IDA)
Q16254 (/IDA)
Q27368 (/IDA)
Q27368 (/IDA)
Q61501 (/IDA)
Q61501 (/IDA)
(6 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
13 |
F4ILT1 (/IDA)
O35261 (/IDA)
O35261 (/IDA)
O54917 (/IDA)
Q01094 (/IDA)
Q27368 (/IDA)
Q27368 (/IDA)
Q8R0K9 (/IDA)
Q9FNY0 (/IDA)
Q9FV70 (/IDA)
(3 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
11 |
O00716 (/ISA)
O75461 (/ISA)
O75461 (/ISA)
O75461 (/ISA)
O75461 (/ISA)
O75461 (/ISA)
Q01094 (/ISA)
Q14209 (/ISA)
Q15329 (/ISA)
Q15329 (/ISA)
(1 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
11 |
O00716 (/ISM)
O75461 (/ISM)
O75461 (/ISM)
O75461 (/ISM)
O75461 (/ISM)
O75461 (/ISM)
Q01094 (/ISM)
Q14209 (/ISM)
Q15329 (/ISM)
Q15329 (/ISM)
(1 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
11 |
O00716 (/NAS)
O75461 (/NAS)
O75461 (/NAS)
O75461 (/NAS)
O75461 (/NAS)
O75461 (/NAS)
Q01094 (/NAS)
Q14209 (/NAS)
Q15329 (/NAS)
Q15329 (/NAS)
(1 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
10 | G5EF11 (/IPI) Q01094 (/IPI) Q14209 (/IPI) Q15329 (/IPI) Q15329 (/IPI) Q16254 (/IPI) Q27368 (/IPI) Q27368 (/IPI) Q61501 (/IPI) Q61501 (/IPI) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
7 | F4ILT1 (/ISS) Q27368 (/ISS) Q27368 (/ISS) Q9FV70 (/ISS) Q9FV70 (/ISS) Q9FV71 (/ISS) Q9FV71 (/ISS) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
7 | O00716 (/IDA) O09139 (/IDA) Q01094 (/IDA) Q14209 (/IDA) Q61501 (/IDA) Q61501 (/IDA) Q62814 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
6 | O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) Q14209 (/TAS) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
6 | O35261 (/ISO) O35261 (/ISO) P56931 (/ISO) Q61501 (/ISO) Q61501 (/ISO) Q61502 (/ISO) |
|
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
5 | O35261 (/ISO) O35261 (/ISO) P56931 (/ISO) Q61501 (/ISO) Q61501 (/ISO) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
5 | O00716 (/TAS) O09139 (/TAS) Q01094 (/TAS) Q62814 (/TAS) Q8R0K9 (/TAS) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
5 | O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
5 | P56931 (/ISO) Q61501 (/ISO) Q61501 (/ISO) Q61502 (/ISO) Q8R0K9 (/ISO) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | O09139 (/ISS) Q61501 (/ISS) Q61501 (/ISS) |
|
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
3 | O00716 (/IDA) Q01094 (/IDA) Q14209 (/IDA) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | O00716 (/IC) Q14209 (/IC) Q16254 (/IC) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | Q27368 (/IDA) Q27368 (/IDA) Q8R0K9 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
3 | Q61501 (/ISO) Q61501 (/ISO) Q8R0K9 (/ISO) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
3 | Q61501 (/ISO) Q61501 (/ISO) Q8R0K9 (/ISO) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
3 | Q14209 (/NAS) Q15329 (/NAS) Q15329 (/NAS) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
2 | Q16254 (/IDA) Q8R0K9 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
2 | Q27368 (/IDA) Q27368 (/IDA) |
|
RNA polymerase II regulatory region DNA binding GO:0001012
Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
2 | Q27368 (/IMP) Q27368 (/IMP) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q01094 (/IMP) Q16254 (/IMP) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
2 | Q6DE14 (/IMP) Q6DE14 (/IMP) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
2 | Q9FV70 (/IPI) Q9FV70 (/IPI) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
2 | Q61501 (/IDA) Q61501 (/IDA) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
2 | Q9FV70 (/IPI) Q9FV70 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q9FV70 (/IPI) Q9FV70 (/IPI) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | Q8R0K9 (/ISO) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q01094 (/IMP) |
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | Q01094 (/IC) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | G5EF11 (/IPI) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | O09139 (/IPI) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q16254 (/IPI) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | Q8R0K9 (/ISO) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
1 | Q01094 (/ISS) |
|
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | G5EF11 (/IPI) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
1 | Q16254 (/IDA) |
|
Promoter-specific chromatin binding GO:1990841
Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA.
|
1 | Q8R0K9 (/ISO) |
There are 134 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
8 | O35261 (/IDA) O35261 (/IDA) Q01094 (/IDA) Q61501 (/IDA) Q61501 (/IDA) Q9FNY0 (/IDA) Q9FV71 (/IDA) Q9FV71 (/IDA) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
7 | O75461 (/IDA) O75461 (/IDA) O75461 (/IDA) O75461 (/IDA) O75461 (/IDA) Q27368 (/IDA) Q27368 (/IDA) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
7 | O35261 (/IDA) O35261 (/IDA) P56931 (/IDA) Q01094 (/IDA) Q61501 (/IDA) Q61501 (/IDA) Q61502 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
7 | O00716 (/IDA) Q14209 (/IDA) Q16254 (/IDA) Q27368 (/IDA) Q27368 (/IDA) Q61501 (/IDA) Q61501 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
6 | O35261 (/ISO) O35261 (/ISO) P56931 (/ISO) Q61501 (/ISO) Q61501 (/ISO) Q8R0K9 (/ISO) |
|
Negative regulation of G0 to G1 transition GO:0070317
A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
|
6 | O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) Q01094 (/TAS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) O75461 (/TAS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
5 | O09139 (/ISS) Q16254 (/ISS) Q61501 (/ISS) Q61501 (/ISS) Q8R0K9 (/ISS) |
|
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
|
4 | O09139 (/TAS) Q27368 (/TAS) Q27368 (/TAS) Q61502 (/TAS) |
|
DNA endoreduplication GO:0042023
Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.
|
4 | Q27368 (/IMP) Q27368 (/IMP) Q9FV70 (/IMP) Q9FV70 (/IMP) |
|
Negative regulation of fat cell proliferation GO:0070345
Any process that stops or decreases the rate or extent of fat cell proliferation.
|
4 | O35261 (/IMP) O35261 (/IMP) Q61501 (/IMP) Q61501 (/IMP) |
|
DNA damage checkpoint GO:0000077
A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
|
3 | O09139 (/ISS) Q61501 (/ISS) Q61501 (/ISS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | O54917 (/ISO) Q61501 (/ISO) Q61501 (/ISO) |
|
Regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage GO:0010767
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus.
|
3 | Q8R0K9 (/IMP) Q9FV70 (/IMP) Q9FV70 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q61501 (/IGI) Q61501 (/IGI) Q8R0K9 (/IGI) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q01094 (/IMP) Q6DE14 (/IMP) Q6DE14 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q15329 (/TAS) Q15329 (/TAS) Q16254 (/TAS) |
|
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
3 | P56931 (/IDA) Q61501 (/IDA) Q61501 (/IDA) |
|
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
3 | Q61502 (/TAS) Q62814 (/TAS) Q8R0K9 (/TAS) |
|
Negative regulation of fat cell proliferation GO:0070345
Any process that stops or decreases the rate or extent of fat cell proliferation.
|
3 | O00716 (/ISS) O09139 (/ISS) Q01094 (/ISS) |
|
Intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
|
3 | P56931 (/IDA) Q61501 (/IDA) Q61501 (/IDA) |
|
Lens fiber cell apoptotic process GO:1990086
Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.
|
3 | P56931 (/IDA) Q61501 (/IDA) Q61501 (/IDA) |
|
DNA damage checkpoint GO:0000077
A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083
Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.
|
2 | O54917 (/IGI) Q8R0K9 (/IGI) |
|
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
|
2 | Q9FV70 (/IMP) Q9FV70 (/IMP) |
|
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
|
2 | Q61501 (/IDA) Q61501 (/IDA) |
|
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
|
2 | O09139 (/ISS) Q01094 (/ISS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q62814 (/TAS) Q8R0K9 (/TAS) |
|
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
|
2 | O00716 (/TAS) Q14209 (/TAS) |
|
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
|
2 | Q01094 (/TAS) Q16254 (/TAS) |
|
Eggshell chorion gene amplification GO:0007307
Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster.
|
2 | Q27368 (/TAS) Q27368 (/TAS) |
|
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
|
2 | Q27368 (/HMP) Q27368 (/HMP) |
|
Imaginal disc development GO:0007444
The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.).
|
2 | Q27368 (/TAS) Q27368 (/TAS) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | O35261 (/IDA) O35261 (/IDA) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
2 | Q9FV71 (/IMP) Q9FV71 (/IMP) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Response to auxin GO:0009733
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
|
2 | Q9FV71 (/IEP) Q9FV71 (/IEP) |
|
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
|
2 | Q61502 (/IMP) Q8R0K9 (/IMP) |
|
Trichome morphogenesis GO:0010090
The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana.
|
2 | Q9FV71 (/IMP) Q9FV71 (/IMP) |
|
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q27368 (/IMP) Q27368 (/IMP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q27368 (/IMP) Q27368 (/IMP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Antimicrobial humoral response GO:0019730
An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
|
2 | Q27368 (/IMP) Q27368 (/IMP) |
|
Glucosinolate metabolic process GO:0019760
The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.
|
2 | Q9FV70 (/IMP) Q9FV70 (/IMP) |
|
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
|
2 | Q61501 (/IMP) Q61501 (/IMP) |
|
Positive regulation of DNA endoreduplication GO:0032877
Any process that activates or increases the frequency, rate or extent of DNA endoreduplication.
|
2 | Q27368 (/IMP) Q27368 (/IMP) |
|
Larval lymph gland hemopoiesis GO:0035167
The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.
|
2 | Q27368 (/IMP) Q27368 (/IMP) |
|
Regulation of hemocyte proliferation GO:0035206
Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.
|
2 | Q27368 (/IMP) Q27368 (/IMP) |
|
DNA endoreduplication GO:0042023
Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.
|
2 | Q27368 (/IGI) Q27368 (/IGI) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Positive regulation of programmed cell death GO:0043068
Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
|
2 | Q9FV70 (/IMP) Q9FV70 (/IMP) |
|
Anoikis GO:0043276
Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
|
2 | Q61501 (/IDA) Q61501 (/IDA) |
|
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Motile cilium assembly GO:0044458
The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
|
2 | Q6DE14 (/IMP) Q6DE14 (/IMP) |
|
Motile cilium assembly GO:0044458
The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
|
2 | Q16254 (/ISS) Q8R0K9 (/ISS) |
|
Nurse cell apoptotic process GO:0045476
Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process.
|
2 | Q27368 (/TAS) Q27368 (/TAS) |
|
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
|
2 | Q61501 (/IDA) Q61501 (/IDA) |
|
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
|
2 | O09139 (/ISS) Q01094 (/ISS) |
|
Positive regulation of nurse cell apoptotic process GO:0045850
Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process.
|
2 | Q27368 (/IMP) Q27368 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q27368 (/TAS) Q27368 (/TAS) |
|
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
MRNA stabilization GO:0048255
Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
|
2 | Q9FV70 (/IMP) Q9FV70 (/IMP) |
|
Regulation of cell division GO:0051302
Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.
|
2 | Q9FV71 (/IMP) Q9FV71 (/IMP) |
|
Positive regulation of meiotic cell cycle GO:0051446
Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.
|
2 | Q9FV71 (/IMP) Q9FV71 (/IMP) |
|
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
2 | Q27368 (/IMP) Q27368 (/IMP) |
|
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
|
2 | Q27368 (/NAS) Q27368 (/NAS) |
|
Negative regulation of cell division GO:0051782
Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.
|
2 | Q9FV70 (/IMP) Q9FV70 (/IMP) |
|
Positive regulation of glial cell proliferation GO:0060252
Any process that activates or increases the rate or extent of glial cell proliferation.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Cellular response to xenobiotic stimulus GO:0071466
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.
|
2 | Q61501 (/IDA) Q61501 (/IDA) |
|
Negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930
Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Centriole assembly GO:0098534
A cellular process that results in the assembly of one or more centrioles.
|
2 | Q6DE14 (/IMP) Q6DE14 (/IMP) |
|
Centriole assembly GO:0098534
A cellular process that results in the assembly of one or more centrioles.
|
2 | Q16254 (/ISS) Q8R0K9 (/ISS) |
|
Regulation of execution phase of apoptosis GO:1900117
Any process that modulates the frequency, rate or extent of execution phase of apoptosis.
|
2 | Q27368 (/IMP) Q27368 (/IMP) |
|
Multi-ciliated epithelial cell differentiation GO:1903251
The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.
|
2 | Q6DE14 (/IMP) Q6DE14 (/IMP) |
|
Multi-ciliated epithelial cell differentiation GO:1903251
The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.
|
2 | Q16254 (/ISS) Q8R0K9 (/ISS) |
|
Positive regulation of TORC1 signaling GO:1904263
Any process that activates or increases the frequency, rate or extent of TORC1 signaling.
|
2 | Q27368 (/IGI) Q27368 (/IGI) |
|
Positive regulation of TORC1 signaling GO:1904263
Any process that activates or increases the frequency, rate or extent of TORC1 signaling.
|
2 | Q27368 (/IMP) Q27368 (/IMP) |
|
Positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461
Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.
|
2 | O35261 (/ISO) O35261 (/ISO) |
|
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
Regulation of G1/S transition of mitotic cell cycle GO:2000045
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
2 | Q61501 (/ISO) Q61501 (/ISO) |
|
DNA damage checkpoint GO:0000077
A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
|
1 | Q01094 (/IMP) |
|
Regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083
Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.
|
1 | Q8R0K9 (/IDA) |
|
Regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083
Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.
|
1 | Q01094 (/TAS) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q01094 (/IMP) |
|
Epithelial cell development GO:0002064
The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
|
1 | Q8R0K9 (/IMP) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | O09139 (/ISS) |
|
Cell volume homeostasis GO:0006884
Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.
|
1 | Q8R0K9 (/IMP) |
|
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
|
1 | H9GY24 (/IGI) |
|
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
|
1 | H9GY24 (/IMP) |
|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | O09139 (/IEP) |
|
Blood circulation GO:0008015
The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
|
1 | Q8R0K9 (/IMP) |
|
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
|
1 | Q8R0K9 (/IMP) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
1 | Q01094 (/IMP) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
1 | O09139 (/ISS) |
|
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
|
1 | Q8R0K9 (/IDA) |
|
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
|
1 | Q8R0K9 (/IDA) |
|
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
|
1 | Q8R0K9 (/IMP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q01094 (/IDA) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | G5EF11 (/IMP) |
|
Regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage GO:0010767
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus.
|
1 | Q8R0K9 (/IDA) |
|
Negative regulation of vulval development GO:0040027
Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
|
1 | G5EF11 (/IGI) |
|
Negative regulation of vulval development GO:0040027
Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.
|
1 | G5EF11 (/IMP) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
1 | Q8R0K9 (/IDA) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q01094 (/IDA) |
|
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
1 | Q01094 (/IDA) |
|
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
|
1 | O09139 (/ISS) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q01094 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q01094 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | O09139 (/ISS) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q01094 (/IMP) |
|
Negative regulation of Ras protein signal transduction GO:0046580
Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
|
1 | G5EF11 (/IMP) |
|
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
|
1 | Q01094 (/IMP) |
|
MRNA stabilization GO:0048255
Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules.
|
1 | Q01094 (/IDA) |
|
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
|
1 | H9GY24 (/IGI) |
|
Cell maturation GO:0048469
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.
|
1 | H9GY24 (/IMP) |
|
Embryonic digestive tract morphogenesis GO:0048557
The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | G5EF11 (/IGI) |
|
Positive regulation of meiotic cell cycle GO:0051446
Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.
|
1 | Q9FNY0 (/IDA) |
|
Positive regulation of glial cell proliferation GO:0060252
Any process that activates or increases the rate or extent of glial cell proliferation.
|
1 | O09139 (/IMP) |
|
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
|
1 | Q8R0K9 (/IMP) |
|
Cellular response to fatty acid GO:0071398
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
|
1 | O09139 (/IEP) |
|
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | O09139 (/IEP) |
|
Anatomical structure maturation GO:0071695
A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state.
|
1 | H9GY24 (/IGI) |
|
Anatomical structure maturation GO:0071695
A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state.
|
1 | H9GY24 (/IMP) |
|
Negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930
Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle.
|
1 | Q01094 (/IMP) |
|
Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740
Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway.
|
1 | Q01094 (/TAS) |
|
Negative regulation of sprouting angiogenesis GO:1903671
Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis.
|
1 | Q14209 (/IGI) |
|
Negative regulation of sprouting angiogenesis GO:1903671
Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis.
|
1 | P56931 (/ISO) |
|
Positive regulation of vascular associated smooth muscle cell apoptotic process GO:1905461
Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.
|
1 | O00716 (/IMP) |
|
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
|
1 | O09139 (/IDA) |
|
Regulation of G1/S transition of mitotic cell cycle GO:2000045
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
1 | Q01094 (/IMP) |
There are 31 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
21 |
O09139 (/IDA)
O75461 (/IDA)
O75461 (/IDA)
O75461 (/IDA)
O75461 (/IDA)
O75461 (/IDA)
P56931 (/IDA)
Q01094 (/IDA)
Q15329 (/IDA)
Q15329 (/IDA)
(11 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
17 |
O00716 (/TAS)
O75461 (/TAS)
O75461 (/TAS)
O75461 (/TAS)
O75461 (/TAS)
O75461 (/TAS)
Q01094 (/TAS)
Q14209 (/TAS)
Q15329 (/TAS)
Q15329 (/TAS)
(7 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
16 |
A0A0S2Z3K8 (/IDA)
A0A0S2Z3K8 (/IDA)
A0A0S2Z3K8 (/IDA)
A0A0S2Z3K8 (/IDA)
A0A0S2Z3K8 (/IDA)
O75461 (/IDA)
O75461 (/IDA)
O75461 (/IDA)
O75461 (/IDA)
O75461 (/IDA)
(6 more) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
7 | O00716 (/IDA) O75461 (/IDA) O75461 (/IDA) O75461 (/IDA) O75461 (/IDA) O75461 (/IDA) Q14209 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | O09139 (/IDA) Q61501 (/IDA) Q61501 (/IDA) Q61502 (/IDA) Q9FV71 (/IDA) Q9FV71 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
5 | Q01094 (/IDA) Q16254 (/IDA) Q61501 (/IDA) Q61501 (/IDA) Q8R0K9 (/IDA) |
|
MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
|
5 | O75461 (/IDA) O75461 (/IDA) O75461 (/IDA) O75461 (/IDA) O75461 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | O54917 (/ISO) Q61501 (/ISO) Q61501 (/ISO) Q61502 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
4 | O54917 (/ISO) Q61501 (/ISO) Q61501 (/ISO) Q8R0K9 (/ISO) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
4 | Q15329 (/IDA) Q15329 (/IDA) Q9FV70 (/IDA) Q9FV70 (/IDA) |
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RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
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4 | O35261 (/ISO) O35261 (/ISO) O54917 (/ISO) P56931 (/ISO) |
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Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
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3 | Q61501 (/ISO) Q61501 (/ISO) Q8R0K9 (/ISO) |
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Rb-E2F complex GO:0035189
A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression.
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3 | Q01094 (/IDA) Q27368 (/IDA) Q27368 (/IDA) |
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Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
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2 | Q15329 (/IDA) Q15329 (/IDA) |
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Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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2 | G5EF11 (/TAS) Q8R0K9 (/TAS) |
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Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
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2 | Q61501 (/IDA) Q61501 (/IDA) |
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Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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2 | Q61501 (/ISO) Q61501 (/ISO) |
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Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
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2 | Q61501 (/ISO) Q61501 (/ISO) |
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Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
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2 | Q61501 (/ISO) Q61501 (/ISO) |
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Rb-E2F complex GO:0035189
A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression.
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2 | Q61501 (/ISO) Q61501 (/ISO) |
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MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
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2 | O54917 (/ISS) Q08DY6 (/ISS) |
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Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
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1 | Q61502 (/ISO) |
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Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
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1 | Q61502 (/TAS) |
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DNA replication factor A complex GO:0005662
A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa.
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1 | O54917 (/IC) |
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Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
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1 | Q61502 (/ISO) |
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Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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1 | Q8R0K9 (/TAS) |
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Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
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1 | Q01094 (/IDA) |
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Sarcoplasm GO:0016528
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
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1 | Q62814 (/IDA) |
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Sarcoplasm GO:0016528
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
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1 | Q61502 (/ISO) |
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Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
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1 | Q01094 (/IDA) |
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MLL1 complex GO:0071339
A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
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1 | O54917 (/ISO) |
